Potential of peptides as inhibitors and mimotopes: Selection of carbohydrate-mimetic peptides from phage display libraries

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Glycoconjugates play various roles in biological processes. In particular, oligosaccharides on the surface of animal cells are involved in virus infection and cell-cell communication. Inhibitors of carbohydrate-protein interactions are potential antiviral drugs. Several anti-influenza drugs such as oseltamivir and zanamivir are derivatives of sialic acid, which inhibits neuraminidase. However, it is very difficult to prepare a diverse range of sugar derivatives by chemical synthesis or by the isolation of natural products. In addition, the pathogenic capsular polysaccharides of bacteria are carbohydrate antigens, for which a safe and efficacious method of vaccination is required. Phage-display technology has been improved to enable the identification of peptides that bind to carbohydrate-binding proteins, such as lectins and antibodies, from a large repertoire of peptide sequences. These peptides are known as carbohydrate-mimetic peptides (CMPs) because they mimic carbohydrate structures. Compared to carbohydrate derivatives, it is easy to prepare mono- and multivalent peptides and then to modify them to create various derivatives. Such mimetic peptides are available as peptide inhibitors of carbohydrate-protein interactions and peptide mimotopes that are conjugated with adjuvant for vaccination.

Original languageEnglish
Article number740982
JournalJournal of Nucleic Acids
Volume2012
DOIs
Publication statusPublished - 2012 Nov 19

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Potential of peptides as inhibitors and mimotopes: Selection of carbohydrate-mimetic peptides from phage display libraries'. Together they form a unique fingerprint.

  • Cite this