Potential role of angiotensin receptor antagonists in renal protection

K. Hayashi, H. Matsuda, M. Honda, T. Saruta

Research output: Contribution to journalArticle

Abstract

Recent clinical studies have established an important role of angiotensin converting enzyme inhibitors (ACE-I) as a tool for renal protection. Although angiotensin receptor antagonists (AII-A) share the common property with ACE-I with regard to blockade of angiotensin activity via angiotensin type 1 receptors (AT1), AII-A is also reported to stimulate AT2 that plausibly activates nitric oxide production within renal medulla and augments synthesis of vasodilatory P450-metabolites in renal afferent arterioles. In contrast, AII-A is reported to have no effect on bradykinin activity. Results obtained in experimental animals indicate that AII-A effectively prevents the progression of renal injury. Several clinical studies are in progress, and the preliminary results suggest that AII-A has potent renal protective action in a variety of renal disorders.

Original languageEnglish
Pages (from-to)1164-1167
Number of pages4
JournalNippon rinsho. Japanese journal of clinical medicine
Volume57
Issue number5
Publication statusPublished - 1999

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Angiotensin Receptor Antagonists
Kidney
Angiotensin-Converting Enzyme Inhibitors
Angiotensin Type 1 Receptor
Angiotensins
Arterioles
Bradykinin
Nitric Oxide
Wounds and Injuries

Cite this

Potential role of angiotensin receptor antagonists in renal protection. / Hayashi, K.; Matsuda, H.; Honda, M.; Saruta, T.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 57, No. 5, 1999, p. 1164-1167.

Research output: Contribution to journalArticle

Hayashi, K, Matsuda, H, Honda, M & Saruta, T 1999, 'Potential role of angiotensin receptor antagonists in renal protection', Nippon rinsho. Japanese journal of clinical medicine, vol. 57, no. 5, pp. 1164-1167.
Hayashi, K. ; Matsuda, H. ; Honda, M. ; Saruta, T. / Potential role of angiotensin receptor antagonists in renal protection. In: Nippon rinsho. Japanese journal of clinical medicine. 1999 ; Vol. 57, No. 5. pp. 1164-1167.
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