Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: Morphological significance of calponin h1

Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Nobuyoshi Hiraoka, Mari Kasai, Tomoyuki Ichimura, Tamotsu Sudo, Ryuichiro Nishimura, Osamu Ishiko, Tanri Shiozawa, Yae Kanai, Nobuo Yaegashi, Hiroyuki Aburatani, Ikuo Konishi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 is suspected to have a biological role as a tumor-suppressor. We earlier reported that LMP2-null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti-tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that although calponin h1 does not directly influence tumorigenesis, it clearly affects LMP2-induced cellular morphological changes. Modulation of LMP2 may lead to new therapeutic approaches in human uterine LMS.

Original languageEnglish
Pages (from-to)1824-1831
Number of pages8
JournalFEBS Letters
Volume586
Issue number13
DOIs
Publication statusPublished - 2012 Jun 21

Keywords

  • Calponin h1
  • Cell morphology
  • LMP2
  • Uterine leiomyosarcoma

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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