Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity

Toshiro Hirai, Yasuo Yoshioka, Asako Udaka, Eiichiro Uemura, Tomoyuki Ohe, Hisae Aoshima, Jian Qing Gao, Ken Kokubo, Takumi Oshima, Kazuya Nagano, Kazuma Higashisaka, Tadahiko Mashino, Yasuo Tsutsumi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The therapeutic effects of fullerene derivatives on many models of inflammatory disease have been demonstrated. The anti-inflammatory mechanisms of these nanoparticles remain to be elucidated, though their beneficial roles in allergy and autoimmune diseases suggest their suppressive potential in acquired immunity. Here, we evaluated the effects of C60 pyrrolidine tris-acid (C60-P) and polyhydroxylated fullerene (C60(OH)36) on the acquired immune response in vitro and in vivo. In vitro, both C60 derivatives had dose-dependent suppressive effects on T cell receptor-mediated activation of T cells and antibody production by B cells under anti-CD40/IL-4 stimulation, similar to the actions of the antioxidant N-acetylcysteine. In addition, C60-P suppressed ovalbumin-specific antibody production and ovalbumin-specific T cell responses in vivo, although T cell-independent antibodies responses were not affected by C60-P. Together, our data suggest that fullerene derivatives can suppress acquired immune responses that require T cells.

Original languageEnglish
Article number449
JournalNanoscale Research Letters
Volume11
Issue number1
DOIs
Publication statusPublished - 2016 Dec 1

Fingerprint

T-cells
immunity
Fullerenes
fullerenes
Derivatives
Antibodies
Ovalbumin
antibodies
Allergies
Acetylcysteine
T-Cell Antigen Receptor
Interleukin-4
Antioxidants
Anti-Inflammatory Agents
Chemical activation
Cells
antioxidants
Nanoparticles
stimulation
Acids

Keywords

  • Acquired immunity
  • B cell
  • C
  • Fullerene
  • Nanomaterial
  • T cell

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity. / Hirai, Toshiro; Yoshioka, Yasuo; Udaka, Asako; Uemura, Eiichiro; Ohe, Tomoyuki; Aoshima, Hisae; Gao, Jian Qing; Kokubo, Ken; Oshima, Takumi; Nagano, Kazuya; Higashisaka, Kazuma; Mashino, Tadahiko; Tsutsumi, Yasuo.

In: Nanoscale Research Letters, Vol. 11, No. 1, 449, 01.12.2016.

Research output: Contribution to journalArticle

Hirai, T, Yoshioka, Y, Udaka, A, Uemura, E, Ohe, T, Aoshima, H, Gao, JQ, Kokubo, K, Oshima, T, Nagano, K, Higashisaka, K, Mashino, T & Tsutsumi, Y 2016, 'Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity', Nanoscale Research Letters, vol. 11, no. 1, 449. https://doi.org/10.1186/s11671-016-1663-7
Hirai, Toshiro ; Yoshioka, Yasuo ; Udaka, Asako ; Uemura, Eiichiro ; Ohe, Tomoyuki ; Aoshima, Hisae ; Gao, Jian Qing ; Kokubo, Ken ; Oshima, Takumi ; Nagano, Kazuya ; Higashisaka, Kazuma ; Mashino, Tadahiko ; Tsutsumi, Yasuo. / Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity. In: Nanoscale Research Letters. 2016 ; Vol. 11, No. 1.
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