Potential use of biological proteins for liver failure therapy

Kazuaki Taguchi, Keishi Yamasaki, Hakaru Seo, Masaki Otagiri

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Biological proteins have unlimited potential for use as pharmaceutical products due to their various biological activities, which include non-toxicity, biocompatibility, and biodegradability. Recent scientific advances allow for the development of novel innovative protein-based products that draw on the quality of their innate biological activities. Some of them hold promising potential for novel therapeutic agents/devices for addressing hepatic diseases such as hepatitis, fibrosis, and hepatocarcinomas. This review attempts to provide an overview of the development of protein-based products that take advantage of their biological activity for medication, and discusses possibilities for the therapeutic potential of protein-based products produced through different approaches to specifically target the liver (or hepatic cells: hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells, and Kupffer cells) in the treatment of hepatic diseases.

Original languageEnglish
Pages (from-to)255-274
Number of pages20
JournalPharmaceutics
Volume7
Issue number3
DOIs
Publication statusPublished - 2015 Aug 31
Externally publishedYes

Keywords

  • Albumin
  • Drug delivery
  • Erythropoietin
  • Gelatin
  • Hemoglobin
  • Lactoferrin
  • Nanomedicine
  • α-acid glycoprotein

ASJC Scopus subject areas

  • Pharmaceutical Science

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