Potential use of endothelial progenitor cells for regeneration of the vasculature

Kenichi Yamahara, Hiroshi Itoh

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Over the past decade, interest has been generated in the study of endothelial progenitor cells (EPCs). EPCs have been studied for their role in endogenous maintenance and for their therapeutic potential in vascular regenerative medicine. Despite their obvious potential in clinical practice, there still remain many controversies regarding how EPCs actually enhance endothelial repair and neovascularization. In addition, because of the limited expansion ability of EPCs, expansion of sufficient EPC populations for therapeutic angiogenesis remains a major task. On the other hand, embryonic stem (ES) cells have an extended self-renewal activity and can be expanded without limit, thus ES-cell-derived endothelial cells could be feasible as a novel cell source for therapeutic angiogenesis. In this review, we discuss recent experimental and clinical findings of EPCs and human ES-cell-derived endothelial cells for the treatment of ischemic cardiovascular diseases.

Original languageEnglish
Pages (from-to)17-27
Number of pages11
JournalTherapeutic Advances in Cardiovascular Disease
Volume3
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Regeneration
Embryonic Stem Cells
Endothelial Cells
Regenerative Medicine
Cardiology
Endothelial Progenitor Cells
Cardiovascular Diseases
Therapeutics
Maintenance
Population

Keywords

  • Angiogenesis
  • Cardiovascular diseases
  • Endothelium
  • Smooth muscle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Potential use of endothelial progenitor cells for regeneration of the vasculature. / Yamahara, Kenichi; Itoh, Hiroshi.

In: Therapeutic Advances in Cardiovascular Disease, Vol. 3, No. 1, 2009, p. 17-27.

Research output: Contribution to journalArticle

@article{9385dadad2a14993802532cc98ffd0da,
title = "Potential use of endothelial progenitor cells for regeneration of the vasculature",
abstract = "Over the past decade, interest has been generated in the study of endothelial progenitor cells (EPCs). EPCs have been studied for their role in endogenous maintenance and for their therapeutic potential in vascular regenerative medicine. Despite their obvious potential in clinical practice, there still remain many controversies regarding how EPCs actually enhance endothelial repair and neovascularization. In addition, because of the limited expansion ability of EPCs, expansion of sufficient EPC populations for therapeutic angiogenesis remains a major task. On the other hand, embryonic stem (ES) cells have an extended self-renewal activity and can be expanded without limit, thus ES-cell-derived endothelial cells could be feasible as a novel cell source for therapeutic angiogenesis. In this review, we discuss recent experimental and clinical findings of EPCs and human ES-cell-derived endothelial cells for the treatment of ischemic cardiovascular diseases.",
keywords = "Angiogenesis, Cardiovascular diseases, Endothelium, Smooth muscle",
author = "Kenichi Yamahara and Hiroshi Itoh",
year = "2009",
doi = "10.1177/1753944708097728",
language = "English",
volume = "3",
pages = "17--27",
journal = "Therapeutic Advances in Cardiovascular Disease",
issn = "1753-9447",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Potential use of endothelial progenitor cells for regeneration of the vasculature

AU - Yamahara, Kenichi

AU - Itoh, Hiroshi

PY - 2009

Y1 - 2009

N2 - Over the past decade, interest has been generated in the study of endothelial progenitor cells (EPCs). EPCs have been studied for their role in endogenous maintenance and for their therapeutic potential in vascular regenerative medicine. Despite their obvious potential in clinical practice, there still remain many controversies regarding how EPCs actually enhance endothelial repair and neovascularization. In addition, because of the limited expansion ability of EPCs, expansion of sufficient EPC populations for therapeutic angiogenesis remains a major task. On the other hand, embryonic stem (ES) cells have an extended self-renewal activity and can be expanded without limit, thus ES-cell-derived endothelial cells could be feasible as a novel cell source for therapeutic angiogenesis. In this review, we discuss recent experimental and clinical findings of EPCs and human ES-cell-derived endothelial cells for the treatment of ischemic cardiovascular diseases.

AB - Over the past decade, interest has been generated in the study of endothelial progenitor cells (EPCs). EPCs have been studied for their role in endogenous maintenance and for their therapeutic potential in vascular regenerative medicine. Despite their obvious potential in clinical practice, there still remain many controversies regarding how EPCs actually enhance endothelial repair and neovascularization. In addition, because of the limited expansion ability of EPCs, expansion of sufficient EPC populations for therapeutic angiogenesis remains a major task. On the other hand, embryonic stem (ES) cells have an extended self-renewal activity and can be expanded without limit, thus ES-cell-derived endothelial cells could be feasible as a novel cell source for therapeutic angiogenesis. In this review, we discuss recent experimental and clinical findings of EPCs and human ES-cell-derived endothelial cells for the treatment of ischemic cardiovascular diseases.

KW - Angiogenesis

KW - Cardiovascular diseases

KW - Endothelium

KW - Smooth muscle

UR - http://www.scopus.com/inward/record.url?scp=67849087386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67849087386&partnerID=8YFLogxK

U2 - 10.1177/1753944708097728

DO - 10.1177/1753944708097728

M3 - Article

C2 - 19144668

AN - SCOPUS:67849087386

VL - 3

SP - 17

EP - 27

JO - Therapeutic Advances in Cardiovascular Disease

JF - Therapeutic Advances in Cardiovascular Disease

SN - 1753-9447

IS - 1

ER -