Abstract
Over the past decade, interest has been generated in the study of endothelial progenitor cells (EPCs). EPCs have been studied for their role in endogenous maintenance and for their therapeutic potential in vascular regenerative medicine. Despite their obvious potential in clinical practice, there still remain many controversies regarding how EPCs actually enhance endothelial repair and neovascularization. In addition, because of the limited expansion ability of EPCs, expansion of sufficient EPC populations for therapeutic angiogenesis remains a major task. On the other hand, embryonic stem (ES) cells have an extended self-renewal activity and can be expanded without limit, thus ES-cell-derived endothelial cells could be feasible as a novel cell source for therapeutic angiogenesis. In this review, we discuss recent experimental and clinical findings of EPCs and human ES-cell-derived endothelial cells for the treatment of ischemic cardiovascular diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 17-27 |
| Number of pages | 11 |
| Journal | Therapeutic Advances in Cardiovascular Disease |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Angiogenesis
- Cardiovascular diseases
- Endothelium
- Smooth muscle
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pharmacology (medical)
Cite this
Potential use of endothelial progenitor cells for regeneration of the vasculature. / Yamahara, Kenichi; Itoh, Hiroshi.
In: Therapeutic Advances in Cardiovascular Disease, Vol. 3, No. 1, 2009, p. 17-27.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Potential use of endothelial progenitor cells for regeneration of the vasculature
AU - Yamahara, Kenichi
AU - Itoh, Hiroshi
PY - 2009
Y1 - 2009
N2 - Over the past decade, interest has been generated in the study of endothelial progenitor cells (EPCs). EPCs have been studied for their role in endogenous maintenance and for their therapeutic potential in vascular regenerative medicine. Despite their obvious potential in clinical practice, there still remain many controversies regarding how EPCs actually enhance endothelial repair and neovascularization. In addition, because of the limited expansion ability of EPCs, expansion of sufficient EPC populations for therapeutic angiogenesis remains a major task. On the other hand, embryonic stem (ES) cells have an extended self-renewal activity and can be expanded without limit, thus ES-cell-derived endothelial cells could be feasible as a novel cell source for therapeutic angiogenesis. In this review, we discuss recent experimental and clinical findings of EPCs and human ES-cell-derived endothelial cells for the treatment of ischemic cardiovascular diseases.
AB - Over the past decade, interest has been generated in the study of endothelial progenitor cells (EPCs). EPCs have been studied for their role in endogenous maintenance and for their therapeutic potential in vascular regenerative medicine. Despite their obvious potential in clinical practice, there still remain many controversies regarding how EPCs actually enhance endothelial repair and neovascularization. In addition, because of the limited expansion ability of EPCs, expansion of sufficient EPC populations for therapeutic angiogenesis remains a major task. On the other hand, embryonic stem (ES) cells have an extended self-renewal activity and can be expanded without limit, thus ES-cell-derived endothelial cells could be feasible as a novel cell source for therapeutic angiogenesis. In this review, we discuss recent experimental and clinical findings of EPCs and human ES-cell-derived endothelial cells for the treatment of ischemic cardiovascular diseases.
KW - Angiogenesis
KW - Cardiovascular diseases
KW - Endothelium
KW - Smooth muscle
UR - http://www.scopus.com/inward/record.url?scp=67849087386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67849087386&partnerID=8YFLogxK
U2 - 10.1177/1753944708097728
DO - 10.1177/1753944708097728
M3 - Article
C2 - 19144668
AN - SCOPUS:67849087386
VL - 3
SP - 17
EP - 27
JO - Therapeutic Advances in Cardiovascular Disease
JF - Therapeutic Advances in Cardiovascular Disease
SN - 1753-9447
IS - 1
ER -