Practical and efficient enantioselective borohydride reduction of aromatic ketones catalyzed by optically active cobalt(II) complexes using pre-modified borohydride

Kiyoaki D. Sugi, Takushi Nagata, Tohru Yamada, Teruaki Mukaiyama

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A catalytic enantioselective borohydride reduction of aromatic ketones in presence of 0.1-1 mol% of optically active aldiminato cobalt(II) complex catalysts at 0 °C was successfully achieved using precisely pre-modified borohydride with one equivalent each of tetrahydrofurfuryl alcohol, ethanol and NaBH4. The corresponding secondary alcohols were produced in less than 45 min with high enantiomeric excesses (up to 98% ee). The above method was successfully applied to kinetic and dynamic kinetic resolutions of aromatic ketones.

Original languageEnglish
Pages (from-to)1081-1082
Number of pages2
JournalChemistry Letters
Issue number12
Publication statusPublished - 1996
Externally publishedYes

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Borohydrides
Cobalt
Ketones
Kinetics
Ethanol
Alcohols
Catalysts
tetrahydrofurfuryl alcohol

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Practical and efficient enantioselective borohydride reduction of aromatic ketones catalyzed by optically active cobalt(II) complexes using pre-modified borohydride. / Sugi, Kiyoaki D.; Nagata, Takushi; Yamada, Tohru; Mukaiyama, Teruaki.

In: Chemistry Letters, No. 12, 1996, p. 1081-1082.

Research output: Contribution to journalArticle

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