Practical and efficient enantioselective borohydride reduction of aromatic ketones catalyzed by optically active cobalt(II) complexes using pre-modified borohydride

Kiyoaki D. Sugi, Takushi Nagata, Tohru Yamada, Teruaki Mukaiyama

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A catalytic enantioselective borohydride reduction of aromatic ketones in presence of 0.1-1 mol% of optically active aldiminato cobalt(II) complex catalysts at 0 °C was successfully achieved using precisely pre-modified borohydride with one equivalent each of tetrahydrofurfuryl alcohol, ethanol and NaBH4. The corresponding secondary alcohols were produced in less than 45 min with high enantiomeric excesses (up to 98% ee). The above method was successfully applied to kinetic and dynamic kinetic resolutions of aromatic ketones.

Original languageEnglish
Pages (from-to)1081-1082
Number of pages2
JournalChemistry Letters
Issue number12
Publication statusPublished - 1996 Jan 1
Externally publishedYes


ASJC Scopus subject areas

  • Chemistry(all)

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