Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor

Yosuke Uchinashi; Katsunori Tanaka; Yoshiyuki Manabe; Yukari Fujimoto; Koichi Fukase

doi:10.1080/07328303.2014.880116

Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor

Yosuke Uchinashi, Katsunori Tanaka, Yoshiyuki Manabe, Yukari Fujimoto, Koichi Fukase

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. © 2014

Original language	English
Pages (from-to)	55-67
Number of pages	13
Journal	Journal of Carbohydrate Chemistry
Volume	33
Issue number	2
DOIs	https://doi.org/10.1080/07328303.2014.880116
Publication status	Published - 2014 Feb 12
Externally published	Yes

Keywords

Comet X-01
Micromixer
Sialic acid
α-Sialylation

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

Access to Document

10.1080/07328303.2014.880116

Fingerprint Dive into the research topics of 'Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor'. Together they form a unique fingerprint.

Cite this

@article{509dc5483b2b4dc7b38b7459264f6316,

title = "Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor",

abstract = "Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. {\textcopyright} 2014",

keywords = "Comet X-01, Micromixer, Sialic acid, α-Sialylation",

author = "Yosuke Uchinashi and Katsunori Tanaka and Yoshiyuki Manabe and Yukari Fujimoto and Koichi Fukase",

year = "2014",

month = feb,

day = "12",

doi = "10.1080/07328303.2014.880116",

language = "English",

volume = "33",

pages = "55--67",

journal = "Journal of Carbohydrate Chemistry",

issn = "0732-8303",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

TY - JOUR

T1 - Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor

AU - Uchinashi, Yosuke

AU - Tanaka, Katsunori

AU - Manabe, Yoshiyuki

AU - Fujimoto, Yukari

AU - Fukase, Koichi

PY - 2014/2/12

Y1 - 2014/2/12

N2 - Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. © 2014

AB - Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. © 2014

KW - Comet X-01

KW - Micromixer

KW - Sialic acid

KW - α-Sialylation

UR - http://www.scopus.com/inward/record.url?scp=84896334777&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896334777&partnerID=8YFLogxK

U2 - 10.1080/07328303.2014.880116

DO - 10.1080/07328303.2014.880116

M3 - Article

AN - SCOPUS:84896334777

VL - 33

SP - 55

EP - 67

JO - Journal of Carbohydrate Chemistry

JF - Journal of Carbohydrate Chemistry

SN - 0732-8303

IS - 2

ER -