Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor

Yosuke Uchinashi; Katsunori Tanaka; Yoshiyuki Manabe; Yukari Fujimoto; Koichi Fukase

doi:10.1080/07328303.2014.880116

Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor

Yosuke Uchinashi, Katsunori Tanaka, Yoshiyuki Manabe, Yukari Fujimoto, Koichi Fukase

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. © 2014

Original language	English
Pages (from-to)	55-67
Number of pages	13
Journal	Journal of Carbohydrate Chemistry
Volume	33
Issue number	2
DOIs	https://doi.org/10.1080/07328303.2014.880116
Publication status	Published - 2014 Feb 12
Externally published	Yes

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Keywords

Comet X-01
Micromixer
Sialic acid
α-Sialylation

ASJC Scopus subject areas

Organic Chemistry
Biochemistry

Cite this

Uchinashi, Y., Tanaka, K., Manabe, Y., Fujimoto, Y., & Fukase, K. (2014). Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor. Journal of Carbohydrate Chemistry, 33(2), 55-67. https://doi.org/10.1080/07328303.2014.880116

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10.1080/07328303.2014.880116