Abstract
Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. © 2014
| Original language | English |
|---|---|
| Pages (from-to) | 55-67 |
| Number of pages | 13 |
| Journal | Journal of Carbohydrate Chemistry |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Feb 12 |
| Externally published | Yes |
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Keywords
- Comet X-01
- Micromixer
- Sialic acid
- α-Sialylation
ASJC Scopus subject areas
- Organic Chemistry
- Biochemistry
Cite this
Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor. / Uchinashi, Yosuke; Tanaka, Katsunori; Manabe, Yoshiyuki; Fujimoto, Yukari; Fukase, Koichi.
In: Journal of Carbohydrate Chemistry, Vol. 33, No. 2, 12.02.2014, p. 55-67.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor
AU - Uchinashi, Yosuke
AU - Tanaka, Katsunori
AU - Manabe, Yoshiyuki
AU - Fujimoto, Yukari
AU - Fukase, Koichi
PY - 2014/2/12
Y1 - 2014/2/12
N2 - Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. © 2014
AB - Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. © 2014
KW - Comet X-01
KW - Micromixer
KW - Sialic acid
KW - α-Sialylation
UR - http://www.scopus.com/inward/record.url?scp=84896334777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896334777&partnerID=8YFLogxK
U2 - 10.1080/07328303.2014.880116
DO - 10.1080/07328303.2014.880116
M3 - Article
AN - SCOPUS:84896334777
VL - 33
SP - 55
EP - 67
JO - Journal of Carbohydrate Chemistry
JF - Journal of Carbohydrate Chemistry
SN - 0732-8303
IS - 2
ER -