Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor

Yosuke Uchinashi, Katsunori Tanaka, Yoshiyuki Manabe, Yukari Fujimoto, Koichi Fukase

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Efficient α-sialylation with a C5 azide sialyl donor was investigated under microfluidic conditions using a microreactor composed of a Comet X-01 micromixer and a tube reactor. Precise temperature control realized excellent α-selectivity, and Siaα(2,6)Gal, Siaα(2,3)Gal, and Siaα(2,9)Sia disaccharides were obtained in moderate to good yields. © 2014

Original languageEnglish
Pages (from-to)55-67
Number of pages13
JournalJournal of Carbohydrate Chemistry
Volume33
Issue number2
DOIs
Publication statusPublished - 2014 Feb 12
Externally publishedYes

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Keywords

  • Comet X-01
  • Micromixer
  • Sialic acid
  • α-Sialylation

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry

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