Practical deracemization of NM-3, a synthetic angiogenesis inhibitor

Naoki Kanoh, Ayumi Tomatsu, Tomoyuki Nishikawa, Mitsuaki Ide, Toshio Tsuchida, Kunio Isshiki, Masaya Nakata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The practical deracemization of the angiogenesis inhibitor NM-3 is described. The transformation features the diastereoselective addition of optically active pantolactone to a ketene intermediate and hydrolysis of the pantolactone ester.

Original languageEnglish
Pages (from-to)1251-1253
Number of pages3
JournalTetrahedron Asymmetry
Volume14
Issue number10
DOIs
Publication statusPublished - 2003 May 16

Fingerprint

angiogenesis
Angiogenesis Inhibitors
inhibitors
hydrolysis
esters
Hydrolysis
Esters
pantolactone
ketene

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Kanoh, N., Tomatsu, A., Nishikawa, T., Ide, M., Tsuchida, T., Isshiki, K., & Nakata, M. (2003). Practical deracemization of NM-3, a synthetic angiogenesis inhibitor. Tetrahedron Asymmetry, 14(10), 1251-1253. https://doi.org/10.1016/S0957-4166(03)00240-4

Practical deracemization of NM-3, a synthetic angiogenesis inhibitor. / Kanoh, Naoki; Tomatsu, Ayumi; Nishikawa, Tomoyuki; Ide, Mitsuaki; Tsuchida, Toshio; Isshiki, Kunio; Nakata, Masaya.

In: Tetrahedron Asymmetry, Vol. 14, No. 10, 16.05.2003, p. 1251-1253.

Research output: Contribution to journalArticle

Kanoh, N, Tomatsu, A, Nishikawa, T, Ide, M, Tsuchida, T, Isshiki, K & Nakata, M 2003, 'Practical deracemization of NM-3, a synthetic angiogenesis inhibitor', Tetrahedron Asymmetry, vol. 14, no. 10, pp. 1251-1253. https://doi.org/10.1016/S0957-4166(03)00240-4
Kanoh N, Tomatsu A, Nishikawa T, Ide M, Tsuchida T, Isshiki K et al. Practical deracemization of NM-3, a synthetic angiogenesis inhibitor. Tetrahedron Asymmetry. 2003 May 16;14(10):1251-1253. https://doi.org/10.1016/S0957-4166(03)00240-4
Kanoh, Naoki ; Tomatsu, Ayumi ; Nishikawa, Tomoyuki ; Ide, Mitsuaki ; Tsuchida, Toshio ; Isshiki, Kunio ; Nakata, Masaya. / Practical deracemization of NM-3, a synthetic angiogenesis inhibitor. In: Tetrahedron Asymmetry. 2003 ; Vol. 14, No. 10. pp. 1251-1253.
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