Practical deracemization of NM-3, a synthetic angiogenesis inhibitor

Naoki Kanoh, Ayumi Tomatsu, Tomoyuki Nishikawa, Mitsuaki Ide, Toshio Tsuchida, Kunio Isshiki, Masaya Nakata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The practical deracemization of the angiogenesis inhibitor NM-3 is described. The transformation features the diastereoselective addition of optically active pantolactone to a ketene intermediate and hydrolysis of the pantolactone ester.

Original languageEnglish
Pages (from-to)1251-1253
Number of pages3
JournalTetrahedron Asymmetry
Volume14
Issue number10
DOIs
Publication statusPublished - 2003 May 16

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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  • Cite this

    Kanoh, N., Tomatsu, A., Nishikawa, T., Ide, M., Tsuchida, T., Isshiki, K., & Nakata, M. (2003). Practical deracemization of NM-3, a synthetic angiogenesis inhibitor. Tetrahedron Asymmetry, 14(10), 1251-1253. https://doi.org/10.1016/S0957-4166(03)00240-4