Prediagnosis plasma adiponectin in relation to colorectal cancer risk according to KRAS mutation status

Kentaro Inamura, Mingyang Song, Seungyoun Jung, Reiko Nishihara, Mai Yamauchi, Paul Lochhead, Zhi Rong Qian, Sun A. Kim, Kosuke Mima, Yasutaka Sukawa, Atsuhiro Masuda, Yu Imamura, Xuehong Zhang, Michael N. Pollak, Christos S. Mantzoros, Curtis C. Harris, Edward Giovannucci, Charles S. Fuchs, Eunyoung Cho, Andrew T. ChanKana Wu, Shuji Ogino

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Abstract

Background: Low levels of adiponectin (ADIPOQ; HGNC ID; HGNC:13633), an adipokine, are associated with obesity, adiposity, excess energy balance, and increased risk of colorectal neoplasia. Given the reported association of increased body mass index (BMI) and low-level physical activity with KRAS-mutated colorectal tumor, we hypothesized that low-level plasma adiponectin might be associated with increased risk of KRAS-mutant colorectal carcinoma but not with risk of KRAS wild-type carcinoma. Methods: We conducted molecular pathological epidemiology research using a nested case-control study design (307 incident rectal and colon cancer case patients and 593 matched control individuals) within prospective cohort studies, the Nurses' Health Study (152 case patients and 297 control individuals, with blood collection in 1989-1990) and the Health Professionals Follow-up Study (155 case patients and 296 control individuals, with blood collection in 1993-1995). Multivariable conditional logistic regression models and two-sided likelihood ratio tests were used to assess etiologic heterogeneity of the associations. Results: The association of low-level plasma adiponectin with colorectal cancer risk statistically significantly differed by KRAS mutation status (Pheterogeneity= .004). Low levels of plasma adiponectin were associated with KRAS-mutant colorectal cancer (for the lowest vs highest tertile: multivariable odds ratio [OR] = 2.83, 95% confidence interval [CI] = 1.50 to 5.34, Ptrend = .002) but not with KRAS wild-type cancer (for the lowest vs highest tertile: multivariable OR = 0.83, 95% CI = 0.49

Original languageEnglish
Article numberdjv363
JournalJournal of the National Cancer Institute
Volume108
Issue number4
DOIs
Publication statusPublished - 2016
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Inamura, K., Song, M., Jung, S., Nishihara, R., Yamauchi, M., Lochhead, P., Qian, Z. R., Kim, S. A., Mima, K., Sukawa, Y., Masuda, A., Imamura, Y., Zhang, X., Pollak, M. N., Mantzoros, C. S., Harris, C. C., Giovannucci, E., Fuchs, C. S., Cho, E., ... Ogino, S. (2016). Prediagnosis plasma adiponectin in relation to colorectal cancer risk according to KRAS mutation status. Journal of the National Cancer Institute, 108(4), [djv363]. https://doi.org/10.1093/jnci/djv363