Predicting Individual Remission after Electroconvulsive Therapy Based on Structural Magnetic Resonance Imaging: A Machine Learning Approach

Akihiro Takamiya, Kuo Ching Liang, Shiro Nishikata, Ryosuke Tarumi, Kyosuke Sawada, Shunya Kurokawa, Jinichi Hirano, Bun Yamagata, Masaru Mimura, Taishiro Kishimoto

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To identify important clinical or imaging features predictive of an individual's response to electroconvulsive therapy (ECT) by utilizing a machine learning approach. Methods Twenty-seven depressed patients who received ECT were recruited. Clinical demographics and pretreatment structural magnetic resonance imaging (MRI) data were used as candidate features to build models to predict remission and post-ECT Hamilton Depression Rating Scale scores. Support vector machine and support vector regression with elastic-net regularization were used to build models using (i) only clinical features, (ii) only MRI features, and (iii) both clinical and MRI features. Consistently selected features across all individuals were identified through leave-one-out cross-validation. Results Compared with models that include only clinical variables, the models including MRI data improved the prediction of ECT remission: the prediction accuracy improved from 70% to 93%. Features selected consistently across all individuals included volumes in the gyrus rectus, the right anterior lateral temporal lobe, the cuneus, and the third ventricle, as well as 2 clinical features: psychotic features and family history of mood disorder. Conclusions Pretreatment structural MRI data improved the individual predictive accuracy of ECT remission, and only a small subset of features was important for prediction.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalJournal of ECT
Volume36
Issue number3
DOIs
Publication statusPublished - 2020 Sep 1

Keywords

  • elastic net
  • electroconvulsive therapy (ECT)
  • machine learning
  • magnetic resonance imaging (MRI)
  • prediction

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Predicting Individual Remission after Electroconvulsive Therapy Based on Structural Magnetic Resonance Imaging: A Machine Learning Approach'. Together they form a unique fingerprint.

Cite this