Prediction of axillary lymph node metastasis in primary breast cancer patients using a decision tree-based model

Masahiro Takada, Masahiro Sugimoto, Yasuhiro Naito, Hyeong Gon Moon, Wonshik Han, Dong Young Noh, Masahide Kondo, Katsumasa Kuroi, Hironobu Sasano, Takashi Inamoto, Masaru Tomita, Masakazu Toi

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21 Citations (Scopus)

Abstract

Background: The aim of this study was to develop a new data-mining model to predict axillary lymph node (AxLN) metastasis in primary breast cancer. To achieve this, we used a decision tree-based prediction method-The alternating decision tree (ADTree). Methods: Clinical datasets for primary breast cancer patients who underwent sentinel lymph node biopsy or AxLN dissection without prior treatment were collected from three institutes (institute A, n = 148; institute B, n = 143; institute C, n = 174) and were used for variable selection, model training and external validation, respectively. The models were evaluated using area under the receiver operating characteristics (ROC) curve analysis to discriminate node-positive patients from node-negative patients. Results: The ADTree model selected 15 of 24 clinicopathological variables in the variable selection dataset. The resulting area under the ROC curve values were 0.770 [95% confidence interval (CI), 0.689-0.850] for the model training dataset and 0.772 (95% CI: 0.689-0.856) for the validation dataset, demonstrating high accuracy and generalization ability of the model. The bootstrap value of the validation dataset was 0.768 (95% CI: 0.763-0.774). Conclusions: Our prediction model showed high accuracy for predicting nodal metastasis in patients with breast cancer using commonly recorded clinical variables. Therefore, our model might help oncologists in the decision-making process for primary breast cancer patients before starting treatment.

Original languageEnglish
Article number54
JournalBMC Medical Informatics and Decision Making
Volume12
Issue number1
DOIs
Publication statusPublished - 2012

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Keywords

  • Alternating decision tree
  • Breast cancer
  • Data mining
  • Lymph node metastasis

ASJC Scopus subject areas

  • Health Informatics
  • Health Policy

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