Prediction of extraprostatic extension by prostate specific antigen velocity, endorectal MRI, and biopsy Gleason score in clinically localized prostate cancer

Koshiro Nishimoto, Jun Nakashima, Akinori Hashiguchi, Eiji Kikuchi, Akira Miyajima, Ken Nakagawa, Takashi Ohigashi, Mototsugu Oya, Masaru Murai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: To investigate the clinical value of prostate specific antigen velocity (PSAV) in predicting the extraprostatic extension of clinically localized prostate cancer. Methods: One hundred and three patients who underwent radical prostatectomy for clinically localized prostate cancer were included in the analysis. The correlation between preoperative parameters, including PSA-based parameters, clinical stage, and histological biopsy findings, and the pathological findings were analyzed. Logistic regression analysis was performed to identify a significant set of independent predictors for the local extent of the disease. Results: Sixty-four (60.2%) patients had organ confined prostate cancer and 39 (39.8%) patients had extraprostatic cancer. The biopsy Gleason score, PSA, PSA density, PSA density of the transition zone, and PSAV were significantly higher in the patients with extraprostatic cancer than in those with organ confined cancer. Multivariate logistic regression analysis indicated that the biopsy Gleason score, endorectal magnetic resonance imaging findings, and PSAV were significant predictors of extraprostatic cancer (P < 0.01). Probability curves for extraprostatic cancer were generated using these three preoperative parameters. Conclusions: The combination of PSAV, endorectal magnetic resonance imaging findings, and biopsy Gleason score can provide additional information for selecting appropriate candidates for radical prostatectomy.

Original languageEnglish
Pages (from-to)520-523
Number of pages4
JournalInternational Journal of Urology
Volume15
Issue number6
DOIs
Publication statusPublished - 2008 Jun

Fingerprint

Neoplasm Grading
Prostate-Specific Antigen
Prostatic Neoplasms
Biopsy
Neoplasms
Prostatectomy
Logistic Models
Regression Analysis
Magnetic Resonance Imaging

Keywords

  • Extraprostatic extension
  • Gleason score
  • Prediction
  • PSA velocity
  • Radical prostatectomy

ASJC Scopus subject areas

  • Urology

Cite this

Prediction of extraprostatic extension by prostate specific antigen velocity, endorectal MRI, and biopsy Gleason score in clinically localized prostate cancer. / Nishimoto, Koshiro; Nakashima, Jun; Hashiguchi, Akinori; Kikuchi, Eiji; Miyajima, Akira; Nakagawa, Ken; Ohigashi, Takashi; Oya, Mototsugu; Murai, Masaru.

In: International Journal of Urology, Vol. 15, No. 6, 06.2008, p. 520-523.

Research output: Contribution to journalArticle

Nishimoto, Koshiro ; Nakashima, Jun ; Hashiguchi, Akinori ; Kikuchi, Eiji ; Miyajima, Akira ; Nakagawa, Ken ; Ohigashi, Takashi ; Oya, Mototsugu ; Murai, Masaru. / Prediction of extraprostatic extension by prostate specific antigen velocity, endorectal MRI, and biopsy Gleason score in clinically localized prostate cancer. In: International Journal of Urology. 2008 ; Vol. 15, No. 6. pp. 520-523.
@article{e7af53c7d8dd405eafb6238715b62959,
title = "Prediction of extraprostatic extension by prostate specific antigen velocity, endorectal MRI, and biopsy Gleason score in clinically localized prostate cancer",
abstract = "Objectives: To investigate the clinical value of prostate specific antigen velocity (PSAV) in predicting the extraprostatic extension of clinically localized prostate cancer. Methods: One hundred and three patients who underwent radical prostatectomy for clinically localized prostate cancer were included in the analysis. The correlation between preoperative parameters, including PSA-based parameters, clinical stage, and histological biopsy findings, and the pathological findings were analyzed. Logistic regression analysis was performed to identify a significant set of independent predictors for the local extent of the disease. Results: Sixty-four (60.2{\%}) patients had organ confined prostate cancer and 39 (39.8{\%}) patients had extraprostatic cancer. The biopsy Gleason score, PSA, PSA density, PSA density of the transition zone, and PSAV were significantly higher in the patients with extraprostatic cancer than in those with organ confined cancer. Multivariate logistic regression analysis indicated that the biopsy Gleason score, endorectal magnetic resonance imaging findings, and PSAV were significant predictors of extraprostatic cancer (P < 0.01). Probability curves for extraprostatic cancer were generated using these three preoperative parameters. Conclusions: The combination of PSAV, endorectal magnetic resonance imaging findings, and biopsy Gleason score can provide additional information for selecting appropriate candidates for radical prostatectomy.",
keywords = "Extraprostatic extension, Gleason score, Prediction, PSA velocity, Radical prostatectomy",
author = "Koshiro Nishimoto and Jun Nakashima and Akinori Hashiguchi and Eiji Kikuchi and Akira Miyajima and Ken Nakagawa and Takashi Ohigashi and Mototsugu Oya and Masaru Murai",
year = "2008",
month = "6",
doi = "10.1111/j.1442-2042.2008.02042.x",
language = "English",
volume = "15",
pages = "520--523",
journal = "International Journal of Urology",
issn = "0919-8172",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Prediction of extraprostatic extension by prostate specific antigen velocity, endorectal MRI, and biopsy Gleason score in clinically localized prostate cancer

AU - Nishimoto, Koshiro

AU - Nakashima, Jun

AU - Hashiguchi, Akinori

AU - Kikuchi, Eiji

AU - Miyajima, Akira

AU - Nakagawa, Ken

AU - Ohigashi, Takashi

AU - Oya, Mototsugu

AU - Murai, Masaru

PY - 2008/6

Y1 - 2008/6

N2 - Objectives: To investigate the clinical value of prostate specific antigen velocity (PSAV) in predicting the extraprostatic extension of clinically localized prostate cancer. Methods: One hundred and three patients who underwent radical prostatectomy for clinically localized prostate cancer were included in the analysis. The correlation between preoperative parameters, including PSA-based parameters, clinical stage, and histological biopsy findings, and the pathological findings were analyzed. Logistic regression analysis was performed to identify a significant set of independent predictors for the local extent of the disease. Results: Sixty-four (60.2%) patients had organ confined prostate cancer and 39 (39.8%) patients had extraprostatic cancer. The biopsy Gleason score, PSA, PSA density, PSA density of the transition zone, and PSAV were significantly higher in the patients with extraprostatic cancer than in those with organ confined cancer. Multivariate logistic regression analysis indicated that the biopsy Gleason score, endorectal magnetic resonance imaging findings, and PSAV were significant predictors of extraprostatic cancer (P < 0.01). Probability curves for extraprostatic cancer were generated using these three preoperative parameters. Conclusions: The combination of PSAV, endorectal magnetic resonance imaging findings, and biopsy Gleason score can provide additional information for selecting appropriate candidates for radical prostatectomy.

AB - Objectives: To investigate the clinical value of prostate specific antigen velocity (PSAV) in predicting the extraprostatic extension of clinically localized prostate cancer. Methods: One hundred and three patients who underwent radical prostatectomy for clinically localized prostate cancer were included in the analysis. The correlation between preoperative parameters, including PSA-based parameters, clinical stage, and histological biopsy findings, and the pathological findings were analyzed. Logistic regression analysis was performed to identify a significant set of independent predictors for the local extent of the disease. Results: Sixty-four (60.2%) patients had organ confined prostate cancer and 39 (39.8%) patients had extraprostatic cancer. The biopsy Gleason score, PSA, PSA density, PSA density of the transition zone, and PSAV were significantly higher in the patients with extraprostatic cancer than in those with organ confined cancer. Multivariate logistic regression analysis indicated that the biopsy Gleason score, endorectal magnetic resonance imaging findings, and PSAV were significant predictors of extraprostatic cancer (P < 0.01). Probability curves for extraprostatic cancer were generated using these three preoperative parameters. Conclusions: The combination of PSAV, endorectal magnetic resonance imaging findings, and biopsy Gleason score can provide additional information for selecting appropriate candidates for radical prostatectomy.

KW - Extraprostatic extension

KW - Gleason score

KW - Prediction

KW - PSA velocity

KW - Radical prostatectomy

UR - http://www.scopus.com/inward/record.url?scp=44049085753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44049085753&partnerID=8YFLogxK

U2 - 10.1111/j.1442-2042.2008.02042.x

DO - 10.1111/j.1442-2042.2008.02042.x

M3 - Article

VL - 15

SP - 520

EP - 523

JO - International Journal of Urology

JF - International Journal of Urology

SN - 0919-8172

IS - 6

ER -