Prediction of infectious events by high-sensitivity C-reactive protein level before undergoing chemotherapy for acute myeloid leukaemia

Miki Sato, Shinichi Kako, Kumi Oshima, Ken Sato, Kiriko Terasako, Shun Ichi Kimura, Hideki Nakasone, Shinya Okuda, Rie Yamazaki, Takakazu Higuchi, Junji Nishida, Yoshinobu Kanda

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Abstract

We retrospectively evaluated the serum high-sensitivity C-reactive protein (CRP) level before chemotherapy for the prediction of infectious events during neutropenia in patients with acute myeloid leukaemia. Thirty-eight patients who underwent first induction chemotherapy and 37 patients who underwent first consolidation chemotherapy were analyzed separately. A receiver-operating characteristic (ROC) curve revealed that the serum CRP level just before the first consolidation chemotherapy, but not just before the induction chemotherapy, had a significant predictive value for febrile neutropenia (FN) at a cut-off value of 0.19 mg/dl and documented infection (DI) at a cut-off value of 0.26 mg/dl. The high-sensitivity CRP measurement enabled the detection of slight increases in the serum CRP level, which might reflect a minute inflammation by occult infection, and discriminated high-risk patients for infectious events.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalScandinavian Journal of Infectious Diseases
Volume42
Issue number2
DOIs
Publication statusPublished - 2010 Feb 8
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Sato, M., Kako, S., Oshima, K., Sato, K., Terasako, K., Kimura, S. I., Nakasone, H., Okuda, S., Yamazaki, R., Higuchi, T., Nishida, J., & Kanda, Y. (2010). Prediction of infectious events by high-sensitivity C-reactive protein level before undergoing chemotherapy for acute myeloid leukaemia. Scandinavian Journal of Infectious Diseases, 42(2), 97-101. https://doi.org/10.3109/00365540903331019