Prediction of malignant behavior of pheochromocytomas and paragangliomas using immunohistochemical techniques

Nobue Kumaki, Hiroshi Kajiwara, Kaori Kameyama, Ronald A. DeLellis, Sylvia L. Asa, R. Yoshiyuki Osamura, Hiroshi Takami

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Pheochromocytomas and paragangliomas arise from the adrenal glands and extraadrenal paraganglia, respectively. Malignant behavior of these tumors is uncommon and is, in part, dependent on their sites of origin, such as extraadrenal location. Morphologic criteria for malignancy of pheochromocytoma and paragangliomas have not been clearly defined. In this study, to clarify the histologic features that distinguish the benign from malignant pheochromocytomas and paragangliomas, we examined metastatic and nonmetastatic tumors using immunohistochemical techniques. A total of eight cases, five pheochromocytomas from the adrenal glands (four benign and one malignant tumor) and three paragangliomas with invasion or metastasis, were studied. The markers used in this study were chromogranin A, synaptophysin, NCAM (CD56), SNAP25, neuron-specific enolase, S-100 protein, and MIB-1. Our results suggest that MIB-1 immunostaining is a useful adjunct marker to predict malignant behavior in these tumors.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalEndocrine Pathology
Volume13
Issue number2
DOIs
Publication statusPublished - 2002

Fingerprint

Paraganglioma
Pheochromocytoma
Neoplasms
Adrenal Glands
Neural Cell Adhesion Molecules
Chromogranin A
Synaptophysin
S100 Proteins
Phosphopyruvate Hydratase
Neoplasm Metastasis

Keywords

  • Immunohistochemistry
  • MIB-1
  • Neuroendocrine marker
  • Paraganglioma
  • Pheochromocytoma
  • S-100 protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Prediction of malignant behavior of pheochromocytomas and paragangliomas using immunohistochemical techniques. / Kumaki, Nobue; Kajiwara, Hiroshi; Kameyama, Kaori; DeLellis, Ronald A.; Asa, Sylvia L.; Osamura, R. Yoshiyuki; Takami, Hiroshi.

In: Endocrine Pathology, Vol. 13, No. 2, 2002, p. 149-156.

Research output: Contribution to journalArticle

Kumaki, Nobue ; Kajiwara, Hiroshi ; Kameyama, Kaori ; DeLellis, Ronald A. ; Asa, Sylvia L. ; Osamura, R. Yoshiyuki ; Takami, Hiroshi. / Prediction of malignant behavior of pheochromocytomas and paragangliomas using immunohistochemical techniques. In: Endocrine Pathology. 2002 ; Vol. 13, No. 2. pp. 149-156.
@article{ef98c3f9d5104f24ad40de3883b4c491,
title = "Prediction of malignant behavior of pheochromocytomas and paragangliomas using immunohistochemical techniques",
abstract = "Pheochromocytomas and paragangliomas arise from the adrenal glands and extraadrenal paraganglia, respectively. Malignant behavior of these tumors is uncommon and is, in part, dependent on their sites of origin, such as extraadrenal location. Morphologic criteria for malignancy of pheochromocytoma and paragangliomas have not been clearly defined. In this study, to clarify the histologic features that distinguish the benign from malignant pheochromocytomas and paragangliomas, we examined metastatic and nonmetastatic tumors using immunohistochemical techniques. A total of eight cases, five pheochromocytomas from the adrenal glands (four benign and one malignant tumor) and three paragangliomas with invasion or metastasis, were studied. The markers used in this study were chromogranin A, synaptophysin, NCAM (CD56), SNAP25, neuron-specific enolase, S-100 protein, and MIB-1. Our results suggest that MIB-1 immunostaining is a useful adjunct marker to predict malignant behavior in these tumors.",
keywords = "Immunohistochemistry, MIB-1, Neuroendocrine marker, Paraganglioma, Pheochromocytoma, S-100 protein",
author = "Nobue Kumaki and Hiroshi Kajiwara and Kaori Kameyama and DeLellis, {Ronald A.} and Asa, {Sylvia L.} and Osamura, {R. Yoshiyuki} and Hiroshi Takami",
year = "2002",
doi = "10.1385/EP:13:2:149",
language = "English",
volume = "13",
pages = "149--156",
journal = "Endocrine Pathology",
issn = "1046-3976",
publisher = "Humana Press",
number = "2",

}

TY - JOUR

T1 - Prediction of malignant behavior of pheochromocytomas and paragangliomas using immunohistochemical techniques

AU - Kumaki, Nobue

AU - Kajiwara, Hiroshi

AU - Kameyama, Kaori

AU - DeLellis, Ronald A.

AU - Asa, Sylvia L.

AU - Osamura, R. Yoshiyuki

AU - Takami, Hiroshi

PY - 2002

Y1 - 2002

N2 - Pheochromocytomas and paragangliomas arise from the adrenal glands and extraadrenal paraganglia, respectively. Malignant behavior of these tumors is uncommon and is, in part, dependent on their sites of origin, such as extraadrenal location. Morphologic criteria for malignancy of pheochromocytoma and paragangliomas have not been clearly defined. In this study, to clarify the histologic features that distinguish the benign from malignant pheochromocytomas and paragangliomas, we examined metastatic and nonmetastatic tumors using immunohistochemical techniques. A total of eight cases, five pheochromocytomas from the adrenal glands (four benign and one malignant tumor) and three paragangliomas with invasion or metastasis, were studied. The markers used in this study were chromogranin A, synaptophysin, NCAM (CD56), SNAP25, neuron-specific enolase, S-100 protein, and MIB-1. Our results suggest that MIB-1 immunostaining is a useful adjunct marker to predict malignant behavior in these tumors.

AB - Pheochromocytomas and paragangliomas arise from the adrenal glands and extraadrenal paraganglia, respectively. Malignant behavior of these tumors is uncommon and is, in part, dependent on their sites of origin, such as extraadrenal location. Morphologic criteria for malignancy of pheochromocytoma and paragangliomas have not been clearly defined. In this study, to clarify the histologic features that distinguish the benign from malignant pheochromocytomas and paragangliomas, we examined metastatic and nonmetastatic tumors using immunohistochemical techniques. A total of eight cases, five pheochromocytomas from the adrenal glands (four benign and one malignant tumor) and three paragangliomas with invasion or metastasis, were studied. The markers used in this study were chromogranin A, synaptophysin, NCAM (CD56), SNAP25, neuron-specific enolase, S-100 protein, and MIB-1. Our results suggest that MIB-1 immunostaining is a useful adjunct marker to predict malignant behavior in these tumors.

KW - Immunohistochemistry

KW - MIB-1

KW - Neuroendocrine marker

KW - Paraganglioma

KW - Pheochromocytoma

KW - S-100 protein

UR - http://www.scopus.com/inward/record.url?scp=0036020549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036020549&partnerID=8YFLogxK

U2 - 10.1385/EP:13:2:149

DO - 10.1385/EP:13:2:149

M3 - Article

VL - 13

SP - 149

EP - 156

JO - Endocrine Pathology

JF - Endocrine Pathology

SN - 1046-3976

IS - 2

ER -