Prediction of recovery time from hypoglycemia in patients with insulin overdose

Takako Ohyama, Yoshifumi Saisho, Ayako Muraki, Toshihide Kawai, Hiroshi Itoh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Insulin overdose results in prolonged hypoglycemia. We hypothesized that if a huge amount of insulin is subcutaneously injected, the duration of hypoglycemia depends on the dose of insulin rather than the type of insulin. We conducted a literature review of insulin overdose and 33 cases were included in this study. We assessed the correlation between recovery time from hypoglycemia and insulin dose. As a result, there was a significant correlation between recovery time from hypoglycemia and insulin dose (r = 0.88, p <0.0001) and this correlation was expressed as y = 0.045x; where y is time (h) and x is insulin dose (U), corresponding to that if 1000 U insulin is injected, hypoglycemia will persist for ~45 h. This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose.

Original languageEnglish
Pages (from-to)607-611
Number of pages5
JournalEndocrine Journal
Volume58
Issue number7
DOIs
Publication statusPublished - 2011

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Hypoglycemia
Insulin
Glucose

Keywords

  • Hypoglycemia
  • Insulin overdose
  • Japanese
  • Treatment

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Prediction of recovery time from hypoglycemia in patients with insulin overdose. / Ohyama, Takako; Saisho, Yoshifumi; Muraki, Ayako; Kawai, Toshihide; Itoh, Hiroshi.

In: Endocrine Journal, Vol. 58, No. 7, 2011, p. 607-611.

Research output: Contribution to journalArticle

Ohyama, Takako ; Saisho, Yoshifumi ; Muraki, Ayako ; Kawai, Toshihide ; Itoh, Hiroshi. / Prediction of recovery time from hypoglycemia in patients with insulin overdose. In: Endocrine Journal. 2011 ; Vol. 58, No. 7. pp. 607-611.
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