Abstract
Insulin overdose results in prolonged hypoglycemia. We hypothesized that if a huge amount of insulin is subcutaneously injected, the duration of hypoglycemia depends on the dose of insulin rather than the type of insulin. We conducted a literature review of insulin overdose and 33 cases were included in this study. We assessed the correlation between recovery time from hypoglycemia and insulin dose. As a result, there was a significant correlation between recovery time from hypoglycemia and insulin dose (r = 0.88, p <0.0001) and this correlation was expressed as y = 0.045x; where y is time (h) and x is insulin dose (U), corresponding to that if 1000 U insulin is injected, hypoglycemia will persist for ~45 h. This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose.
| Original language | English |
|---|---|
| Pages (from-to) | 607-611 |
| Number of pages | 5 |
| Journal | Endocrine Journal |
| Volume | 58 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2011 |
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Keywords
- Hypoglycemia
- Insulin overdose
- Japanese
- Treatment
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Prediction of recovery time from hypoglycemia in patients with insulin overdose. / Ohyama, Takako; Saisho, Yoshifumi; Muraki, Ayako; Kawai, Toshihide; Itoh, Hiroshi.
In: Endocrine Journal, Vol. 58, No. 7, 2011, p. 607-611.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prediction of recovery time from hypoglycemia in patients with insulin overdose
AU - Ohyama, Takako
AU - Saisho, Yoshifumi
AU - Muraki, Ayako
AU - Kawai, Toshihide
AU - Itoh, Hiroshi
PY - 2011
Y1 - 2011
N2 - Insulin overdose results in prolonged hypoglycemia. We hypothesized that if a huge amount of insulin is subcutaneously injected, the duration of hypoglycemia depends on the dose of insulin rather than the type of insulin. We conducted a literature review of insulin overdose and 33 cases were included in this study. We assessed the correlation between recovery time from hypoglycemia and insulin dose. As a result, there was a significant correlation between recovery time from hypoglycemia and insulin dose (r = 0.88, p <0.0001) and this correlation was expressed as y = 0.045x; where y is time (h) and x is insulin dose (U), corresponding to that if 1000 U insulin is injected, hypoglycemia will persist for ~45 h. This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose.
AB - Insulin overdose results in prolonged hypoglycemia. We hypothesized that if a huge amount of insulin is subcutaneously injected, the duration of hypoglycemia depends on the dose of insulin rather than the type of insulin. We conducted a literature review of insulin overdose and 33 cases were included in this study. We assessed the correlation between recovery time from hypoglycemia and insulin dose. As a result, there was a significant correlation between recovery time from hypoglycemia and insulin dose (r = 0.88, p <0.0001) and this correlation was expressed as y = 0.045x; where y is time (h) and x is insulin dose (U), corresponding to that if 1000 U insulin is injected, hypoglycemia will persist for ~45 h. This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose.
KW - Hypoglycemia
KW - Insulin overdose
KW - Japanese
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=79961016851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961016851&partnerID=8YFLogxK
U2 - 10.1507/endocrj.K11E-018
DO - 10.1507/endocrj.K11E-018
M3 - Article
C2 - 21519152
AN - SCOPUS:79961016851
VL - 58
SP - 607
EP - 611
JO - Endocrine Journal
JF - Endocrine Journal
SN - 0918-8959
IS - 7
ER -