Prediction of recovery time from hypoglycemia in patients with insulin overdose

Takako Ohyama, Yoshifumi Saisho, Ayako Muraki, Toshihide Kawai, Hiroshi Itoh

Research output: Contribution to journalComment/debate

10 Citations (Scopus)

Abstract

Insulin overdose results in prolonged hypoglycemia. We hypothesized that if a huge amount of insulin is subcutaneously injected, the duration of hypoglycemia depends on the dose of insulin rather than the type of insulin. We conducted a literature review of insulin overdose and 33 cases were included in this study. We assessed the correlation between recovery time from hypoglycemia and insulin dose. As a result, there was a significant correlation between recovery time from hypoglycemia and insulin dose (r = 0.88, p <0.0001) and this correlation was expressed as y = 0.045x; where y is time (h) and x is insulin dose (U), corresponding to that if 1000 U insulin is injected, hypoglycemia will persist for ~45 h. This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose.

Original languageEnglish
Pages (from-to)607-611
Number of pages5
JournalEndocrine journal
Volume58
Issue number7
DOIs
Publication statusPublished - 2011 Aug 5

Keywords

  • Hypoglycemia
  • Insulin overdose
  • Japanese
  • Treatment

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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