Abstract
Insulin overdose results in prolonged hypoglycemia. We hypothesized that if a huge amount of insulin is subcutaneously injected, the duration of hypoglycemia depends on the dose of insulin rather than the type of insulin. We conducted a literature review of insulin overdose and 33 cases were included in this study. We assessed the correlation between recovery time from hypoglycemia and insulin dose. As a result, there was a significant correlation between recovery time from hypoglycemia and insulin dose (r = 0.88, p <0.0001) and this correlation was expressed as y = 0.045x; where y is time (h) and x is insulin dose (U), corresponding to that if 1000 U insulin is injected, hypoglycemia will persist for ~45 h. This equation may be useful to predict the duration of glucose supplementation for treatment of insulin overdose.
Original language | English |
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Pages (from-to) | 607-611 |
Number of pages | 5 |
Journal | Endocrine journal |
Volume | 58 |
Issue number | 7 |
DOIs |
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Publication status | Published - 2011 |
Keywords
- Hypoglycemia
- Insulin overdose
- Japanese
- Treatment
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology