Prediction of transplant-related complications by C-reactive protein levels before hematopoietic SCT

M. Sato, H. Nakasone, K. Oshima, Y. Ishihara, H. Wada, K. Sakamoto, K. Kawamura, M. Ashizawa, T. MacHishima, K. Terasako, S. Kimura, M. Kikuchi, S. Okuda, A. Tanihara, R. Yamazaki, Y. Tanaka, J. Kanda, S. Kako, J. Nishida, Y. Kanda

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20 Citations (Scopus)

Abstract

Various biomarkers have been investigated with regard to their ability to predict the outcome of allogeneic hematopoietic SCT (HSCT). In this study, we retrospectively reviewed 90 recipients who received HSCT between 2007 and 2011 in our institution, and evaluated the predictive value of the baseline serum C-reactive protein (CRP) levels just before the initiation of conditioning for transplant-related complications after allogeneic HSCT. A receiver-operating characteristic curve revealed that the baseline serum CRP levels had an excellent predictive value for non-relapse mortality (NRM), with an area under the curve of 0.83. The sensitivity and specificity for NRM were 80% and 87%, respectively, with a cutoff of 0.6 mg/dL. With this cutoff value, multivariate analyses revealed that a higher baseline CRP level was an independent risk factor for NRM (HR 6.21, P<0.01), grade III-IV acute GVHD (HR 3.91, P=0.03) and poor overall survival (HR 3.27, P=0.0018). On the other hand, the baseline CRP level did not predict infectious events. These findings suggested that CRP levels before conditioning may be a useful predictive biomarker for poor survival.

Original languageEnglish
Pages (from-to)698-702
Number of pages5
JournalBone Marrow Transplantation
Volume48
Issue number5
DOIs
Publication statusPublished - 2013 May 1
Externally publishedYes

Keywords

  • C-reactive protein
  • GVHD
  • hematopoietic SCT
  • infectious events
  • transplant-related complications

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Sato, M., Nakasone, H., Oshima, K., Ishihara, Y., Wada, H., Sakamoto, K., Kawamura, K., Ashizawa, M., MacHishima, T., Terasako, K., Kimura, S., Kikuchi, M., Okuda, S., Tanihara, A., Yamazaki, R., Tanaka, Y., Kanda, J., Kako, S., Nishida, J., & Kanda, Y. (2013). Prediction of transplant-related complications by C-reactive protein levels before hematopoietic SCT. Bone Marrow Transplantation, 48(5), 698-702. https://doi.org/10.1038/bmt.2012.193