Predictive and modifying factors of bone mineral density decline in patients with COPD

Naofumi Kameyama, Shotaro Chubachi, Mamoru Sasaki, Akihiro Tsutsumi, Hidehiro Irie, Kaori Sakurai, Koichi Sayama, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku, Koichi Fukunaga

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Rationale: Various determinants of osteoporosis have been previously identified. However, only a few longitudinal studies have examined related factors. We aimed to investigate factors predicting and modifying rapid decline of bone mineral density in patients with chronic obstructive pulmonary disease. Methods: We analyzed patients with chronic obstructive pulmonary disease whose bone mineral density were measured at least three times over three years (n = 111). We divided annual per cent changes of bone mineral density in different body parts into tertiles. Rapid decliners (n = 33) were defined as those with the largest decline in at least two parts; all other participants were defined as non-rapid decliners (n = 78). Results: At enrollment, bone mineral density did not differ between the two groups. However, rapid decliners had a significantly greater rate of new vertebral fractures over 3 years compared with non-rapid decliners. On multivariate logistic regression analysis, age, moderate to severe emphysema, no daily exercise habits, and anemia increased the likelihood of rapid decliners. Furthermore, patients who newly started and continued bisphosphonate exhibited higher annual per cent changes of bone mineral density than did those without bisphosphonate use. Conclusions: A rapid decline in bone mineral density correlates to a higher likelihood of vertebral fracture. We clarified the predictors of bone mineral density decline and demonstrated that bisphosphonate use might modify bone mineral density in patients with chronic obstructive pulmonary disease.

Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalRespiratory Medicine
Volume148
DOIs
Publication statusPublished - 2019 Mar 1

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Bone Density
Chronic Obstructive Pulmonary Disease
Diphosphonates
Emphysema
Human Body
Osteoporosis
Habits
Longitudinal Studies
Anemia
Logistic Models
Regression Analysis
Exercise

Keywords

  • Bisphosphonate
  • Comorbidity
  • COPD
  • Osteoporosis
  • Vertebral fracture

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Predictive and modifying factors of bone mineral density decline in patients with COPD. / Kameyama, Naofumi; Chubachi, Shotaro; Sasaki, Mamoru; Tsutsumi, Akihiro; Irie, Hidehiro; Sakurai, Kaori; Sayama, Koichi; Nakamura, Hidetoshi; Asano, Koichiro; Betsuyaku, Tomoko; Fukunaga, Koichi.

In: Respiratory Medicine, Vol. 148, 01.03.2019, p. 13-23.

Research output: Contribution to journalArticle

Kameyama, N, Chubachi, S, Sasaki, M, Tsutsumi, A, Irie, H, Sakurai, K, Sayama, K, Nakamura, H, Asano, K, Betsuyaku, T & Fukunaga, K 2019, 'Predictive and modifying factors of bone mineral density decline in patients with COPD', Respiratory Medicine, vol. 148, pp. 13-23. https://doi.org/10.1016/j.rmed.2019.01.005
Kameyama, Naofumi ; Chubachi, Shotaro ; Sasaki, Mamoru ; Tsutsumi, Akihiro ; Irie, Hidehiro ; Sakurai, Kaori ; Sayama, Koichi ; Nakamura, Hidetoshi ; Asano, Koichiro ; Betsuyaku, Tomoko ; Fukunaga, Koichi. / Predictive and modifying factors of bone mineral density decline in patients with COPD. In: Respiratory Medicine. 2019 ; Vol. 148. pp. 13-23.
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