Predictive factors for severe and febrile neutropenia during docetaxel chemotherapy for castration-resistant prostate cancer

Keisuke Shigeta, Takeo Kosaka, Satoshi Yazawa, Yota Yasumizu, Ryuichi Mizuno, Hirohiko Nagata, Kazunobu Shinoda, Shinya Morita, Akira Miyajima, Eiji Kikuchi, Ken Nakagawa, Shintaro Hasegawa, Mototsugu Oya

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Abstract

Background: The aim of this study is to identify factors that increase the occurrence of severe neutropenia (SN) and febrile neutropenia (FN) during docetaxel treatment for castration-resistant prostate cancer (CRPC). Methods: We retrospectively reviewed 258 courses during the first three cycles among 95 patients. Docetaxel at a dose of 75 mg/m<sup>2</sup> was administered every 3 or 4 weeks. Patient background, laboratory data, and bone scan results were collected to assess predictive factors for SN and FN. We defined SN as an absolute neutrophil count (ANC) of <500/mm<sup>3</sup> and defined FN as an ANC of <1000/mm<sup>3</sup> with a body temperature of >38.3 °C. Results: The mean age of the patients was 72.6 ± 6.4 years and the mean prostate-specific antigen was 135.4 ± 290.9 ng/ml. During the first three courses of treatment, SN occurred in 72.6 % of patients and FN occurred in 9.5 % of patients. Univariate analysis demonstrated that age ≥75 years (p = 0.002), number of comorbidities ≥1.2 (p = 0.008 and p = 0.006) and previous external beam radiation therapy (EBRT) (p = 0.001) were predictive factors for the development of SN or FN. In multivariate analysis, significant predictors of SN or FN were age ≥75 years (hazard ratio [HR] 5.77; p = 0.004) and previous EBRT (HR 14.5; p = 0.012). According to the subgroup analysis dividing SN and FN separately, multivariate analysis also revealed that age ≥75 years and previous EBRT were also significant predictors for developing SN (HR 5.09; p = 0.023, HR 12.7; p = 0.020, respectively) and for developing FN (HR 5.45; p = 0.042, HR 7.72; p = 0.015, respectively). Conclusions: Patients aged ≥75 years and with a history of localized radiation therapy are at higher risk for significant neutropenic events and require closer surveillance.

Original languageEnglish
Pages (from-to)605-612
Number of pages8
JournalInternational Journal of Clinical Oncology
Volume20
Issue number3
DOIs
Publication statusPublished - 2015 Jun 11

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docetaxel
Febrile Neutropenia
Castration
Neutropenia
Prostatic Neoplasms
Drug Therapy
Radiotherapy
Multivariate Analysis
Prostate-Specific Antigen
Body Temperature

Keywords

  • Castration-resistant prostate cancer
  • Docetaxel
  • Febrile neutropenia
  • Predictive factor
  • Severe neutropenia

ASJC Scopus subject areas

  • Oncology
  • Surgery
  • Hematology

Cite this

Predictive factors for severe and febrile neutropenia during docetaxel chemotherapy for castration-resistant prostate cancer. / Shigeta, Keisuke; Kosaka, Takeo; Yazawa, Satoshi; Yasumizu, Yota; Mizuno, Ryuichi; Nagata, Hirohiko; Shinoda, Kazunobu; Morita, Shinya; Miyajima, Akira; Kikuchi, Eiji; Nakagawa, Ken; Hasegawa, Shintaro; Oya, Mototsugu.

In: International Journal of Clinical Oncology, Vol. 20, No. 3, 11.06.2015, p. 605-612.

Research output: Contribution to journalArticle

Shigeta, Keisuke ; Kosaka, Takeo ; Yazawa, Satoshi ; Yasumizu, Yota ; Mizuno, Ryuichi ; Nagata, Hirohiko ; Shinoda, Kazunobu ; Morita, Shinya ; Miyajima, Akira ; Kikuchi, Eiji ; Nakagawa, Ken ; Hasegawa, Shintaro ; Oya, Mototsugu. / Predictive factors for severe and febrile neutropenia during docetaxel chemotherapy for castration-resistant prostate cancer. In: International Journal of Clinical Oncology. 2015 ; Vol. 20, No. 3. pp. 605-612.
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abstract = "Background: The aim of this study is to identify factors that increase the occurrence of severe neutropenia (SN) and febrile neutropenia (FN) during docetaxel treatment for castration-resistant prostate cancer (CRPC). Methods: We retrospectively reviewed 258 courses during the first three cycles among 95 patients. Docetaxel at a dose of 75 mg/m2 was administered every 3 or 4 weeks. Patient background, laboratory data, and bone scan results were collected to assess predictive factors for SN and FN. We defined SN as an absolute neutrophil count (ANC) of <500/mm3 and defined FN as an ANC of <1000/mm3 with a body temperature of >38.3 °C. Results: The mean age of the patients was 72.6 ± 6.4 years and the mean prostate-specific antigen was 135.4 ± 290.9 ng/ml. During the first three courses of treatment, SN occurred in 72.6 {\%} of patients and FN occurred in 9.5 {\%} of patients. Univariate analysis demonstrated that age ≥75 years (p = 0.002), number of comorbidities ≥1.2 (p = 0.008 and p = 0.006) and previous external beam radiation therapy (EBRT) (p = 0.001) were predictive factors for the development of SN or FN. In multivariate analysis, significant predictors of SN or FN were age ≥75 years (hazard ratio [HR] 5.77; p = 0.004) and previous EBRT (HR 14.5; p = 0.012). According to the subgroup analysis dividing SN and FN separately, multivariate analysis also revealed that age ≥75 years and previous EBRT were also significant predictors for developing SN (HR 5.09; p = 0.023, HR 12.7; p = 0.020, respectively) and for developing FN (HR 5.45; p = 0.042, HR 7.72; p = 0.015, respectively). Conclusions: Patients aged ≥75 years and with a history of localized radiation therapy are at higher risk for significant neutropenic events and require closer surveillance.",
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author = "Keisuke Shigeta and Takeo Kosaka and Satoshi Yazawa and Yota Yasumizu and Ryuichi Mizuno and Hirohiko Nagata and Kazunobu Shinoda and Shinya Morita and Akira Miyajima and Eiji Kikuchi and Ken Nakagawa and Shintaro Hasegawa and Mototsugu Oya",
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T1 - Predictive factors for severe and febrile neutropenia during docetaxel chemotherapy for castration-resistant prostate cancer

AU - Shigeta, Keisuke

AU - Kosaka, Takeo

AU - Yazawa, Satoshi

AU - Yasumizu, Yota

AU - Mizuno, Ryuichi

AU - Nagata, Hirohiko

AU - Shinoda, Kazunobu

AU - Morita, Shinya

AU - Miyajima, Akira

AU - Kikuchi, Eiji

AU - Nakagawa, Ken

AU - Hasegawa, Shintaro

AU - Oya, Mototsugu

PY - 2015/6/11

Y1 - 2015/6/11

N2 - Background: The aim of this study is to identify factors that increase the occurrence of severe neutropenia (SN) and febrile neutropenia (FN) during docetaxel treatment for castration-resistant prostate cancer (CRPC). Methods: We retrospectively reviewed 258 courses during the first three cycles among 95 patients. Docetaxel at a dose of 75 mg/m2 was administered every 3 or 4 weeks. Patient background, laboratory data, and bone scan results were collected to assess predictive factors for SN and FN. We defined SN as an absolute neutrophil count (ANC) of <500/mm3 and defined FN as an ANC of <1000/mm3 with a body temperature of >38.3 °C. Results: The mean age of the patients was 72.6 ± 6.4 years and the mean prostate-specific antigen was 135.4 ± 290.9 ng/ml. During the first three courses of treatment, SN occurred in 72.6 % of patients and FN occurred in 9.5 % of patients. Univariate analysis demonstrated that age ≥75 years (p = 0.002), number of comorbidities ≥1.2 (p = 0.008 and p = 0.006) and previous external beam radiation therapy (EBRT) (p = 0.001) were predictive factors for the development of SN or FN. In multivariate analysis, significant predictors of SN or FN were age ≥75 years (hazard ratio [HR] 5.77; p = 0.004) and previous EBRT (HR 14.5; p = 0.012). According to the subgroup analysis dividing SN and FN separately, multivariate analysis also revealed that age ≥75 years and previous EBRT were also significant predictors for developing SN (HR 5.09; p = 0.023, HR 12.7; p = 0.020, respectively) and for developing FN (HR 5.45; p = 0.042, HR 7.72; p = 0.015, respectively). Conclusions: Patients aged ≥75 years and with a history of localized radiation therapy are at higher risk for significant neutropenic events and require closer surveillance.

AB - Background: The aim of this study is to identify factors that increase the occurrence of severe neutropenia (SN) and febrile neutropenia (FN) during docetaxel treatment for castration-resistant prostate cancer (CRPC). Methods: We retrospectively reviewed 258 courses during the first three cycles among 95 patients. Docetaxel at a dose of 75 mg/m2 was administered every 3 or 4 weeks. Patient background, laboratory data, and bone scan results were collected to assess predictive factors for SN and FN. We defined SN as an absolute neutrophil count (ANC) of <500/mm3 and defined FN as an ANC of <1000/mm3 with a body temperature of >38.3 °C. Results: The mean age of the patients was 72.6 ± 6.4 years and the mean prostate-specific antigen was 135.4 ± 290.9 ng/ml. During the first three courses of treatment, SN occurred in 72.6 % of patients and FN occurred in 9.5 % of patients. Univariate analysis demonstrated that age ≥75 years (p = 0.002), number of comorbidities ≥1.2 (p = 0.008 and p = 0.006) and previous external beam radiation therapy (EBRT) (p = 0.001) were predictive factors for the development of SN or FN. In multivariate analysis, significant predictors of SN or FN were age ≥75 years (hazard ratio [HR] 5.77; p = 0.004) and previous EBRT (HR 14.5; p = 0.012). According to the subgroup analysis dividing SN and FN separately, multivariate analysis also revealed that age ≥75 years and previous EBRT were also significant predictors for developing SN (HR 5.09; p = 0.023, HR 12.7; p = 0.020, respectively) and for developing FN (HR 5.45; p = 0.042, HR 7.72; p = 0.015, respectively). Conclusions: Patients aged ≥75 years and with a history of localized radiation therapy are at higher risk for significant neutropenic events and require closer surveillance.

KW - Castration-resistant prostate cancer

KW - Docetaxel

KW - Febrile neutropenia

KW - Predictive factor

KW - Severe neutropenia

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