Predictive factors of acute urinary retention requiring catheterization following 125I prostate brachytherapy

Toshio Ohashi, Atsunori Yorozu, Kazuhito Toya, Shiro Saito, Tetsuo Momma

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20 Citations (Scopus)

Abstract

Objective: To analyze predictive factors of acute urinary retention requiring catheterization after 125I prostate brachytherapy. Methods: A group of 227 consecutive patients with localized prostate ca ncer were treated with 125 I prostate brachytherapy between September 2003 and December 2004. The clinical, treatment-related and dosimetric factors were evaluated for the need for catheterization owing to urinary retention. Results: Twelve patients (5.3%) required catheterization. The median time to onset was 2 days after implantation (range 1-7 days). Univariate analysis demonstrated that pre-implant ultrasound prostate volume, number of seeds, number of needles and neoadjuvant hormonal manipulation were predictive for catheterization. In multivariate analysis, the number of needles and neoadjuvant hormonal manipulation were significant independent predictive factors for catheterization (P = 0.002 and 0.025, respectively). The risk of catheterization in the cluster in which the number of needles was >24 was 4.07 times as high as that in the cluster in which the number of needles was ≤24 [11.3% versus 3.0%, P = 0.020; 95% confidence interval (CI) 1.24-13.36], and the risk in the hormonally manipulated patients was 7.05 times as high as that in the hormone-naïve patients (7.7% versus 1.2%, P = 0.034; 95% CI 0.89-55.64). Conclusion: Our data suggest that the number of needles and hormonal manipulation might be the strongest predictors for catheterization.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalJapanese journal of clinical oncology
Volume36
Issue number5
DOIs
Publication statusPublished - 2006 May 1

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Keywords

  • Brachytherapy
  • Catheterization
  • Iodine-125
  • Prostate cancer
  • Urinary morbidity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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