Predictive factors of late cholangitis in patients undergoing pancreaticoduodenectomy

Yasuhiro Ito, Yuta Abe, Minoru Kitago, Osamu Itano, Yuukou Kitagawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Because the survival rate for patients experiencing late complications after pancreaticoduodenectomy (PD) is increasing, late complications should receive as much attention as early complications do. Methods: Between April 2007 and August 2016, 133 patients underwent PD at our institution. We analyzed their cases to determine the predictors of late cholangitis after PD. Results: Of the 133 patients, 28 (21.1%) were diagnosed with postoperative cholangitis. A multivariate analysis showed that abnormal postoperative values of alkaline phosphatase were independently associated with postoperative cholangitis (odds ratio, 3.81; 95% confidence interval, 1.519-9.553; P=0.004). The optimal cut-off value for postoperative alkaline phosphatase calculated from the receiver operating characteristic curve was 410IU/L (sensitivity, 76.2%; specificity, 67.9%; area under the curve, 0.73). A univariate analysis to identify risk factors showed that pneumobilia was significantly related to a postoperative alkaline phosphatase value ≥410IU/L (P=0.041). Conclusion: This study suggests that an alkaline phosphatase level ≥410IU/L is a predictor of late postoperative cholangitis. In addition, pneumobilia is also related to the postoperative alkaline phosphatase level. Therefore, alkaline phosphatase levels should be carefully monitored in patients with postoperative pneumobilia in the late postoperative course.

Original languageEnglish
Article number19
JournalWorld Journal of Surgical Oncology
Volume16
Issue number1
DOIs
Publication statusPublished - 2018 Jan 31

Fingerprint

Cholangitis
Pancreaticoduodenectomy
Alkaline Phosphatase
ROC Curve
Area Under Curve
Multivariate Analysis
Survival Rate
Odds Ratio
Confidence Intervals

Keywords

  • Alkaline phosphatase
  • Cholangitis
  • Late complication
  • Pancreaticoduodenectomy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Predictive factors of late cholangitis in patients undergoing pancreaticoduodenectomy. / Ito, Yasuhiro; Abe, Yuta; Kitago, Minoru; Itano, Osamu; Kitagawa, Yuukou.

In: World Journal of Surgical Oncology, Vol. 16, No. 1, 19, 31.01.2018.

Research output: Contribution to journalArticle

@article{83e4841bbb9f483690e0362fca496e4e,
title = "Predictive factors of late cholangitis in patients undergoing pancreaticoduodenectomy",
abstract = "Background: Because the survival rate for patients experiencing late complications after pancreaticoduodenectomy (PD) is increasing, late complications should receive as much attention as early complications do. Methods: Between April 2007 and August 2016, 133 patients underwent PD at our institution. We analyzed their cases to determine the predictors of late cholangitis after PD. Results: Of the 133 patients, 28 (21.1{\%}) were diagnosed with postoperative cholangitis. A multivariate analysis showed that abnormal postoperative values of alkaline phosphatase were independently associated with postoperative cholangitis (odds ratio, 3.81; 95{\%} confidence interval, 1.519-9.553; P=0.004). The optimal cut-off value for postoperative alkaline phosphatase calculated from the receiver operating characteristic curve was 410IU/L (sensitivity, 76.2{\%}; specificity, 67.9{\%}; area under the curve, 0.73). A univariate analysis to identify risk factors showed that pneumobilia was significantly related to a postoperative alkaline phosphatase value ≥410IU/L (P=0.041). Conclusion: This study suggests that an alkaline phosphatase level ≥410IU/L is a predictor of late postoperative cholangitis. In addition, pneumobilia is also related to the postoperative alkaline phosphatase level. Therefore, alkaline phosphatase levels should be carefully monitored in patients with postoperative pneumobilia in the late postoperative course.",
keywords = "Alkaline phosphatase, Cholangitis, Late complication, Pancreaticoduodenectomy",
author = "Yasuhiro Ito and Yuta Abe and Minoru Kitago and Osamu Itano and Yuukou Kitagawa",
year = "2018",
month = "1",
day = "31",
doi = "10.1186/s12957-017-1301-6",
language = "English",
volume = "16",
journal = "World Journal of Surgical Oncology",
issn = "1477-7819",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Predictive factors of late cholangitis in patients undergoing pancreaticoduodenectomy

AU - Ito, Yasuhiro

AU - Abe, Yuta

AU - Kitago, Minoru

AU - Itano, Osamu

AU - Kitagawa, Yuukou

PY - 2018/1/31

Y1 - 2018/1/31

N2 - Background: Because the survival rate for patients experiencing late complications after pancreaticoduodenectomy (PD) is increasing, late complications should receive as much attention as early complications do. Methods: Between April 2007 and August 2016, 133 patients underwent PD at our institution. We analyzed their cases to determine the predictors of late cholangitis after PD. Results: Of the 133 patients, 28 (21.1%) were diagnosed with postoperative cholangitis. A multivariate analysis showed that abnormal postoperative values of alkaline phosphatase were independently associated with postoperative cholangitis (odds ratio, 3.81; 95% confidence interval, 1.519-9.553; P=0.004). The optimal cut-off value for postoperative alkaline phosphatase calculated from the receiver operating characteristic curve was 410IU/L (sensitivity, 76.2%; specificity, 67.9%; area under the curve, 0.73). A univariate analysis to identify risk factors showed that pneumobilia was significantly related to a postoperative alkaline phosphatase value ≥410IU/L (P=0.041). Conclusion: This study suggests that an alkaline phosphatase level ≥410IU/L is a predictor of late postoperative cholangitis. In addition, pneumobilia is also related to the postoperative alkaline phosphatase level. Therefore, alkaline phosphatase levels should be carefully monitored in patients with postoperative pneumobilia in the late postoperative course.

AB - Background: Because the survival rate for patients experiencing late complications after pancreaticoduodenectomy (PD) is increasing, late complications should receive as much attention as early complications do. Methods: Between April 2007 and August 2016, 133 patients underwent PD at our institution. We analyzed their cases to determine the predictors of late cholangitis after PD. Results: Of the 133 patients, 28 (21.1%) were diagnosed with postoperative cholangitis. A multivariate analysis showed that abnormal postoperative values of alkaline phosphatase were independently associated with postoperative cholangitis (odds ratio, 3.81; 95% confidence interval, 1.519-9.553; P=0.004). The optimal cut-off value for postoperative alkaline phosphatase calculated from the receiver operating characteristic curve was 410IU/L (sensitivity, 76.2%; specificity, 67.9%; area under the curve, 0.73). A univariate analysis to identify risk factors showed that pneumobilia was significantly related to a postoperative alkaline phosphatase value ≥410IU/L (P=0.041). Conclusion: This study suggests that an alkaline phosphatase level ≥410IU/L is a predictor of late postoperative cholangitis. In addition, pneumobilia is also related to the postoperative alkaline phosphatase level. Therefore, alkaline phosphatase levels should be carefully monitored in patients with postoperative pneumobilia in the late postoperative course.

KW - Alkaline phosphatase

KW - Cholangitis

KW - Late complication

KW - Pancreaticoduodenectomy

UR - http://www.scopus.com/inward/record.url?scp=85041631854&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041631854&partnerID=8YFLogxK

U2 - 10.1186/s12957-017-1301-6

DO - 10.1186/s12957-017-1301-6

M3 - Article

C2 - 29386043

AN - SCOPUS:85041631854

VL - 16

JO - World Journal of Surgical Oncology

JF - World Journal of Surgical Oncology

SN - 1477-7819

IS - 1

M1 - 19

ER -