Predictive factors of rectal toxicity after permanent iodine-125 seed implantation: Prospective cohort study in 2339 patients

Norihisa Katayama, Atsunori Yorozu, Shinichiro Maruo, Shinsuke Kojima, Toshio Ohashi, Nobumichi Tanaka, Takashi Kikuchi, Satoshi Higashide, Shiro Saito, Takushi Dokiya, Masanori Fukushima, Hidetoshi Yamanaka

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate the incidence and the associated factors of rectal toxicity in patients with prostate cancer undergoing permanent seed implantation (PI) with or without external beam radiation therapy (EBRT) in a nationwide prospective cohort study in Japan (J-POPS) during the first 2,years. Methods and Materials: A total of 2,339 subjects were available for the analyses. Rectal toxicity was evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. Results: The 3-year cumulative incidence for grade ≥2 rectal toxicity was 2.88%, 1.76%, and 6.53% in all subjects, PI group and EBRT combination therapy group, respectively. On multivariate analysis, among all subjects, grade ≥2 rectal toxicity was associated with rectal volumes receiving 100% of the prescribed dose (R 100 ; p,<,0.0001) and EBRT combination therapy (p,=,0.0066). R 100 in the PI group (p,=,0.0254), and R 100 (p,=,0.0011) and interactive planning (p,=,0.0267) in the EBRT combination therapy group were also associated with grade ≥2 toxicity. The 3-year cumulative incidence of grade ≥2 rectal toxicity was 3.80% and 1.37% for R 100 ,≥,1,mL and R 100 ,<,1,mL, respectively, in the PI group (p,=,0.0068), and 14.09% and 5.52% for R 100 ,≥,1,mL and R 100 ,<,1,mL, respectively, in the EBRT combination therapy group (p,=,0.0070). Conclusions: Rectal toxicity was relatively rare in this study compared with previous reports. For Japanese prostate cancer patients, R 100 ,<,1,mL in both PI and EBRT combination therapy groups and interactive planning in EBRT combination therapy group may be effective in decreasing the incidence of rectal toxicity.

Original languageEnglish
JournalBrachytherapy
DOIs
Publication statusAccepted/In press - 2016 Jul 9

Fingerprint

Iodine
Seeds
Cohort Studies
Radiotherapy
Group Psychotherapy
Prospective Studies
Incidence
Prostatic Neoplasms
National Cancer Institute (U.S.)
Terminology
Japan
Multivariate Analysis

Keywords

  • Brachytherapy
  • Dose-volume histogram parameters
  • External beam radiation therapy
  • Interactive planning
  • Prostate cancer
  • Rectal toxicity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Predictive factors of rectal toxicity after permanent iodine-125 seed implantation : Prospective cohort study in 2339 patients. / Katayama, Norihisa; Yorozu, Atsunori; Maruo, Shinichiro; Kojima, Shinsuke; Ohashi, Toshio; Tanaka, Nobumichi; Kikuchi, Takashi; Higashide, Satoshi; Saito, Shiro; Dokiya, Takushi; Fukushima, Masanori; Yamanaka, Hidetoshi.

In: Brachytherapy, 09.07.2016.

Research output: Contribution to journalArticle

Katayama, N, Yorozu, A, Maruo, S, Kojima, S, Ohashi, T, Tanaka, N, Kikuchi, T, Higashide, S, Saito, S, Dokiya, T, Fukushima, M & Yamanaka, H 2016, 'Predictive factors of rectal toxicity after permanent iodine-125 seed implantation: Prospective cohort study in 2339 patients', Brachytherapy. https://doi.org/10.1016/j.brachy.2016.09.001
Katayama, Norihisa ; Yorozu, Atsunori ; Maruo, Shinichiro ; Kojima, Shinsuke ; Ohashi, Toshio ; Tanaka, Nobumichi ; Kikuchi, Takashi ; Higashide, Satoshi ; Saito, Shiro ; Dokiya, Takushi ; Fukushima, Masanori ; Yamanaka, Hidetoshi. / Predictive factors of rectal toxicity after permanent iodine-125 seed implantation : Prospective cohort study in 2339 patients. In: Brachytherapy. 2016.
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abstract = "Purpose: To evaluate the incidence and the associated factors of rectal toxicity in patients with prostate cancer undergoing permanent seed implantation (PI) with or without external beam radiation therapy (EBRT) in a nationwide prospective cohort study in Japan (J-POPS) during the first 2,years. Methods and Materials: A total of 2,339 subjects were available for the analyses. Rectal toxicity was evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. Results: The 3-year cumulative incidence for grade ≥2 rectal toxicity was 2.88{\%}, 1.76{\%}, and 6.53{\%} in all subjects, PI group and EBRT combination therapy group, respectively. On multivariate analysis, among all subjects, grade ≥2 rectal toxicity was associated with rectal volumes receiving 100{\%} of the prescribed dose (R 100 ; p,<,0.0001) and EBRT combination therapy (p,=,0.0066). R 100 in the PI group (p,=,0.0254), and R 100 (p,=,0.0011) and interactive planning (p,=,0.0267) in the EBRT combination therapy group were also associated with grade ≥2 toxicity. The 3-year cumulative incidence of grade ≥2 rectal toxicity was 3.80{\%} and 1.37{\%} for R 100 ,≥,1,mL and R 100 ,<,1,mL, respectively, in the PI group (p,=,0.0068), and 14.09{\%} and 5.52{\%} for R 100 ,≥,1,mL and R 100 ,<,1,mL, respectively, in the EBRT combination therapy group (p,=,0.0070). Conclusions: Rectal toxicity was relatively rare in this study compared with previous reports. For Japanese prostate cancer patients, R 100 ,<,1,mL in both PI and EBRT combination therapy groups and interactive planning in EBRT combination therapy group may be effective in decreasing the incidence of rectal toxicity.",
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author = "Norihisa Katayama and Atsunori Yorozu and Shinichiro Maruo and Shinsuke Kojima and Toshio Ohashi and Nobumichi Tanaka and Takashi Kikuchi and Satoshi Higashide and Shiro Saito and Takushi Dokiya and Masanori Fukushima and Hidetoshi Yamanaka",
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AU - Katayama, Norihisa

AU - Yorozu, Atsunori

AU - Maruo, Shinichiro

AU - Kojima, Shinsuke

AU - Ohashi, Toshio

AU - Tanaka, Nobumichi

AU - Kikuchi, Takashi

AU - Higashide, Satoshi

AU - Saito, Shiro

AU - Dokiya, Takushi

AU - Fukushima, Masanori

AU - Yamanaka, Hidetoshi

PY - 2016/7/9

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N2 - Purpose: To evaluate the incidence and the associated factors of rectal toxicity in patients with prostate cancer undergoing permanent seed implantation (PI) with or without external beam radiation therapy (EBRT) in a nationwide prospective cohort study in Japan (J-POPS) during the first 2,years. Methods and Materials: A total of 2,339 subjects were available for the analyses. Rectal toxicity was evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. Results: The 3-year cumulative incidence for grade ≥2 rectal toxicity was 2.88%, 1.76%, and 6.53% in all subjects, PI group and EBRT combination therapy group, respectively. On multivariate analysis, among all subjects, grade ≥2 rectal toxicity was associated with rectal volumes receiving 100% of the prescribed dose (R 100 ; p,<,0.0001) and EBRT combination therapy (p,=,0.0066). R 100 in the PI group (p,=,0.0254), and R 100 (p,=,0.0011) and interactive planning (p,=,0.0267) in the EBRT combination therapy group were also associated with grade ≥2 toxicity. The 3-year cumulative incidence of grade ≥2 rectal toxicity was 3.80% and 1.37% for R 100 ,≥,1,mL and R 100 ,<,1,mL, respectively, in the PI group (p,=,0.0068), and 14.09% and 5.52% for R 100 ,≥,1,mL and R 100 ,<,1,mL, respectively, in the EBRT combination therapy group (p,=,0.0070). Conclusions: Rectal toxicity was relatively rare in this study compared with previous reports. For Japanese prostate cancer patients, R 100 ,<,1,mL in both PI and EBRT combination therapy groups and interactive planning in EBRT combination therapy group may be effective in decreasing the incidence of rectal toxicity.

AB - Purpose: To evaluate the incidence and the associated factors of rectal toxicity in patients with prostate cancer undergoing permanent seed implantation (PI) with or without external beam radiation therapy (EBRT) in a nationwide prospective cohort study in Japan (J-POPS) during the first 2,years. Methods and Materials: A total of 2,339 subjects were available for the analyses. Rectal toxicity was evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. Results: The 3-year cumulative incidence for grade ≥2 rectal toxicity was 2.88%, 1.76%, and 6.53% in all subjects, PI group and EBRT combination therapy group, respectively. On multivariate analysis, among all subjects, grade ≥2 rectal toxicity was associated with rectal volumes receiving 100% of the prescribed dose (R 100 ; p,<,0.0001) and EBRT combination therapy (p,=,0.0066). R 100 in the PI group (p,=,0.0254), and R 100 (p,=,0.0011) and interactive planning (p,=,0.0267) in the EBRT combination therapy group were also associated with grade ≥2 toxicity. The 3-year cumulative incidence of grade ≥2 rectal toxicity was 3.80% and 1.37% for R 100 ,≥,1,mL and R 100 ,<,1,mL, respectively, in the PI group (p,=,0.0068), and 14.09% and 5.52% for R 100 ,≥,1,mL and R 100 ,<,1,mL, respectively, in the EBRT combination therapy group (p,=,0.0070). Conclusions: Rectal toxicity was relatively rare in this study compared with previous reports. For Japanese prostate cancer patients, R 100 ,<,1,mL in both PI and EBRT combination therapy groups and interactive planning in EBRT combination therapy group may be effective in decreasing the incidence of rectal toxicity.

KW - Brachytherapy

KW - Dose-volume histogram parameters

KW - External beam radiation therapy

KW - Interactive planning

KW - Prostate cancer

KW - Rectal toxicity

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