Predictive factors of response to leukocytapheresis therapy for ulcerative colitis

Tomoharu Yajima, Hiromasa Takaishi, Takanori Kanai, Yasushi Iwao, Mamoru Watanabe, Hiromasa Ishii, Toshifumi Hibi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Leukocytapheresis (LCAP) using a leukocyte removal filter was performed for 8 patients with moderate to severe ulcerative colitis (UC). Significant clinical improvement was attained in 5 of 8 patients (62.5%). All of them had been suffering from moderately active colitis and received corticosteroid therapy. On the other hand, 3 patients with severely active disease and treated with little or no corticosteroid were resistant to LCAP. This result indicates that LCAP is an effective treatment for steroid-resistant cases of UC when combined with steroid therapy. LCAP alone, however, seems to have little efficacy for severely active UC.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalTherapeutic Apheresis
Volume2
Issue number2
DOIs
Publication statusPublished - 1998 May

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Keywords

  • Leukocytapheresis
  • Steroid resistant therapy
  • Ulcerative colitis

ASJC Scopus subject areas

  • Medicine(all)

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