Predictive factors of response to leukocytapheresis therapy for ulcerative colitis

Tomoharu Yajima, Hiromasa Takaishi, Takanori Kanai, Yasushi Iwao, Mamoru Watanabe, Hiromasa Ishii, Toshifumi Hibi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Leukocytapheresis (LCAP) using a leukocyte removal filter was performed for 8 patients with moderate to severe ulcerative colitis (UC). Significant clinical improvement was attained in 5 of 8 patients (62.5%). All of them had been suffering from moderately active colitis and received corticosteroid therapy. On the other hand, 3 patients with severely active disease and treated with little or no corticosteroid were resistant to LCAP. This result indicates that LCAP is an effective treatment for steroid-resistant cases of UC when combined with steroid therapy. LCAP alone, however, seems to have little efficacy for severely active UC.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalTherapeutic Apheresis
Volume2
Issue number2
Publication statusPublished - 1998 May

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Leukapheresis
Ulcerative Colitis
Adrenal Cortex Hormones
Steroids
Colitis
Therapeutics
Leukocytes

Keywords

  • Leukocytapheresis
  • Steroid resistant therapy
  • Ulcerative colitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Predictive factors of response to leukocytapheresis therapy for ulcerative colitis. / Yajima, Tomoharu; Takaishi, Hiromasa; Kanai, Takanori; Iwao, Yasushi; Watanabe, Mamoru; Ishii, Hiromasa; Hibi, Toshifumi.

In: Therapeutic Apheresis, Vol. 2, No. 2, 05.1998, p. 115-119.

Research output: Contribution to journalArticle

Yajima, Tomoharu ; Takaishi, Hiromasa ; Kanai, Takanori ; Iwao, Yasushi ; Watanabe, Mamoru ; Ishii, Hiromasa ; Hibi, Toshifumi. / Predictive factors of response to leukocytapheresis therapy for ulcerative colitis. In: Therapeutic Apheresis. 1998 ; Vol. 2, No. 2. pp. 115-119.
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