Predictive model for survival after liver resection for noncolorectal liver metastases in the modern era: a Japanese multicenter analysis

Taiga Wakabayashi, Taizo Hibi, Godai Yoneda, Yasuhito Iwao, Yu Sawada, Hiroyuki Hoshino, Shuichiro Uemura, Daisuke Ban, Atsushi Kudo, Yusuke Takemura, Kohei Mishima, Masahiro Shinoda, Osamu Itano, Takehito Otsubo, Itaru Endo, Yuko Kitagawa, Minoru Tanabe, Hiroto Egawa, Masakazu Yamamoto

Research output: Contribution to journalArticle

Abstract

Background: Survival benefit of liver resection for noncolorectal liver metastases (NCRLM) remains to be defined. Methods: This multicenter, retrospective cohort analysis included consecutive patients with NCRLM whose primary tumor and all metastases were treated with curative intent between 2000 and 2013. The primary endpoint was 5-year overall survival. Clinicopathological factors that affected prognoses were identified using multivariate Cox regression analyses and were included in a predictive model. Results: Data for 205 patients were analyzed. The three most common primary tumor sites were stomach (39%), pancreas (13%), and urinary tract (10%), with adenocarcinomas the main pathology (52%). R0 resection was achieved in 85%, and the overall survival at 5 years was 41%. In the multivariate analysis, synchronous liver metastases, R1/2 resection, and adenocarcinomas and other carcinomas (with gastrointestinal stromal tumors, neuroendocrine tumors G1/G2, and sarcomas set as the reference group) were independent negative indicators of overall survival. A predictive model effectively stratified the NCRLM patients into low-, intermediate-, and high-risk groups with overall 5-year survival rates of 63%, 38%, and 21%, respectively (P < 0.001). Conclusions: Patients who underwent curative resection for metachronous disease and favorable tumor pathology are expected to have better survival in the NCRLM cohort.

Original languageEnglish
Pages (from-to)441-448
Number of pages8
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume26
Issue number10
DOIs
Publication statusPublished - 2019 Oct 1

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Neoplasm Metastasis
Survival
Liver
Adenocarcinoma
Pathology
Neoplasms
Gastrointestinal Stromal Tumors
Neuroendocrine Tumors
Urinary Tract
Sarcoma
Pancreas
Stomach
Cohort Studies
Multivariate Analysis
Survival Rate
Regression Analysis
Carcinoma

Keywords

  • Gastric carcinoma
  • Liver resection
  • Noncolorectal liver metastasis
  • Pancreatic carcinoma
  • Survival rate

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Predictive model for survival after liver resection for noncolorectal liver metastases in the modern era : a Japanese multicenter analysis. / Wakabayashi, Taiga; Hibi, Taizo; Yoneda, Godai; Iwao, Yasuhito; Sawada, Yu; Hoshino, Hiroyuki; Uemura, Shuichiro; Ban, Daisuke; Kudo, Atsushi; Takemura, Yusuke; Mishima, Kohei; Shinoda, Masahiro; Itano, Osamu; Otsubo, Takehito; Endo, Itaru; Kitagawa, Yuko; Tanabe, Minoru; Egawa, Hiroto; Yamamoto, Masakazu.

In: Journal of Hepato-Biliary-Pancreatic Sciences, Vol. 26, No. 10, 01.10.2019, p. 441-448.

Research output: Contribution to journalArticle

Wakabayashi, T, Hibi, T, Yoneda, G, Iwao, Y, Sawada, Y, Hoshino, H, Uemura, S, Ban, D, Kudo, A, Takemura, Y, Mishima, K, Shinoda, M, Itano, O, Otsubo, T, Endo, I, Kitagawa, Y, Tanabe, M, Egawa, H & Yamamoto, M 2019, 'Predictive model for survival after liver resection for noncolorectal liver metastases in the modern era: a Japanese multicenter analysis', Journal of Hepato-Biliary-Pancreatic Sciences, vol. 26, no. 10, pp. 441-448. https://doi.org/10.1002/jhbp.654
Wakabayashi, Taiga ; Hibi, Taizo ; Yoneda, Godai ; Iwao, Yasuhito ; Sawada, Yu ; Hoshino, Hiroyuki ; Uemura, Shuichiro ; Ban, Daisuke ; Kudo, Atsushi ; Takemura, Yusuke ; Mishima, Kohei ; Shinoda, Masahiro ; Itano, Osamu ; Otsubo, Takehito ; Endo, Itaru ; Kitagawa, Yuko ; Tanabe, Minoru ; Egawa, Hiroto ; Yamamoto, Masakazu. / Predictive model for survival after liver resection for noncolorectal liver metastases in the modern era : a Japanese multicenter analysis. In: Journal of Hepato-Biliary-Pancreatic Sciences. 2019 ; Vol. 26, No. 10. pp. 441-448.
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abstract = "Background: Survival benefit of liver resection for noncolorectal liver metastases (NCRLM) remains to be defined. Methods: This multicenter, retrospective cohort analysis included consecutive patients with NCRLM whose primary tumor and all metastases were treated with curative intent between 2000 and 2013. The primary endpoint was 5-year overall survival. Clinicopathological factors that affected prognoses were identified using multivariate Cox regression analyses and were included in a predictive model. Results: Data for 205 patients were analyzed. The three most common primary tumor sites were stomach (39{\%}), pancreas (13{\%}), and urinary tract (10{\%}), with adenocarcinomas the main pathology (52{\%}). R0 resection was achieved in 85{\%}, and the overall survival at 5 years was 41{\%}. In the multivariate analysis, synchronous liver metastases, R1/2 resection, and adenocarcinomas and other carcinomas (with gastrointestinal stromal tumors, neuroendocrine tumors G1/G2, and sarcomas set as the reference group) were independent negative indicators of overall survival. A predictive model effectively stratified the NCRLM patients into low-, intermediate-, and high-risk groups with overall 5-year survival rates of 63{\%}, 38{\%}, and 21{\%}, respectively (P < 0.001). Conclusions: Patients who underwent curative resection for metachronous disease and favorable tumor pathology are expected to have better survival in the NCRLM cohort.",
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T1 - Predictive model for survival after liver resection for noncolorectal liver metastases in the modern era

T2 - a Japanese multicenter analysis

AU - Wakabayashi, Taiga

AU - Hibi, Taizo

AU - Yoneda, Godai

AU - Iwao, Yasuhito

AU - Sawada, Yu

AU - Hoshino, Hiroyuki

AU - Uemura, Shuichiro

AU - Ban, Daisuke

AU - Kudo, Atsushi

AU - Takemura, Yusuke

AU - Mishima, Kohei

AU - Shinoda, Masahiro

AU - Itano, Osamu

AU - Otsubo, Takehito

AU - Endo, Itaru

AU - Kitagawa, Yuko

AU - Tanabe, Minoru

AU - Egawa, Hiroto

AU - Yamamoto, Masakazu

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Survival benefit of liver resection for noncolorectal liver metastases (NCRLM) remains to be defined. Methods: This multicenter, retrospective cohort analysis included consecutive patients with NCRLM whose primary tumor and all metastases were treated with curative intent between 2000 and 2013. The primary endpoint was 5-year overall survival. Clinicopathological factors that affected prognoses were identified using multivariate Cox regression analyses and were included in a predictive model. Results: Data for 205 patients were analyzed. The three most common primary tumor sites were stomach (39%), pancreas (13%), and urinary tract (10%), with adenocarcinomas the main pathology (52%). R0 resection was achieved in 85%, and the overall survival at 5 years was 41%. In the multivariate analysis, synchronous liver metastases, R1/2 resection, and adenocarcinomas and other carcinomas (with gastrointestinal stromal tumors, neuroendocrine tumors G1/G2, and sarcomas set as the reference group) were independent negative indicators of overall survival. A predictive model effectively stratified the NCRLM patients into low-, intermediate-, and high-risk groups with overall 5-year survival rates of 63%, 38%, and 21%, respectively (P < 0.001). Conclusions: Patients who underwent curative resection for metachronous disease and favorable tumor pathology are expected to have better survival in the NCRLM cohort.

AB - Background: Survival benefit of liver resection for noncolorectal liver metastases (NCRLM) remains to be defined. Methods: This multicenter, retrospective cohort analysis included consecutive patients with NCRLM whose primary tumor and all metastases were treated with curative intent between 2000 and 2013. The primary endpoint was 5-year overall survival. Clinicopathological factors that affected prognoses were identified using multivariate Cox regression analyses and were included in a predictive model. Results: Data for 205 patients were analyzed. The three most common primary tumor sites were stomach (39%), pancreas (13%), and urinary tract (10%), with adenocarcinomas the main pathology (52%). R0 resection was achieved in 85%, and the overall survival at 5 years was 41%. In the multivariate analysis, synchronous liver metastases, R1/2 resection, and adenocarcinomas and other carcinomas (with gastrointestinal stromal tumors, neuroendocrine tumors G1/G2, and sarcomas set as the reference group) were independent negative indicators of overall survival. A predictive model effectively stratified the NCRLM patients into low-, intermediate-, and high-risk groups with overall 5-year survival rates of 63%, 38%, and 21%, respectively (P < 0.001). Conclusions: Patients who underwent curative resection for metachronous disease and favorable tumor pathology are expected to have better survival in the NCRLM cohort.

KW - Gastric carcinoma

KW - Liver resection

KW - Noncolorectal liver metastasis

KW - Pancreatic carcinoma

KW - Survival rate

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