Predictive value for mortality of the double product at rest obtained by home blood pressure measurement: The ohasama study

Ryusuke Inoue, Takayoshi Ohkubo, Masahiro Kikuya, Hirohito Metoki, Kei Asayama, Atsuhiro Kanno, Taku Obara, Takuo Hirose, Azusa Hara, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yoshiaki Kondo, Yutaka Imai

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality. Methods HBP data of 2,583 participants from a Japanese general population (40% men) ≥35 years of age (mean, 59 years) without a history of cardiovascular disease (CVD) were obtained. The prognostic significance for a 1,000 mm Hg × beats/min elevation in the DP was determined by Cox proportional hazard regression analysis. The association between mortality and the DP was compared to that between mortality and the SBP or the PR using the likelihood ratio (LR) test. Results During a mean follow-up of 12.0 years, 454 total deaths, 153 CVD deaths (85 cardiac diseases, 68 strokes), and 301 non-CVD deaths occurred. The DP was positively and significantly associated with total, CVD, cardiac, stroke, and non-CVD mortality. The LR test showed that the DP was more strongly associated with total mortality, mortality from cardiac disease, and non-CVD than SBP. Similarly, the DP was more strongly associated with total death, CVD death, and death from stroke than PR. Conclusions The home DP was significantly associated with mortality, and the LR test indicated that the association between the DP and mortality would be stronger than that between mortality and SBP or PR. These findings are preliminary, and further study is needed to confirm the usefulness of the DP in risk stratification.

Original languageEnglish
Pages (from-to)568-575
Number of pages8
JournalAmerican journal of hypertension
Volume25
Issue number5
DOIs
Publication statusPublished - 2012 May 1
Externally publishedYes

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Blood Pressure
Mortality
Cardiovascular Diseases
Heart Rate
Heart Diseases
Stroke
Myocardial Infarction
Regression Analysis
Population

Keywords

  • blood pressure
  • double product/rate pressure product
  • general population
  • home blood pressure measurement
  • hypertension
  • mortality

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Predictive value for mortality of the double product at rest obtained by home blood pressure measurement : The ohasama study. / Inoue, Ryusuke; Ohkubo, Takayoshi; Kikuya, Masahiro; Metoki, Hirohito; Asayama, Kei; Kanno, Atsuhiro; Obara, Taku; Hirose, Takuo; Hara, Azusa; Hoshi, Haruhisa; Totsune, Kazuhito; Satoh, Hiroshi; Kondo, Yoshiaki; Imai, Yutaka.

In: American journal of hypertension, Vol. 25, No. 5, 01.05.2012, p. 568-575.

Research output: Contribution to journalArticle

Inoue, R, Ohkubo, T, Kikuya, M, Metoki, H, Asayama, K, Kanno, A, Obara, T, Hirose, T, Hara, A, Hoshi, H, Totsune, K, Satoh, H, Kondo, Y & Imai, Y 2012, 'Predictive value for mortality of the double product at rest obtained by home blood pressure measurement: The ohasama study', American journal of hypertension, vol. 25, no. 5, pp. 568-575. https://doi.org/10.1038/ajh.2012.3
Inoue, Ryusuke ; Ohkubo, Takayoshi ; Kikuya, Masahiro ; Metoki, Hirohito ; Asayama, Kei ; Kanno, Atsuhiro ; Obara, Taku ; Hirose, Takuo ; Hara, Azusa ; Hoshi, Haruhisa ; Totsune, Kazuhito ; Satoh, Hiroshi ; Kondo, Yoshiaki ; Imai, Yutaka. / Predictive value for mortality of the double product at rest obtained by home blood pressure measurement : The ohasama study. In: American journal of hypertension. 2012 ; Vol. 25, No. 5. pp. 568-575.
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T1 - Predictive value for mortality of the double product at rest obtained by home blood pressure measurement

T2 - The ohasama study

AU - Inoue, Ryusuke

AU - Ohkubo, Takayoshi

AU - Kikuya, Masahiro

AU - Metoki, Hirohito

AU - Asayama, Kei

AU - Kanno, Atsuhiro

AU - Obara, Taku

AU - Hirose, Takuo

AU - Hara, Azusa

AU - Hoshi, Haruhisa

AU - Totsune, Kazuhito

AU - Satoh, Hiroshi

AU - Kondo, Yoshiaki

AU - Imai, Yutaka

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Y1 - 2012/5/1

N2 - Background To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality. Methods HBP data of 2,583 participants from a Japanese general population (40% men) ≥35 years of age (mean, 59 years) without a history of cardiovascular disease (CVD) were obtained. The prognostic significance for a 1,000 mm Hg × beats/min elevation in the DP was determined by Cox proportional hazard regression analysis. The association between mortality and the DP was compared to that between mortality and the SBP or the PR using the likelihood ratio (LR) test. Results During a mean follow-up of 12.0 years, 454 total deaths, 153 CVD deaths (85 cardiac diseases, 68 strokes), and 301 non-CVD deaths occurred. The DP was positively and significantly associated with total, CVD, cardiac, stroke, and non-CVD mortality. The LR test showed that the DP was more strongly associated with total mortality, mortality from cardiac disease, and non-CVD than SBP. Similarly, the DP was more strongly associated with total death, CVD death, and death from stroke than PR. Conclusions The home DP was significantly associated with mortality, and the LR test indicated that the association between the DP and mortality would be stronger than that between mortality and SBP or PR. These findings are preliminary, and further study is needed to confirm the usefulness of the DP in risk stratification.

AB - Background To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality. Methods HBP data of 2,583 participants from a Japanese general population (40% men) ≥35 years of age (mean, 59 years) without a history of cardiovascular disease (CVD) were obtained. The prognostic significance for a 1,000 mm Hg × beats/min elevation in the DP was determined by Cox proportional hazard regression analysis. The association between mortality and the DP was compared to that between mortality and the SBP or the PR using the likelihood ratio (LR) test. Results During a mean follow-up of 12.0 years, 454 total deaths, 153 CVD deaths (85 cardiac diseases, 68 strokes), and 301 non-CVD deaths occurred. The DP was positively and significantly associated with total, CVD, cardiac, stroke, and non-CVD mortality. The LR test showed that the DP was more strongly associated with total mortality, mortality from cardiac disease, and non-CVD than SBP. Similarly, the DP was more strongly associated with total death, CVD death, and death from stroke than PR. Conclusions The home DP was significantly associated with mortality, and the LR test indicated that the association between the DP and mortality would be stronger than that between mortality and SBP or PR. These findings are preliminary, and further study is needed to confirm the usefulness of the DP in risk stratification.

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KW - hypertension

KW - mortality

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