Predictive value of CD24 and CD44 for neoadjuvant chemotherapy response and prognosis in primary breast cancer patients

Kazumi Horiguchi, Masakazu Toi, Shin Ichiro Horiguchi, Masahiro Sugimoto, Yasuhiro Naito, Yukiko Hayashi, Takayuki Ueno, Shinji Ohno, Nobuaki Funata, Katsumasa Kuroi, Masaru Tomita, Yoshinobu Eishi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: We investigated the significance of CD24 and CD44 expression for predicting responses to chemotherapy and prognosis in primary breast cancer patients. Patients and Methods: Diagnosis of breast cancer was confirmed by core needle biopsy, and immunohistochemical studies were performed. Preoperatively, patients received anthracyclinecontaining chemotherapy. Expression of CD44 and CD24 was assessed immunohistochemically and the relationship with chemotherapy response and with prognosis was analyzed. Results: Between 2001 and 2004, 139 women were enrolled in this study. In the correlation analysis, CD24 expression was negatively associated with pathological response to chemotherapy (p=0.0003). A machine learning technique with an alternating decision tree (ADTree) showed that four logical rules are involved in predicting the response depending on the combination of CD24, HER2, tumor stage, CD44, progesterone receptor, and patient age. In the survival analysis, patients having CD44 (++) showed a significantly favorable prognosis as compared with others (p=0.0002). A multivariate analysis showed that CD44 expression had an independent prognostic value (p<0.001). Conclusion: We found a significant correlation between CD44 expression and prognosis and between CD24 expression and response to chemotherapy. CD24 and CD44 expressions would be useful predictive markers, although further studies are needed.

Original languageEnglish
Pages (from-to)165-175
Number of pages11
JournalJournal of Medical and Dental Sciences
Volume57
Issue number2
Publication statusPublished - 2010 Jun 1

Keywords

  • Breast cancer
  • CD24
  • CD44
  • Prognosis
  • Response

ASJC Scopus subject areas

  • Dentistry(all)

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    Horiguchi, K., Toi, M., Horiguchi, S. I., Sugimoto, M., Naito, Y., Hayashi, Y., Ueno, T., Ohno, S., Funata, N., Kuroi, K., Tomita, M., & Eishi, Y. (2010). Predictive value of CD24 and CD44 for neoadjuvant chemotherapy response and prognosis in primary breast cancer patients. Journal of Medical and Dental Sciences, 57(2), 165-175.