Predictors of 90-day mortality after congenital heart surgery

The first report of risk models from a Japanese database

Hiroaki Miyata, Arata Murakami, Ai Tomotaki, Tetsuhiro Takaoka, Takeshi Konuma, Goki Matsumura, Syunji Sano, Shinichi Takamoto

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective The purpose of this study was to develop risk models for congenital heart surgery short-term and midterm outcomes from a nationwide integrated database drawn from hospitals in Japan.

Methods The Japan Congenital Cardiovascular Surgery Database collects clinical information from institutions throughout Japan specializing in congenital heart surgery. Variables and definitions used in the Japan Congenital Cardiovascular Surgery Database are almost identical to those of the Society of Thoracic Surgeons-European Association for Cardiothoracic Surgery database for congenital heart surgery. We used logistic regression to develop risk models, which were then validated through spilt-sample validation. In addition to procedural complexity categories by Risk Adjustment in Congenital Heart Surgery (RACHS-1) score, we incorporated patient characteristics to predict surgical outcome.

Results Among 8923 congenital heart operations performed at 69 sites with cardiac surgical programs, 30-day mortalities by RACHS-1 category were as follows: I, 0.1% (n = 1319); II, 0.5% (n = 3211); III, 2.2% (n = 3285); IV, 4.3% (n = 818); and V and VI, 8.6% (n = 290). From the test data set (n = 7223), we developed 3 risk models (30-day mortality, 90-day mortality, and 90-day and in-hospital mortality) with 11 variables, including age category, RACHS-1 category, preoperative risk factors, number of surgical procedures, unplanned reoperations, status of surgery, surgery type, asplenia, and prematurity (<35 weeks). For the performance metrics of the risk models, C statistic values of 30-day, 90-day, and 90-day and in-hospital mortalities for the test data set were 0.85, 0.85, and 0.84, respectively. When only the RACHS-1 score was used for discrimination, the C statistic values of 30-day, 90-day, and 90-day and in-hospital mortalities for the validation data set were 0.73, 0.73, and 0.77, respectively.

Conclusions The proposed risk scores and categories have high discrimination power for predicting mortality, demonstrating improvement relative to existing consensus-based methods. Risk models incorporating these measures may be useful for comparing mortality outcomes cross institutions or countries with mixed cases.

Original languageEnglish
Pages (from-to)2201-2206
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume148
Issue number5
DOIs
Publication statusPublished - 2014 Nov 1
Externally publishedYes

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Thoracic Surgery
Databases
Mortality
Japan
Hospital Mortality
Risk Adjustment
Reoperation
Logistic Models
Datasets

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Predictors of 90-day mortality after congenital heart surgery : The first report of risk models from a Japanese database. / Miyata, Hiroaki; Murakami, Arata; Tomotaki, Ai; Takaoka, Tetsuhiro; Konuma, Takeshi; Matsumura, Goki; Sano, Syunji; Takamoto, Shinichi.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 148, No. 5, 01.11.2014, p. 2201-2206.

Research output: Contribution to journalArticle

Miyata, Hiroaki ; Murakami, Arata ; Tomotaki, Ai ; Takaoka, Tetsuhiro ; Konuma, Takeshi ; Matsumura, Goki ; Sano, Syunji ; Takamoto, Shinichi. / Predictors of 90-day mortality after congenital heart surgery : The first report of risk models from a Japanese database. In: Journal of Thoracic and Cardiovascular Surgery. 2014 ; Vol. 148, No. 5. pp. 2201-2206.
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AU - Takaoka, Tetsuhiro

AU - Konuma, Takeshi

AU - Matsumura, Goki

AU - Sano, Syunji

AU - Takamoto, Shinichi

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N2 - Objective The purpose of this study was to develop risk models for congenital heart surgery short-term and midterm outcomes from a nationwide integrated database drawn from hospitals in Japan.Methods The Japan Congenital Cardiovascular Surgery Database collects clinical information from institutions throughout Japan specializing in congenital heart surgery. Variables and definitions used in the Japan Congenital Cardiovascular Surgery Database are almost identical to those of the Society of Thoracic Surgeons-European Association for Cardiothoracic Surgery database for congenital heart surgery. We used logistic regression to develop risk models, which were then validated through spilt-sample validation. In addition to procedural complexity categories by Risk Adjustment in Congenital Heart Surgery (RACHS-1) score, we incorporated patient characteristics to predict surgical outcome.Results Among 8923 congenital heart operations performed at 69 sites with cardiac surgical programs, 30-day mortalities by RACHS-1 category were as follows: I, 0.1% (n = 1319); II, 0.5% (n = 3211); III, 2.2% (n = 3285); IV, 4.3% (n = 818); and V and VI, 8.6% (n = 290). From the test data set (n = 7223), we developed 3 risk models (30-day mortality, 90-day mortality, and 90-day and in-hospital mortality) with 11 variables, including age category, RACHS-1 category, preoperative risk factors, number of surgical procedures, unplanned reoperations, status of surgery, surgery type, asplenia, and prematurity (<35 weeks). For the performance metrics of the risk models, C statistic values of 30-day, 90-day, and 90-day and in-hospital mortalities for the test data set were 0.85, 0.85, and 0.84, respectively. When only the RACHS-1 score was used for discrimination, the C statistic values of 30-day, 90-day, and 90-day and in-hospital mortalities for the validation data set were 0.73, 0.73, and 0.77, respectively.Conclusions The proposed risk scores and categories have high discrimination power for predicting mortality, demonstrating improvement relative to existing consensus-based methods. Risk models incorporating these measures may be useful for comparing mortality outcomes cross institutions or countries with mixed cases.

AB - Objective The purpose of this study was to develop risk models for congenital heart surgery short-term and midterm outcomes from a nationwide integrated database drawn from hospitals in Japan.Methods The Japan Congenital Cardiovascular Surgery Database collects clinical information from institutions throughout Japan specializing in congenital heart surgery. Variables and definitions used in the Japan Congenital Cardiovascular Surgery Database are almost identical to those of the Society of Thoracic Surgeons-European Association for Cardiothoracic Surgery database for congenital heart surgery. We used logistic regression to develop risk models, which were then validated through spilt-sample validation. In addition to procedural complexity categories by Risk Adjustment in Congenital Heart Surgery (RACHS-1) score, we incorporated patient characteristics to predict surgical outcome.Results Among 8923 congenital heart operations performed at 69 sites with cardiac surgical programs, 30-day mortalities by RACHS-1 category were as follows: I, 0.1% (n = 1319); II, 0.5% (n = 3211); III, 2.2% (n = 3285); IV, 4.3% (n = 818); and V and VI, 8.6% (n = 290). From the test data set (n = 7223), we developed 3 risk models (30-day mortality, 90-day mortality, and 90-day and in-hospital mortality) with 11 variables, including age category, RACHS-1 category, preoperative risk factors, number of surgical procedures, unplanned reoperations, status of surgery, surgery type, asplenia, and prematurity (<35 weeks). For the performance metrics of the risk models, C statistic values of 30-day, 90-day, and 90-day and in-hospital mortalities for the test data set were 0.85, 0.85, and 0.84, respectively. When only the RACHS-1 score was used for discrimination, the C statistic values of 30-day, 90-day, and 90-day and in-hospital mortalities for the validation data set were 0.73, 0.73, and 0.77, respectively.Conclusions The proposed risk scores and categories have high discrimination power for predicting mortality, demonstrating improvement relative to existing consensus-based methods. Risk models incorporating these measures may be useful for comparing mortality outcomes cross institutions or countries with mixed cases.

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