Abstract
RESULTS: Ten gastric neoplasia cases (gastric cancer and adenoma) were found to be included. Multiple logistic regression analyses identified H. pylori antibody titer ≥3 U/ml (odds ratio=14.4, 95% confidence interval=2.7-76.9; p<0.01) and pepsinogen-I/II ratio ≤4.3 ng/ml (odds ratio=10.0, 95% confidence interval=2.1-47.9; p<0.01), but not age as independent predictive factors of neoplasia.
CONCLUSION: Endoscopy should be considered in individuals with H. pylori antibody titer of ≥3 U/ml and a pepsinogen-I/II ratio of ≤4.3 in those classed as group A by ABC method.
BACKGROUND/AIM: Individuals negative for Helicbacter pylori antibody and with a normal pepsinogen test (group A) are regarded as being at low risk in serum gastric cancer screening known as the ABC method, and endoscopy is not recommended; however, this group may include 2-10% of gastric cancer cases.
PATIENTS AND METHODS: A total of 345 individuals who underwent upper gastrointestinal endoscopy and were classified by ABC as group A (H. pylori antibody titer <10 U/ml, and pepsinogen-I >70 ng/ml or I/II ratio >3) were enrolled, and predictors of gastric neoplasia were investigated.
| Original language | English |
|---|---|
| Pages (from-to) | 6765-6771 |
| Number of pages | 7 |
| Journal | Anticancer Research |
| Volume | 35 |
| Issue number | 12 |
| Publication status | Published - 2015 Dec 1 |
| Externally published | Yes |
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Keywords
- ABC method
- Gastric cancer
- Helicobacter pylori
- pepsinogen
- screening
ASJC Scopus subject areas
- Medicine(all)
Cite this
Predictors of Gastric Neoplasia in Cases Negative for Helicobacter pylori Antibody and with Normal Pepsinogen. / Kishikawa, Hiroshi; Hukuhara, Kayoko; Ito, Asako; Arahata, Kyoko; Takarabe, Sakiko; Kaida, Shogo; Miyauchi, Jun; Miura, Soichiro; Nishida, Jiro.
In: Anticancer Research, Vol. 35, No. 12, 01.12.2015, p. 6765-6771.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictors of Gastric Neoplasia in Cases Negative for Helicobacter pylori Antibody and with Normal Pepsinogen
AU - Kishikawa, Hiroshi
AU - Hukuhara, Kayoko
AU - Ito, Asako
AU - Arahata, Kyoko
AU - Takarabe, Sakiko
AU - Kaida, Shogo
AU - Miyauchi, Jun
AU - Miura, Soichiro
AU - Nishida, Jiro
PY - 2015/12/1
Y1 - 2015/12/1
N2 - RESULTS: Ten gastric neoplasia cases (gastric cancer and adenoma) were found to be included. Multiple logistic regression analyses identified H. pylori antibody titer ≥3 U/ml (odds ratio=14.4, 95% confidence interval=2.7-76.9; p<0.01) and pepsinogen-I/II ratio ≤4.3 ng/ml (odds ratio=10.0, 95% confidence interval=2.1-47.9; p<0.01), but not age as independent predictive factors of neoplasia.CONCLUSION: Endoscopy should be considered in individuals with H. pylori antibody titer of ≥3 U/ml and a pepsinogen-I/II ratio of ≤4.3 in those classed as group A by ABC method.BACKGROUND/AIM: Individuals negative for Helicbacter pylori antibody and with a normal pepsinogen test (group A) are regarded as being at low risk in serum gastric cancer screening known as the ABC method, and endoscopy is not recommended; however, this group may include 2-10% of gastric cancer cases.PATIENTS AND METHODS: A total of 345 individuals who underwent upper gastrointestinal endoscopy and were classified by ABC as group A (H. pylori antibody titer <10 U/ml, and pepsinogen-I >70 ng/ml or I/II ratio >3) were enrolled, and predictors of gastric neoplasia were investigated.
AB - RESULTS: Ten gastric neoplasia cases (gastric cancer and adenoma) were found to be included. Multiple logistic regression analyses identified H. pylori antibody titer ≥3 U/ml (odds ratio=14.4, 95% confidence interval=2.7-76.9; p<0.01) and pepsinogen-I/II ratio ≤4.3 ng/ml (odds ratio=10.0, 95% confidence interval=2.1-47.9; p<0.01), but not age as independent predictive factors of neoplasia.CONCLUSION: Endoscopy should be considered in individuals with H. pylori antibody titer of ≥3 U/ml and a pepsinogen-I/II ratio of ≤4.3 in those classed as group A by ABC method.BACKGROUND/AIM: Individuals negative for Helicbacter pylori antibody and with a normal pepsinogen test (group A) are regarded as being at low risk in serum gastric cancer screening known as the ABC method, and endoscopy is not recommended; however, this group may include 2-10% of gastric cancer cases.PATIENTS AND METHODS: A total of 345 individuals who underwent upper gastrointestinal endoscopy and were classified by ABC as group A (H. pylori antibody titer <10 U/ml, and pepsinogen-I >70 ng/ml or I/II ratio >3) were enrolled, and predictors of gastric neoplasia were investigated.
KW - ABC method
KW - Gastric cancer
KW - Helicobacter pylori
KW - pepsinogen
KW - screening
UR - http://www.scopus.com/inward/record.url?scp=84973408071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973408071&partnerID=8YFLogxK
M3 - Article
C2 - 26637894
AN - SCOPUS:84973408071
VL - 35
SP - 6765
EP - 6771
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 12
ER -