Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer

Yusuke Takahashi; Noriyuki Matsutani; Shigeki Morita; Hitoshi Dejima; Takashi Nakayama; Hirofumi Uehara; Masafumi Kawamura

doi:10.1111/resp.12904

Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer

Yusuke Takahashi, Noriyuki Matsutani, Shigeki Morita, Hitoshi Dejima, Takashi Nakayama, Hirofumi Uehara, Masafumi Kawamura

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Background and objective: Long-term pulmonary function which might include compensatory response (CR) significantly influences quality of life of long-term survivor after major lung resection. We investigated long-term pulmonary function after major lung resection. Methods: A total of 137 patients who had undergone lobar resection for non-small cell lung cancer (NSCLC) from May 2013 to June 2014 had spirometry at 10–14 months after surgery. Actual post-operative forced expiratory volume in 1 s (FEV₁) (FEV_1apo)/predicted post-operative FEV₁ (FEV_1ppo), actual post-operative forced vital capacity (FVC) (FVC_apo)/predicted post-operative FVC (FVC_ppo), its relationship with clinicopathological factors and immunohistochemistry for pro-surfactant protein C (pro-SPC), thyroid transcription factor-1 (TTF-1) and vascular endothelial growth factor receptor 2 (VEGFR2) were investigated. Results: FEV_1apo/FEV_1ppo showed strong correlation with FVC_apo/FVC_ppo (r = 0.628; P < 0.001). We defined greater CR as both FEV_1apo/FEV_1ppo and FVC_apo/FVC_ppo were >120%. Greater CR was significantly associated with decreased smoking index (P < 0.001) and greater resected subsegments (P = 0.037). The never-smoker group revealed significantly greater CR compared with the smoker group in both FEV_1apo/FEV_1ppo (119.9 ± 12.5% vs 107.5 ± 14.2%; P = 0.030) and FVC_apo/FVC_ppo (117.9 ± 9.98% vs 107.2 ± 13.1%; P = 0.046) in case-matched comparison. The expression of pro-SPC, TTF-1 and VEGFR2 in the normal lung parenchyma of greater CR group was significantly higher than those of lesser CR group (P < 0.001 for each). In addition, pro-SPC, TTF-1 and VEGFR2 expressions showed a significant correlation to the degree of CR especially in the smoker group (r = 0.631, 0.705 and 0.732, respectively; P < 0.001 for each). Conclusion: Our data suggest that smokers may develop lesser long-term CR after major lung resection. Decreased expression of pro-SPC, TTF-1 and VEGFR2 may indicate decreased capacity of CR, especially in patients who smoke.

Original language	English
Pages (from-to)	364-371
Number of pages	8
Journal	Respirology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1111/resp.12904
Publication status	Published - 2017 Feb 1
Externally published	Yes

Keywords

airway epithelium
lung cancer
respiratory function tests
thoracic surgery

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/resp.12904

Cite this

@article{dac74b6c06264dfbaecef191d07a5103,

title = "Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer",

abstract = "Background and objective: Long-term pulmonary function which might include compensatory response (CR) significantly influences quality of life of long-term survivor after major lung resection. We investigated long-term pulmonary function after major lung resection. Methods: A total of 137 patients who had undergone lobar resection for non-small cell lung cancer (NSCLC) from May 2013 to June 2014 had spirometry at 10–14 months after surgery. Actual post-operative forced expiratory volume in 1 s (FEV1) (FEV1apo)/predicted post-operative FEV1 (FEV1ppo), actual post-operative forced vital capacity (FVC) (FVCapo)/predicted post-operative FVC (FVCppo), its relationship with clinicopathological factors and immunohistochemistry for pro-surfactant protein C (pro-SPC), thyroid transcription factor-1 (TTF-1) and vascular endothelial growth factor receptor 2 (VEGFR2) were investigated. Results: FEV1apo/FEV1ppo showed strong correlation with FVCapo/FVCppo (r = 0.628; P < 0.001). We defined greater CR as both FEV1apo/FEV1ppo and FVCapo/FVCppo were >120%. Greater CR was significantly associated with decreased smoking index (P < 0.001) and greater resected subsegments (P = 0.037). The never-smoker group revealed significantly greater CR compared with the smoker group in both FEV1apo/FEV1ppo (119.9 ± 12.5% vs 107.5 ± 14.2%; P = 0.030) and FVCapo/FVCppo (117.9 ± 9.98% vs 107.2 ± 13.1%; P = 0.046) in case-matched comparison. The expression of pro-SPC, TTF-1 and VEGFR2 in the normal lung parenchyma of greater CR group was significantly higher than those of lesser CR group (P < 0.001 for each). In addition, pro-SPC, TTF-1 and VEGFR2 expressions showed a significant correlation to the degree of CR especially in the smoker group (r = 0.631, 0.705 and 0.732, respectively; P < 0.001 for each). Conclusion: Our data suggest that smokers may develop lesser long-term CR after major lung resection. Decreased expression of pro-SPC, TTF-1 and VEGFR2 may indicate decreased capacity of CR, especially in patients who smoke.",

keywords = "airway epithelium, lung cancer, respiratory function tests, thoracic surgery",

author = "Yusuke Takahashi and Noriyuki Matsutani and Shigeki Morita and Hitoshi Dejima and Takashi Nakayama and Hirofumi Uehara and Masafumi Kawamura",

note = "Funding Information: We thank to Dr Boris Hristov, Department of General Surgery, Brookdale University Hospital and Medical Center, NY, USA, for editing this manuscript. This study was partly supported by JSPS KAKENHI Grant Number 26462137. Publisher Copyright: {\textcopyright} 2016 Asian Pacific Society of Respirology",

year = "2017",

month = feb,

day = "1",

doi = "10.1111/resp.12904",

language = "English",

volume = "22",

pages = "364--371",

journal = "Respirology",

issn = "1323-7799",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer

AU - Takahashi, Yusuke

AU - Matsutani, Noriyuki

AU - Morita, Shigeki

AU - Dejima, Hitoshi

AU - Nakayama, Takashi

AU - Uehara, Hirofumi

AU - Kawamura, Masafumi

N1 - Funding Information: We thank to Dr Boris Hristov, Department of General Surgery, Brookdale University Hospital and Medical Center, NY, USA, for editing this manuscript. This study was partly supported by JSPS KAKENHI Grant Number 26462137. Publisher Copyright: © 2016 Asian Pacific Society of Respirology

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Background and objective: Long-term pulmonary function which might include compensatory response (CR) significantly influences quality of life of long-term survivor after major lung resection. We investigated long-term pulmonary function after major lung resection. Methods: A total of 137 patients who had undergone lobar resection for non-small cell lung cancer (NSCLC) from May 2013 to June 2014 had spirometry at 10–14 months after surgery. Actual post-operative forced expiratory volume in 1 s (FEV1) (FEV1apo)/predicted post-operative FEV1 (FEV1ppo), actual post-operative forced vital capacity (FVC) (FVCapo)/predicted post-operative FVC (FVCppo), its relationship with clinicopathological factors and immunohistochemistry for pro-surfactant protein C (pro-SPC), thyroid transcription factor-1 (TTF-1) and vascular endothelial growth factor receptor 2 (VEGFR2) were investigated. Results: FEV1apo/FEV1ppo showed strong correlation with FVCapo/FVCppo (r = 0.628; P < 0.001). We defined greater CR as both FEV1apo/FEV1ppo and FVCapo/FVCppo were >120%. Greater CR was significantly associated with decreased smoking index (P < 0.001) and greater resected subsegments (P = 0.037). The never-smoker group revealed significantly greater CR compared with the smoker group in both FEV1apo/FEV1ppo (119.9 ± 12.5% vs 107.5 ± 14.2%; P = 0.030) and FVCapo/FVCppo (117.9 ± 9.98% vs 107.2 ± 13.1%; P = 0.046) in case-matched comparison. The expression of pro-SPC, TTF-1 and VEGFR2 in the normal lung parenchyma of greater CR group was significantly higher than those of lesser CR group (P < 0.001 for each). In addition, pro-SPC, TTF-1 and VEGFR2 expressions showed a significant correlation to the degree of CR especially in the smoker group (r = 0.631, 0.705 and 0.732, respectively; P < 0.001 for each). Conclusion: Our data suggest that smokers may develop lesser long-term CR after major lung resection. Decreased expression of pro-SPC, TTF-1 and VEGFR2 may indicate decreased capacity of CR, especially in patients who smoke.

AB - Background and objective: Long-term pulmonary function which might include compensatory response (CR) significantly influences quality of life of long-term survivor after major lung resection. We investigated long-term pulmonary function after major lung resection. Methods: A total of 137 patients who had undergone lobar resection for non-small cell lung cancer (NSCLC) from May 2013 to June 2014 had spirometry at 10–14 months after surgery. Actual post-operative forced expiratory volume in 1 s (FEV1) (FEV1apo)/predicted post-operative FEV1 (FEV1ppo), actual post-operative forced vital capacity (FVC) (FVCapo)/predicted post-operative FVC (FVCppo), its relationship with clinicopathological factors and immunohistochemistry for pro-surfactant protein C (pro-SPC), thyroid transcription factor-1 (TTF-1) and vascular endothelial growth factor receptor 2 (VEGFR2) were investigated. Results: FEV1apo/FEV1ppo showed strong correlation with FVCapo/FVCppo (r = 0.628; P < 0.001). We defined greater CR as both FEV1apo/FEV1ppo and FVCapo/FVCppo were >120%. Greater CR was significantly associated with decreased smoking index (P < 0.001) and greater resected subsegments (P = 0.037). The never-smoker group revealed significantly greater CR compared with the smoker group in both FEV1apo/FEV1ppo (119.9 ± 12.5% vs 107.5 ± 14.2%; P = 0.030) and FVCapo/FVCppo (117.9 ± 9.98% vs 107.2 ± 13.1%; P = 0.046) in case-matched comparison. The expression of pro-SPC, TTF-1 and VEGFR2 in the normal lung parenchyma of greater CR group was significantly higher than those of lesser CR group (P < 0.001 for each). In addition, pro-SPC, TTF-1 and VEGFR2 expressions showed a significant correlation to the degree of CR especially in the smoker group (r = 0.631, 0.705 and 0.732, respectively; P < 0.001 for each). Conclusion: Our data suggest that smokers may develop lesser long-term CR after major lung resection. Decreased expression of pro-SPC, TTF-1 and VEGFR2 may indicate decreased capacity of CR, especially in patients who smoke.

KW - airway epithelium

KW - lung cancer

KW - respiratory function tests

KW - thoracic surgery

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U2 - 10.1111/resp.12904

DO - 10.1111/resp.12904

M3 - Article

C2 - 27649690

AN - SCOPUS:84988431483

SN - 1323-7799

VL - 22

SP - 364

EP - 371

JO - Respirology

JF - Respirology

IS - 2

ER -

Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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