Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer

Yusuke Takahashi, Noriyuki Matsutani, Shigeki Morita, Hitoshi Dejima, Takashi Nakayama, Hirofumi Uehara, Masafumi Kawamura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and objective: Long-term pulmonary function which might include compensatory response (CR) significantly influences quality of life of long-term survivor after major lung resection. We investigated long-term pulmonary function after major lung resection. Methods: A total of 137 patients who had undergone lobar resection for non-small cell lung cancer (NSCLC) from May 2013 to June 2014 had spirometry at 10–14 months after surgery. Actual post-operative forced expiratory volume in 1 s (FEV1) (FEV1apo)/predicted post-operative FEV1 (FEV1ppo), actual post-operative forced vital capacity (FVC) (FVCapo)/predicted post-operative FVC (FVCppo), its relationship with clinicopathological factors and immunohistochemistry for pro-surfactant protein C (pro-SPC), thyroid transcription factor-1 (TTF-1) and vascular endothelial growth factor receptor 2 (VEGFR2) were investigated. Results: FEV1apo/FEV1ppo showed strong correlation with FVCapo/FVCppo (r = 0.628; P < 0.001). We defined greater CR as both FEV1apo/FEV1ppo and FVCapo/FVCppo were >120%. Greater CR was significantly associated with decreased smoking index (P < 0.001) and greater resected subsegments (P = 0.037). The never-smoker group revealed significantly greater CR compared with the smoker group in both FEV1apo/FEV1ppo (119.9 ± 12.5% vs 107.5 ± 14.2%; P = 0.030) and FVCapo/FVCppo (117.9 ± 9.98% vs 107.2 ± 13.1%; P = 0.046) in case-matched comparison. The expression of pro-SPC, TTF-1 and VEGFR2 in the normal lung parenchyma of greater CR group was significantly higher than those of lesser CR group (P < 0.001 for each). In addition, pro-SPC, TTF-1 and VEGFR2 expressions showed a significant correlation to the degree of CR especially in the smoker group (r = 0.631, 0.705 and 0.732, respectively; P < 0.001 for each). Conclusion: Our data suggest that smokers may develop lesser long-term CR after major lung resection. Decreased expression of pro-SPC, TTF-1 and VEGFR2 may indicate decreased capacity of CR, especially in patients who smoke.

Original languageEnglish
Pages (from-to)364-371
Number of pages8
JournalRespirology
Volume22
Issue number2
DOIs
Publication statusPublished - 2017 Feb 1
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor Receptor-2
Protein C
Surface-Active Agents
Lung
Vital Capacity
Forced Expiratory Volume
Spirometry
Smoke
Survivors
Smoking
Immunohistochemistry
Quality of Life
thyroid nuclear factor 1

Keywords

  • airway epithelium
  • lung cancer
  • respiratory function tests
  • thoracic surgery

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Takahashi, Y., Matsutani, N., Morita, S., Dejima, H., Nakayama, T., Uehara, H., & Kawamura, M. (2017). Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer. Respirology, 22(2), 364-371. https://doi.org/10.1111/resp.12904

Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer. / Takahashi, Yusuke; Matsutani, Noriyuki; Morita, Shigeki; Dejima, Hitoshi; Nakayama, Takashi; Uehara, Hirofumi; Kawamura, Masafumi.

In: Respirology, Vol. 22, No. 2, 01.02.2017, p. 364-371.

Research output: Contribution to journalArticle

Takahashi, Y, Matsutani, N, Morita, S, Dejima, H, Nakayama, T, Uehara, H & Kawamura, M 2017, 'Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer', Respirology, vol. 22, no. 2, pp. 364-371. https://doi.org/10.1111/resp.12904
Takahashi, Yusuke ; Matsutani, Noriyuki ; Morita, Shigeki ; Dejima, Hitoshi ; Nakayama, Takashi ; Uehara, Hirofumi ; Kawamura, Masafumi. / Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer. In: Respirology. 2017 ; Vol. 22, No. 2. pp. 364-371.
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abstract = "Background and objective: Long-term pulmonary function which might include compensatory response (CR) significantly influences quality of life of long-term survivor after major lung resection. We investigated long-term pulmonary function after major lung resection. Methods: A total of 137 patients who had undergone lobar resection for non-small cell lung cancer (NSCLC) from May 2013 to June 2014 had spirometry at 10–14 months after surgery. Actual post-operative forced expiratory volume in 1 s (FEV1) (FEV1apo)/predicted post-operative FEV1 (FEV1ppo), actual post-operative forced vital capacity (FVC) (FVCapo)/predicted post-operative FVC (FVCppo), its relationship with clinicopathological factors and immunohistochemistry for pro-surfactant protein C (pro-SPC), thyroid transcription factor-1 (TTF-1) and vascular endothelial growth factor receptor 2 (VEGFR2) were investigated. Results: FEV1apo/FEV1ppo showed strong correlation with FVCapo/FVCppo (r = 0.628; P < 0.001). We defined greater CR as both FEV1apo/FEV1ppo and FVCapo/FVCppo were >120{\%}. Greater CR was significantly associated with decreased smoking index (P < 0.001) and greater resected subsegments (P = 0.037). The never-smoker group revealed significantly greater CR compared with the smoker group in both FEV1apo/FEV1ppo (119.9 ± 12.5{\%} vs 107.5 ± 14.2{\%}; P = 0.030) and FVCapo/FVCppo (117.9 ± 9.98{\%} vs 107.2 ± 13.1{\%}; P = 0.046) in case-matched comparison. The expression of pro-SPC, TTF-1 and VEGFR2 in the normal lung parenchyma of greater CR group was significantly higher than those of lesser CR group (P < 0.001 for each). In addition, pro-SPC, TTF-1 and VEGFR2 expressions showed a significant correlation to the degree of CR especially in the smoker group (r = 0.631, 0.705 and 0.732, respectively; P < 0.001 for each). Conclusion: Our data suggest that smokers may develop lesser long-term CR after major lung resection. Decreased expression of pro-SPC, TTF-1 and VEGFR2 may indicate decreased capacity of CR, especially in patients who smoke.",
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AU - Dejima, Hitoshi

AU - Nakayama, Takashi

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N2 - Background and objective: Long-term pulmonary function which might include compensatory response (CR) significantly influences quality of life of long-term survivor after major lung resection. We investigated long-term pulmonary function after major lung resection. Methods: A total of 137 patients who had undergone lobar resection for non-small cell lung cancer (NSCLC) from May 2013 to June 2014 had spirometry at 10–14 months after surgery. Actual post-operative forced expiratory volume in 1 s (FEV1) (FEV1apo)/predicted post-operative FEV1 (FEV1ppo), actual post-operative forced vital capacity (FVC) (FVCapo)/predicted post-operative FVC (FVCppo), its relationship with clinicopathological factors and immunohistochemistry for pro-surfactant protein C (pro-SPC), thyroid transcription factor-1 (TTF-1) and vascular endothelial growth factor receptor 2 (VEGFR2) were investigated. Results: FEV1apo/FEV1ppo showed strong correlation with FVCapo/FVCppo (r = 0.628; P < 0.001). We defined greater CR as both FEV1apo/FEV1ppo and FVCapo/FVCppo were >120%. Greater CR was significantly associated with decreased smoking index (P < 0.001) and greater resected subsegments (P = 0.037). The never-smoker group revealed significantly greater CR compared with the smoker group in both FEV1apo/FEV1ppo (119.9 ± 12.5% vs 107.5 ± 14.2%; P = 0.030) and FVCapo/FVCppo (117.9 ± 9.98% vs 107.2 ± 13.1%; P = 0.046) in case-matched comparison. The expression of pro-SPC, TTF-1 and VEGFR2 in the normal lung parenchyma of greater CR group was significantly higher than those of lesser CR group (P < 0.001 for each). In addition, pro-SPC, TTF-1 and VEGFR2 expressions showed a significant correlation to the degree of CR especially in the smoker group (r = 0.631, 0.705 and 0.732, respectively; P < 0.001 for each). Conclusion: Our data suggest that smokers may develop lesser long-term CR after major lung resection. Decreased expression of pro-SPC, TTF-1 and VEGFR2 may indicate decreased capacity of CR, especially in patients who smoke.

AB - Background and objective: Long-term pulmonary function which might include compensatory response (CR) significantly influences quality of life of long-term survivor after major lung resection. We investigated long-term pulmonary function after major lung resection. Methods: A total of 137 patients who had undergone lobar resection for non-small cell lung cancer (NSCLC) from May 2013 to June 2014 had spirometry at 10–14 months after surgery. Actual post-operative forced expiratory volume in 1 s (FEV1) (FEV1apo)/predicted post-operative FEV1 (FEV1ppo), actual post-operative forced vital capacity (FVC) (FVCapo)/predicted post-operative FVC (FVCppo), its relationship with clinicopathological factors and immunohistochemistry for pro-surfactant protein C (pro-SPC), thyroid transcription factor-1 (TTF-1) and vascular endothelial growth factor receptor 2 (VEGFR2) were investigated. Results: FEV1apo/FEV1ppo showed strong correlation with FVCapo/FVCppo (r = 0.628; P < 0.001). We defined greater CR as both FEV1apo/FEV1ppo and FVCapo/FVCppo were >120%. Greater CR was significantly associated with decreased smoking index (P < 0.001) and greater resected subsegments (P = 0.037). The never-smoker group revealed significantly greater CR compared with the smoker group in both FEV1apo/FEV1ppo (119.9 ± 12.5% vs 107.5 ± 14.2%; P = 0.030) and FVCapo/FVCppo (117.9 ± 9.98% vs 107.2 ± 13.1%; P = 0.046) in case-matched comparison. The expression of pro-SPC, TTF-1 and VEGFR2 in the normal lung parenchyma of greater CR group was significantly higher than those of lesser CR group (P < 0.001 for each). In addition, pro-SPC, TTF-1 and VEGFR2 expressions showed a significant correlation to the degree of CR especially in the smoker group (r = 0.631, 0.705 and 0.732, respectively; P < 0.001 for each). Conclusion: Our data suggest that smokers may develop lesser long-term CR after major lung resection. Decreased expression of pro-SPC, TTF-1 and VEGFR2 may indicate decreased capacity of CR, especially in patients who smoke.

KW - airway epithelium

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