Predictors of primary lung cancer in a solitary pulmonary lesion after a previous malignancy

Akie Nakadate, Masashi Nakadate, Yasunori Sato, Tassei Nakagawa, Katsuya Yoshida, Yoshio Suzuki, Yukihiro Yoshida

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: A solitary pulmonary lesion in patients with a history of malignancy may be either primary lung cancer or a metastatic lung tumor or benign nodule. We retrospectively examined the preoperative predictive factors for determining the type of pathology. Methods: We used an exact logistic regression analysis to identify radiological and clinical predictors of primary lung cancer. The study included 187 patients who underwent pulmonary resection for a solitary pulmonary lesion and had received previous treatment for a malignancy. Results: There were 107 patients with primary lung cancer, 74 with metastatic lung tumors, and 6 with benign lesions. The previous malignancy included colorectal cancer in 71 patients. A disease-free interval exceeding 5 years and ground-glass opacity were found in 27.0% (20/74) and 1.4% (1/74) of metastatic lung tumors, respectively. Multivariate logistic regression analysis demonstrated that spiculation [adjusted odds ratio (a-OR), 1.74; 95% confidence interval (CI), 1.09–2.86], pleural indentation (a-OR 1.99, 95% CI 1.24–3.29), and ground-glass opacity (a-OR 5.28, 95% CI 2.61–13.1) on high-resolution computed tomography, maximum standardized uptake value (a-OR 1.14, 95% CI 1.02–1.29), current and former smokers (a-OR 1.96, 95% CI 1.21–3.30), and previous malignancy other than colorectal cancer (a-OR 2.02, 95% CI 1.26–3.37) were associated with primary lung cancer. Conclusions: A combination of radiological findings, smoking history, and type of previous malignancy can improve the ability to predict primary lung cancer in the presence of a solitary pulmonary lesion that appears after previous treatment for a malignancy.

Original languageEnglish
Pages (from-to)698-704
Number of pages7
JournalGeneral thoracic and cardiovascular surgery
Volume65
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1
Externally publishedYes

Fingerprint

Lung Neoplasms
Lung
Odds Ratio
Confidence Intervals
Neoplasms
Glass
Colorectal Neoplasms
Logistic Models
Regression Analysis
Aptitude
Smoking
History
Tomography
Pathology
Therapeutics

Keywords

  • Carcinoma, non-small cell lung
  • Positron emission tomography computed tomography
  • Tomography, X-ray computed

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Predictors of primary lung cancer in a solitary pulmonary lesion after a previous malignancy. / Nakadate, Akie; Nakadate, Masashi; Sato, Yasunori; Nakagawa, Tassei; Yoshida, Katsuya; Suzuki, Yoshio; Yoshida, Yukihiro.

In: General thoracic and cardiovascular surgery, Vol. 65, No. 12, 01.12.2017, p. 698-704.

Research output: Contribution to journalArticle

Nakadate, Akie ; Nakadate, Masashi ; Sato, Yasunori ; Nakagawa, Tassei ; Yoshida, Katsuya ; Suzuki, Yoshio ; Yoshida, Yukihiro. / Predictors of primary lung cancer in a solitary pulmonary lesion after a previous malignancy. In: General thoracic and cardiovascular surgery. 2017 ; Vol. 65, No. 12. pp. 698-704.
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abstract = "Objective: A solitary pulmonary lesion in patients with a history of malignancy may be either primary lung cancer or a metastatic lung tumor or benign nodule. We retrospectively examined the preoperative predictive factors for determining the type of pathology. Methods: We used an exact logistic regression analysis to identify radiological and clinical predictors of primary lung cancer. The study included 187 patients who underwent pulmonary resection for a solitary pulmonary lesion and had received previous treatment for a malignancy. Results: There were 107 patients with primary lung cancer, 74 with metastatic lung tumors, and 6 with benign lesions. The previous malignancy included colorectal cancer in 71 patients. A disease-free interval exceeding 5 years and ground-glass opacity were found in 27.0{\%} (20/74) and 1.4{\%} (1/74) of metastatic lung tumors, respectively. Multivariate logistic regression analysis demonstrated that spiculation [adjusted odds ratio (a-OR), 1.74; 95{\%} confidence interval (CI), 1.09–2.86], pleural indentation (a-OR 1.99, 95{\%} CI 1.24–3.29), and ground-glass opacity (a-OR 5.28, 95{\%} CI 2.61–13.1) on high-resolution computed tomography, maximum standardized uptake value (a-OR 1.14, 95{\%} CI 1.02–1.29), current and former smokers (a-OR 1.96, 95{\%} CI 1.21–3.30), and previous malignancy other than colorectal cancer (a-OR 2.02, 95{\%} CI 1.26–3.37) were associated with primary lung cancer. Conclusions: A combination of radiological findings, smoking history, and type of previous malignancy can improve the ability to predict primary lung cancer in the presence of a solitary pulmonary lesion that appears after previous treatment for a malignancy.",
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T1 - Predictors of primary lung cancer in a solitary pulmonary lesion after a previous malignancy

AU - Nakadate, Akie

AU - Nakadate, Masashi

AU - Sato, Yasunori

AU - Nakagawa, Tassei

AU - Yoshida, Katsuya

AU - Suzuki, Yoshio

AU - Yoshida, Yukihiro

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Objective: A solitary pulmonary lesion in patients with a history of malignancy may be either primary lung cancer or a metastatic lung tumor or benign nodule. We retrospectively examined the preoperative predictive factors for determining the type of pathology. Methods: We used an exact logistic regression analysis to identify radiological and clinical predictors of primary lung cancer. The study included 187 patients who underwent pulmonary resection for a solitary pulmonary lesion and had received previous treatment for a malignancy. Results: There were 107 patients with primary lung cancer, 74 with metastatic lung tumors, and 6 with benign lesions. The previous malignancy included colorectal cancer in 71 patients. A disease-free interval exceeding 5 years and ground-glass opacity were found in 27.0% (20/74) and 1.4% (1/74) of metastatic lung tumors, respectively. Multivariate logistic regression analysis demonstrated that spiculation [adjusted odds ratio (a-OR), 1.74; 95% confidence interval (CI), 1.09–2.86], pleural indentation (a-OR 1.99, 95% CI 1.24–3.29), and ground-glass opacity (a-OR 5.28, 95% CI 2.61–13.1) on high-resolution computed tomography, maximum standardized uptake value (a-OR 1.14, 95% CI 1.02–1.29), current and former smokers (a-OR 1.96, 95% CI 1.21–3.30), and previous malignancy other than colorectal cancer (a-OR 2.02, 95% CI 1.26–3.37) were associated with primary lung cancer. Conclusions: A combination of radiological findings, smoking history, and type of previous malignancy can improve the ability to predict primary lung cancer in the presence of a solitary pulmonary lesion that appears after previous treatment for a malignancy.

AB - Objective: A solitary pulmonary lesion in patients with a history of malignancy may be either primary lung cancer or a metastatic lung tumor or benign nodule. We retrospectively examined the preoperative predictive factors for determining the type of pathology. Methods: We used an exact logistic regression analysis to identify radiological and clinical predictors of primary lung cancer. The study included 187 patients who underwent pulmonary resection for a solitary pulmonary lesion and had received previous treatment for a malignancy. Results: There were 107 patients with primary lung cancer, 74 with metastatic lung tumors, and 6 with benign lesions. The previous malignancy included colorectal cancer in 71 patients. A disease-free interval exceeding 5 years and ground-glass opacity were found in 27.0% (20/74) and 1.4% (1/74) of metastatic lung tumors, respectively. Multivariate logistic regression analysis demonstrated that spiculation [adjusted odds ratio (a-OR), 1.74; 95% confidence interval (CI), 1.09–2.86], pleural indentation (a-OR 1.99, 95% CI 1.24–3.29), and ground-glass opacity (a-OR 5.28, 95% CI 2.61–13.1) on high-resolution computed tomography, maximum standardized uptake value (a-OR 1.14, 95% CI 1.02–1.29), current and former smokers (a-OR 1.96, 95% CI 1.21–3.30), and previous malignancy other than colorectal cancer (a-OR 2.02, 95% CI 1.26–3.37) were associated with primary lung cancer. Conclusions: A combination of radiological findings, smoking history, and type of previous malignancy can improve the ability to predict primary lung cancer in the presence of a solitary pulmonary lesion that appears after previous treatment for a malignancy.

KW - Carcinoma, non-small cell lung

KW - Positron emission tomography computed tomography

KW - Tomography, X-ray computed

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