TY - JOUR
T1 - Predictors to assess non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastasis
AU - Jinno, Hiromitsu
AU - Sakata, Michio
AU - Asaga, Sota
AU - Wada, Masahiro
AU - Shimada, Toshiyuki
AU - Kitagawa, Yuko
AU - Suzuki, Takayuki
AU - Nakahara, Tadaki
AU - Kitamura, Naoto
AU - Kubo, Atsushi
AU - Mukai, Makio
AU - Ikeda, Tadashi
AU - Kitajima, Masaki
PY - 2008/11
Y1 - 2008/11
N2 - The next step of sentinel lymph node biopsy (SLNB) in breast cancer is to determine which patients need axillary lymph node dissection (ALND) following a positive SLNB. A prospective database of 239 patients who underwent SLNB followed by complete ALND at Keio University Hospital from January 2001 to June 2005 was reviewed. A total of 131 patients with one or more positive sentinel lymph nodes (SLNs) were further analyzed. A univariate analysis showed a significant correlation between non-SLN involvement and lymphatic invasion, vascular invasion, number of tumor-involved SLNs, radioactivity of SLNs, and size of SLN metastasis (p = 0.0002, p = 0.004, p = 0.006, p = 0.04, p = 0.03, respectively). By multivariate analysis, lymphatic invasion and the number of tumor-involved SLNs remained significant predictors of non-SLN involvement. In breast cancer patients with a positive SLN, lymphatic invasion and the number of tumor-involved SLNs were both independent predictors of non-SLN involvement.
AB - The next step of sentinel lymph node biopsy (SLNB) in breast cancer is to determine which patients need axillary lymph node dissection (ALND) following a positive SLNB. A prospective database of 239 patients who underwent SLNB followed by complete ALND at Keio University Hospital from January 2001 to June 2005 was reviewed. A total of 131 patients with one or more positive sentinel lymph nodes (SLNs) were further analyzed. A univariate analysis showed a significant correlation between non-SLN involvement and lymphatic invasion, vascular invasion, number of tumor-involved SLNs, radioactivity of SLNs, and size of SLN metastasis (p = 0.0002, p = 0.004, p = 0.006, p = 0.04, p = 0.03, respectively). By multivariate analysis, lymphatic invasion and the number of tumor-involved SLNs remained significant predictors of non-SLN involvement. In breast cancer patients with a positive SLN, lymphatic invasion and the number of tumor-involved SLNs were both independent predictors of non-SLN involvement.
KW - Breast cancer
KW - Non-sentinel lymph node metastasis
KW - Sentinel lymph node
UR - http://www.scopus.com/inward/record.url?scp=55649122955&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55649122955&partnerID=8YFLogxK
U2 - 10.1111/j.1524-4741.2008.00646.x
DO - 10.1111/j.1524-4741.2008.00646.x
M3 - Article
C2 - 19000054
AN - SCOPUS:55649122955
SN - 1075-122X
VL - 14
SP - 551
EP - 555
JO - Breast Journal
JF - Breast Journal
IS - 6
ER -
