Preferential activation of the complement system in the lower epidermis of patients with pemphigus vulgaris

J. C. Lapiere, J. Guitart, D. A. Ettlin, D. M. Chen, Masayuki Amagai, L. S. Chan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Pemphigus vulgaris (PV) is an immune-mediated blistering skin disease characterized by acantholysis of the suprabasal epidermis and by IgG autoantibodies targeting a desmosomal component, desmoglein 3. IgG alone has been demonstrated to induce acantholysis in some experimental conditions. The role of the complement system in blister formation in PV remains controversial. We describe four consecutive patients with new-onset PV. The acantholytic process occurred in the lower epidermis and colocalized with deposition of complement C3 and the membrane attack complex C5b9. The colocalization of complement deposition with the acantholytic process in the lower epidermis supports a role for the complement system in blister formation in PV.

Original languageEnglish
Pages (from-to)851-854
Number of pages4
JournalBritish Journal of Dermatology
Volume139
Issue number5
DOIs
Publication statusPublished - 1998

Fingerprint

Pemphigus
Complement Activation
Epidermis
Acantholysis
Blister
Desmoglein 3
Immunoglobulin G
Complement Membrane Attack Complex
Complement C3
Skin Diseases
Autoantibodies

ASJC Scopus subject areas

  • Dermatology

Cite this

Preferential activation of the complement system in the lower epidermis of patients with pemphigus vulgaris. / Lapiere, J. C.; Guitart, J.; Ettlin, D. A.; Chen, D. M.; Amagai, Masayuki; Chan, L. S.

In: British Journal of Dermatology, Vol. 139, No. 5, 1998, p. 851-854.

Research output: Contribution to journalArticle

Lapiere, J. C. ; Guitart, J. ; Ettlin, D. A. ; Chen, D. M. ; Amagai, Masayuki ; Chan, L. S. / Preferential activation of the complement system in the lower epidermis of patients with pemphigus vulgaris. In: British Journal of Dermatology. 1998 ; Vol. 139, No. 5. pp. 851-854.
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AU - Amagai, Masayuki

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