Preferential localization of CD8+ α(E)β7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogren's syndrome

Tsutomu Fujihara, Hiromi Fujita, Kazuo Tsubota, Keiko Saito, Kensei Tsuzaka, Tohru Abe, Tsutomu Takeuchi

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The T lymphocytes that infiltrate the exocrine glands in Sjogren's syndrome (SS) play a key role in damaging glandular epithelial cells, but the mechanisms of tiffs damage by T lymphocytes are not fully understood. To determine the cellular basis of this phenomenon, we focused our attention on the T lymphocytes around acinar epithelial cells in SS. We showed that CD8+ but not CD4+ T lymphocytes were located around the acinar epithelial cells and that a majority of these CD8+ T lymphocytes possess an unique integrin, α(E)β7 (CD103). The acinar epithelial cell adherent with α(E)β7 (CD103)+ CD8+ T lymphocytes was apoptotic. Both the perforin/granzyme B and Fas/Fas ligand pathways were implicated in the process of programmed cell death in lacrimal glands. These results suggested that α(E)β7 integrin, by interacting with E-cadherin, mediates the adhesion between CD8+ T lymphocytes and acinar epithelial cells in SS and participates in inducing epithelial cell apoptosis, leading to secretory dysfunction of exocrine glands, a hallmark of SS.

Original languageEnglish
Pages (from-to)2226-2235
Number of pages10
JournalJournal of Immunology
Volume163
Issue number4
Publication statusPublished - 1999 Aug 15
Externally publishedYes

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Acinar Cells
Sjogren's Syndrome
Epithelial Cells
Apoptosis
T-Lymphocytes
Exocrine Glands
Integrins
Lacrimal Apparatus
Fas Ligand Protein
Tocopherols
Cadherins
Cell Death

ASJC Scopus subject areas

  • Immunology

Cite this

Preferential localization of CD8+ α(E)β7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogren's syndrome. / Fujihara, Tsutomu; Fujita, Hiromi; Tsubota, Kazuo; Saito, Keiko; Tsuzaka, Kensei; Abe, Tohru; Takeuchi, Tsutomu.

In: Journal of Immunology, Vol. 163, No. 4, 15.08.1999, p. 2226-2235.

Research output: Contribution to journalArticle

Fujihara, Tsutomu ; Fujita, Hiromi ; Tsubota, Kazuo ; Saito, Keiko ; Tsuzaka, Kensei ; Abe, Tohru ; Takeuchi, Tsutomu. / Preferential localization of CD8+ α(E)β7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogren's syndrome. In: Journal of Immunology. 1999 ; Vol. 163, No. 4. pp. 2226-2235.
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