Prefrontal cortex mediation of cognitive enhancement in rewarding motivational contexts

Koji Jimura, Hannah S. Locke, Todd S. Braver

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Increasing the reward value of behavioral goals can facilitate cognitive processes required for goal achievement. This facilitation may be accomplished by the dynamic and flexible engagement of cognitive control mechanisms operating in distributed brain regions. It is still not clear, however, what are the characteristics of individuals, situations, and neural activation dynamics that optimize motivation-linked cognitive enhancement. Here we show that highly reward-sensitive individuals exhibited greater improvement of working memory performance in rewarding contexts, but exclusively on trials that were not rewarded. This effect was mediated by a shift in the temporal dynamics of activation within right lateral prefrontal cortex, from a transient to predominantly tonic mode, with an additional anticipatory transient boost. In contexts with intermittent rewards, a strategy of proactive cognitive control may enable globally optimal performance to facilitate reward attainment. Reward-sensitive individuals appear preferentially motivated to adopt this resource-demanding strategy, resulting in paradoxical benefits selectively for nonrewarded events.

Original languageEnglish
Pages (from-to)8871-8876
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number19
DOIs
Publication statusPublished - 2010 May 11

Keywords

  • Dopamine
  • Executive function
  • Mixed blocked/event-related fMRI
  • Personality
  • Working memory

ASJC Scopus subject areas

  • General

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