Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss

Nobuaki Ozawa, Tetsuo Maruyama, Takashi Nagashima, Masanori Ono, Toru Arase, Hitoshi Ishimoto, Yasunori Yoshimura

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Cytogenetic investigation of 2,324 Japanese couples with repeated pregnancy loss revealed that 4.91% of couples (n = 114) had chromosome abnormalities including reciprocal translocation (n = 74), Robertsonian translocation (n = 23), and inversion (n = 10). Parental reciprocal translocation was a significant predictor of subsequent miscarriage (adjusted odds ratio: 3.6, 95% confidence interval: 1.8-7.1), and most of the miscarriages of the carrier couples were inevitable because of abnormal karyotypes, despite appropriate treatments.

Original languageEnglish
Pages (from-to)1301-1304
Number of pages4
JournalFertility and Sterility
Volume90
Issue number4
DOIs
Publication statusPublished - 2008 Oct 1

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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