TY - JOUR
T1 - Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss
AU - Ozawa, Nobuaki
AU - Maruyama, Tetsuo
AU - Nagashima, Takashi
AU - Ono, Masanori
AU - Arase, Toru
AU - Ishimoto, Hitoshi
AU - Yoshimura, Yasunori
PY - 2008/10
Y1 - 2008/10
N2 - Cytogenetic investigation of 2,324 Japanese couples with repeated pregnancy loss revealed that 4.91% of couples (n = 114) had chromosome abnormalities including reciprocal translocation (n = 74), Robertsonian translocation (n = 23), and inversion (n = 10). Parental reciprocal translocation was a significant predictor of subsequent miscarriage (adjusted odds ratio: 3.6, 95% confidence interval: 1.8-7.1), and most of the miscarriages of the carrier couples were inevitable because of abnormal karyotypes, despite appropriate treatments.
AB - Cytogenetic investigation of 2,324 Japanese couples with repeated pregnancy loss revealed that 4.91% of couples (n = 114) had chromosome abnormalities including reciprocal translocation (n = 74), Robertsonian translocation (n = 23), and inversion (n = 10). Parental reciprocal translocation was a significant predictor of subsequent miscarriage (adjusted odds ratio: 3.6, 95% confidence interval: 1.8-7.1), and most of the miscarriages of the carrier couples were inevitable because of abnormal karyotypes, despite appropriate treatments.
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U2 - 10.1016/j.fertnstert.2007.09.051
DO - 10.1016/j.fertnstert.2007.09.051
M3 - Article
C2 - 18166176
AN - SCOPUS:52949095433
SN - 0015-0282
VL - 90
SP - 1301
EP - 1304
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 4
ER -