Preliminary use of insulin-like growth factor-I as a biomarker for sorting high-dose donepezil responders among Japanese patients with Alzheimer's disease

Bun Yamagata, Takuya Watanabe, Hiroi Tomioka, Hitomi Kobayashi, Yasuko Nakano, Masaru Mimura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Treatment with donepezil (maximum dose, 10. mg/day) was recently approved in Japan for severe Alzheimer's disease (AD). We examined the usefulness of serum insulin-like growth factor-I (IGF-I) level as a biomarker for predicting responders to 10. mg/day-donepezil treatment among mild-to-moderate AD patients. The study population consisted of 23 mild-to-moderate AD patients, who were non-responders to 5. mg/day-donepezil treatment. AD patients were divided into responders and non-responders based on changes in mini-mental state examination (MMSE) scores before and 12. weeks after increasing donepezil dose from 5 to 10. mg/day. Before increasing donepezil dose, based on serum IGF-I levels and MMSE scores positively correlated with each other, AD patients were classified into three groups. Group A (n=6) had IGF-I ≤99ng/mL and MMSE ≤18, group B (n=9) had IGF-I ≤99 ng/mL and MMSE >18, and group C (n=8) had IGF-I >99 ng/mL and MMSE > 18. Serum IGF-I levels were significantly lower in groups A and B than group C. After 10. mg/day-donepezil treatment, the mean MMSE improved significantly only in group A. The prevalence of responders to the treatment was markedly greater in group A than in groups B and C. These results suggested that decreased serum IGF-I level combined with low MMSE score may be a useful biomarker for predicting responders to 10. mg/day-donepezil treatment in mild-to-moderate AD patients exhibiting a poor response to 5. mg/day-donepezil treatment.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalRegulatory Peptides
Volume163
Issue number1-3
DOIs
Publication statusPublished - 2010 Aug 1
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Cognitive function
  • Donepezil
  • Insulin-like growth factor-I
  • Responder

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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