Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns

Fumihiro Sugawa, Yuka Wada, Tetsuo Maruyama, Hiroshi Uchida, Bunpei Ishizuka, Tsutomu Ogata

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The CAG repeat lengths weighted by X-inactivation ratios were significantly shorter in 58 Japanese patients with premature ovarian failure (POF) than in 42 age-matched control females with normal menses. The results suggest that short CAG repeats with a relatively high androgen receptor function may constitute a susceptibility factor for the development of POF.

Original languageEnglish
Pages (from-to)649-652
Number of pages4
JournalFertility and Sterility
Volume91
Issue number2
DOIs
Publication statusPublished - 2009 Feb

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Primary Ovarian Insufficiency
X Chromosome Inactivation
Androgen Receptors
Menstruation
Genes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns. / Sugawa, Fumihiro; Wada, Yuka; Maruyama, Tetsuo; Uchida, Hiroshi; Ishizuka, Bunpei; Ogata, Tsutomu.

In: Fertility and Sterility, Vol. 91, No. 2, 02.2009, p. 649-652.

Research output: Contribution to journalArticle

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