Premorbid risk factors for alcohol dependence in antisocial personality disorder

Aihide Yoshino, Taihei Fukuhara, Motoichiro Kato

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Abstract

Background: Many, but not all, types of antisocial personality disorders (ASP) are complicated by alcohol dependence. Therefore, some additional risk factors may exist for alcohol dependence co-occurring with ASP. We studied whether severe childhood conduct disorder and a family history of alcohol dependence are possible risk factors for the development of alcohol dependence in ASP. Methods: The subjects were 81 male Japanese criminals diagnosed with DSM-III-R ASP. Relative risks of alcohol dependence for severe conduct disorder and for a positive family history were estimated by using a multiple logistic model. Results: Forty-three subjects (53.0%) met criteria for DSM-III-R alcohol dependence. The relative risk of alcohol dependence for severe conduct disorder (n = 44), compared with mild conduct disorder, was 4.1; whereas the relative risk for a positive family history (n = 31), relative to a negative family history, was 1.9. Severe childhood conduct disorder was also associated with severe adulthood antisocial behavior and an earlier onset of alcohol dependence. Conclusions: The results suggest that severe childhood conduct disorder and a positive family history of alcohol dependence are independent premorbid risk factors for developing alcohol dependence among persons with ASP.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalAlcoholism: Clinical and Experimental Research
Volume24
Issue number1
DOIs
Publication statusPublished - 2000 Jan

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Keywords

  • Alcohol Dependence
  • Antisocial Personality Disorder
  • Conduct Disorder
  • Family History
  • Predisposing Factors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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