Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

Yoshiro Saikawa, Yoshikiyo Akasaka, Toshio Kanai, Yoshihide Otani, Koichiro Kumai, Tetsuro Kubota, Masaki Kitajima

Research output: Contribution to journalArticle

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Abstract

We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade la effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.

Original languageEnglish
Pages (from-to)381-386
Number of pages6
JournalOncology Reports
Volume10
Issue number2
Publication statusPublished - 2003 Mar

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Combination Drug Therapy
Cisplatin
Stomach Neoplasms
Stomach
Carcinoma
Histology
Fibrosis
Lymph Nodes
Bone Marrow
Drug Therapy

Keywords

  • Cisplatin
  • Gastric cancer
  • Preoperative chemotherapy
  • S-1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Saikawa, Y., Akasaka, Y., Kanai, T., Otani, Y., Kumai, K., Kubota, T., & Kitajima, M. (2003). Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma. Oncology Reports, 10(2), 381-386.

Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma. / Saikawa, Yoshiro; Akasaka, Yoshikiyo; Kanai, Toshio; Otani, Yoshihide; Kumai, Koichiro; Kubota, Tetsuro; Kitajima, Masaki.

In: Oncology Reports, Vol. 10, No. 2, 03.2003, p. 381-386.

Research output: Contribution to journalArticle

Saikawa, Y, Akasaka, Y, Kanai, T, Otani, Y, Kumai, K, Kubota, T & Kitajima, M 2003, 'Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma', Oncology Reports, vol. 10, no. 2, pp. 381-386.
Saikawa Y, Akasaka Y, Kanai T, Otani Y, Kumai K, Kubota T et al. Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma. Oncology Reports. 2003 Mar;10(2):381-386.
Saikawa, Yoshiro ; Akasaka, Yoshikiyo ; Kanai, Toshio ; Otani, Yoshihide ; Kumai, Koichiro ; Kubota, Tetsuro ; Kitajima, Masaki. / Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma. In: Oncology Reports. 2003 ; Vol. 10, No. 2. pp. 381-386.
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