Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

Yoshiro Saikawa, Yoshikiyo Akasaka, Toshio Kanai, Yoshihide Otani, Koichiro Kumai, Tetsuro Kubota, Masaki Kitajima

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19 Citations (Scopus)

Abstract

We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade la effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.

Original languageEnglish
Pages (from-to)381-386
Number of pages6
JournalOncology reports
Volume10
Issue number2
Publication statusPublished - 2003 Mar
Externally publishedYes

Keywords

  • Cisplatin
  • Gastric cancer
  • Preoperative chemotherapy
  • S-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Saikawa, Y., Akasaka, Y., Kanai, T., Otani, Y., Kumai, K., Kubota, T., & Kitajima, M. (2003). Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma. Oncology reports, 10(2), 381-386.