Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

Yoshiro Saikawa; Yoshikiyo Akasaka; Toshio Kanai; Yoshihide Otani; Koichiro Kumai; Tetsuro Kubota; Masaki Kitajima

Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

Yoshiro Saikawa, Yoshikiyo Akasaka, Toshio Kanai, Yoshihide Otani, Koichiro Kumai, Tetsuro Kubota, Masaki Kitajima

Research output: Contribution to journal › Article › peer-review

Abstract

We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade la effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.

Original language	English
Pages (from-to)	381-386
Number of pages	6
Journal	Oncology reports
Volume	10
Issue number	2
Publication status	Published - 2003 Mar
Externally published	Yes

Keywords

Cisplatin
Gastric cancer
Preoperative chemotherapy
S-1

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade la effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.",

keywords = "Cisplatin, Gastric cancer, Preoperative chemotherapy, S-1",

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T1 - Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

AU - Saikawa, Yoshiro

AU - Akasaka, Yoshikiyo

AU - Kanai, Toshio

AU - Otani, Yoshihide

AU - Kumai, Koichiro

AU - Kubota, Tetsuro

AU - Kitajima, Masaki

PY - 2003/3

Y1 - 2003/3

N2 - We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade la effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.

AB - We performed preoperative chemotherapy with S-1 and low-dose CDDP (TSLD) to treat 9 patients of highly advanced gastric cancer. Five cases showed significant effect with severe fibrosis diagnosed as grade 1b-2 effect in histology, and all 9 cases showed at least grade la effect in either primary lesion or lymph node. While toxicity of less than grade 3 (gastrointestinal disorder and/or bone marrow suppression) were observed in 5 out of 9 cases (55.6%), no symptom was observed in 3 out of the 5 patients. We conclude that the TSLD is useful to control highly advanced gastric cancer.

KW - Cisplatin

KW - Gastric cancer

KW - Preoperative chemotherapy

KW - S-1

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Preoperative combination chemotherapy with S-1 and low dose cisplatin against highly advanced gastric carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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