Preoperative radiation therapy for carcinoma of the oropharynx: Prognostic factors for locoregional control and survival

Takashi Uno, Shigeo Yasuda, Koichi Nakano, Takashi Aruga, Koichi Isobe, Hiroyuki Kawakami, Naoyuki Ueno, Tetsuya Kawata, Tsutomu Numata, Hiroshi Nagata, Yoshitaka Okamoto, Hisao Ito

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Abstract

Background: To assess the role of preoperative irradiation and surgery in patients with oropharyneal cancer. Materials and methods: Seventy-five patients were treated with radiotherapy alone or followed by surgery. The stage distribution was stage II in 15 patients, stage III in 16 patients, stage IVA in 38 patients and stage IVB in 6 patients. Results: Thirty-five patients were treated with radiotherapy alone and the remaining 40 underwent definitive surgery after radiation therapy. In the multivariate analysis, both good Kamofsky Performance Status (KPS) and complete response (CR) after radiation therapy had positive impact on locoregional control and survival. Overall survival at 5 years was 65% and 20% for KPS≥90% and KPS<90%, respectively (p<0.0001). Corresponding values for CR and non-CR were 80% and 35%, respectively (p=0.0001). Conclusion: The results indicated that the KPS and complete response after radiation therapy were very sensitive surrogates for locoregional control and survival for cancer of the oropharynx.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalIn Vivo
Volume17
Issue number3
Publication statusPublished - 2003 May

Keywords

  • Complete response
  • Karnofsky Performance Status
  • Neoplasms
  • Oropharynx
  • Preoperative radiation therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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    Uno, T., Yasuda, S., Nakano, K., Aruga, T., Isobe, K., Kawakami, H., Ueno, N., Kawata, T., Numata, T., Nagata, H., Okamoto, Y., & Ito, H. (2003). Preoperative radiation therapy for carcinoma of the oropharynx: Prognostic factors for locoregional control and survival. In Vivo, 17(3), 239-244.