TY - JOUR
T1 - Preparation and evaluation of spherical Ca-deficient hydroxyapatite granules with controlled surface microstructure as drug carriers
AU - Kamitakahara, Masanobu
AU - Imai, Ryohei
AU - Ioku, Koji
N1 - Funding Information:
This research was partially supported by JSPS KAKENHI ( 21300175 ). We are grateful for the experimental help extended by Profs. H. Ishida and K. Tohji of Tohoku University.
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Spherical Ca-deficient hydroxyapatite (HA) granules are expected to be useful drug carriers in bony sites because of their bone regeneration and adsorption ability. In order to control drug loading and release ability of the granules, a controlled surface microstructure was constructed. Spherical Ca-deficient granules composed of micron-sized rod-shaped particles were prepared by hydrothermal treatment of α-tricalcium phosphate (α-TCP) granules, and then, submicron HA particles were precipitated on the obtained granules by immersion in a supersaturated calcium phosphate (CP) solution. When bovine serum albumin was used as a drug model, precipitation of submicron particles causes the loading capability to increase and the release rate to decrease. The spherical Ca-deficient HA granules with the controlled surface microstructure are expected to be useful drug carriers that can act as scaffolds for bone repair.
AB - Spherical Ca-deficient hydroxyapatite (HA) granules are expected to be useful drug carriers in bony sites because of their bone regeneration and adsorption ability. In order to control drug loading and release ability of the granules, a controlled surface microstructure was constructed. Spherical Ca-deficient granules composed of micron-sized rod-shaped particles were prepared by hydrothermal treatment of α-tricalcium phosphate (α-TCP) granules, and then, submicron HA particles were precipitated on the obtained granules by immersion in a supersaturated calcium phosphate (CP) solution. When bovine serum albumin was used as a drug model, precipitation of submicron particles causes the loading capability to increase and the release rate to decrease. The spherical Ca-deficient HA granules with the controlled surface microstructure are expected to be useful drug carriers that can act as scaffolds for bone repair.
KW - Controlled surface microstructure
KW - Drug carrier
KW - Granule
KW - Hydroxyapatite
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U2 - 10.1016/j.msec.2013.01.017
DO - 10.1016/j.msec.2013.01.017
M3 - Article
C2 - 23498281
AN - SCOPUS:84875221454
SN - 0928-4931
VL - 33
SP - 2446
EP - 2450
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
IS - 4
ER -