Preparation and evaluation of spherical Ca-deficient hydroxyapatite granules with controlled surface microstructure as drug carriers

Masanobu Kamitakahara, Ryohei Imai, Koji Ioku

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Spherical Ca-deficient hydroxyapatite (HA) granules are expected to be useful drug carriers in bony sites because of their bone regeneration and adsorption ability. In order to control drug loading and release ability of the granules, a controlled surface microstructure was constructed. Spherical Ca-deficient granules composed of micron-sized rod-shaped particles were prepared by hydrothermal treatment of α-tricalcium phosphate (α-TCP) granules, and then, submicron HA particles were precipitated on the obtained granules by immersion in a supersaturated calcium phosphate (CP) solution. When bovine serum albumin was used as a drug model, precipitation of submicron particles causes the loading capability to increase and the release rate to decrease. The spherical Ca-deficient HA granules with the controlled surface microstructure are expected to be useful drug carriers that can act as scaffolds for bone repair.

Original languageEnglish
Pages (from-to)2446-2450
Number of pages5
JournalMaterials Science and Engineering C
Volume33
Issue number4
DOIs
Publication statusPublished - 2013 May 1

Keywords

  • Controlled surface microstructure
  • Drug carrier
  • Granule
  • Hydroxyapatite

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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