Preparation and functionalization of hollow nanoparticles fabricated by the layer-by-layer deposition

Tomonori Toyoda, Keiji Fujimoto

Research output: Contribution to conferencePaper

Abstract

To prepare hollow particles in a nano size, we used a layer-by-layer deposition. Liposomes were used as a template for this deposition. At first, negatively charged liposomes composed of dilauroyl phosphatidic acid (DLPA) and dimyristoyl phosphatidylcholine (DMPC) were prepared with the extrusion method. Then, polyelectrolytes were adsorbed on the liposomal template. Poly-L-lysine (PLys) and poly-L-aspartic acid (PAsp) were chosen as adsorbates to make a capsule of the biopolymers. When the alternative adsorption of PLys and PAsp on the liposomes was repeated for thickening the capsule layer, their ζ-potentials changed between positive and negative charges at each deposition. To investigate the release behavior from the liposomes and the liposome-polypeptide complexes, we prepared liposomes incorporating 1-hydroxypyrene-3,6,8-trisulfonic acid (HPTS). It was found that the release experiment to the buffered solutions was related to the adsorption of polymers. When the liposomes were completely covered with PLys, the release was suppressed.

Original languageEnglish
Pages5163-5164
Number of pages2
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

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Keywords

  • Biopolymer
  • Hollow particle
  • Layer-by-Layer
  • Nanoparticle

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Toyoda, T., & Fujimoto, K. (2005). Preparation and functionalization of hollow nanoparticles fabricated by the layer-by-layer deposition. 5163-5164. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.