Preparation and properties of phenytoin silica complex nanoparticles

H. Goto, T. Isobe, M. Senna

Research output: Contribution to journalConference article

Abstract

A sparingly soluble model drug, phenytoin (5,5-diphenyl-hydantoin, denoted as PT), was added during hydrolysis and polycondensation of tetra orthoethyl silicate (TEOS). The average size of the composite primary particles after in situ recrystallization of PT and gelation of silica was 2-3 nm. The extent of hydrogen bond (HB) in PT was reduced after the complex formation (CF), while many PT molecules were attached by HB on the surface of silica gel. The apparent solubility to ethanol decreased to 29% to approximately 18% by CF. The first-order rate constant of dissolution of PT into H2O increased by CF up to 40 times. Addition of acrylamide also enhanced the dissolution rate. Mechanisms of faster dissolution were discussed in terms of the hydrogen bond reformation and microstructure.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalMaterials Research Society Symposium - Proceedings
Volume501
Publication statusPublished - 1998 Jan 1
EventProceedings of the 1997 MRS Fall Symposium - Boston, MA, USA
Duration: 1997 Nov 301997 Dec 3

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ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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