Preparation of free-standing hybrid colloidal membranes via assembly of liponanocapsules

Yuuka Fukui, Shuhei Kameyama, Keiji Fujimoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We intended to create a free-standing and organic–inorganic hybrid colloidal membrane. The colloidal membrane was assembled from polymeric capsules, which were prepared by coating of polymer layers over a liposome (liponanocapsules). In this study, two approaches were employed for mineralization over the membrane with calcium phosphate (CaP) to control its mechanical robustness and biodegradability (hybrid bioscaffold). One approach was based on CaP deposition over the liponanocapsules and their assembly into the hybrid membrane. CaP deposition was conducted via the counter-diffusion of phosphate ions and calcium ions across the capsule wall to obtain hybrid nanocapsules. Then, free-standing hybrid membrane was obtained by utilizing hybrid nanocapsules as building blocks for drying-mediated assembly. The obtained hybrid membrane was degraded into individual nanocapsules and degradation could be tuned by the crystal structure of CaP. In another approach, the free-standing membrane was assembled from DNA-coated liponanocapsules and then the counter-diffusion of ions was carried out across each assembled nanocapsule for CaP mineralization. The mechanical robustness of the membrane was significantly improved and its degradation was suppressed by CaP mineralization. This is probably because mineral cross-linkages were formed in the interspace between each nanocapsule. Fluorescent substances could be incorporated in each nanocapsule of the membrane and their release could be tuned by the control in crystal properties of CaP.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalJournal of Biomaterials Science, Polymer Edition
DOIs
Publication statusAccepted/In press - 2017 Feb 25

Fingerprint

Nanocapsules
Calcium phosphate
Membranes
Ions
Capsules
Degradation
calcium phosphate
Liposomes
Biodegradability
Minerals
Calcium
Drying
Polymers
Phosphates
DNA
Crystal structure
Coatings
Crystals

Keywords

  • bioscaffold
  • calcium phosphate
  • Colloidal membrane
  • degradation
  • liponanocapsule
  • liposome
  • mineralization

ASJC Scopus subject areas

  • Bioengineering
  • Biophysics
  • Biomaterials
  • Biomedical Engineering

Cite this

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abstract = "We intended to create a free-standing and organic–inorganic hybrid colloidal membrane. The colloidal membrane was assembled from polymeric capsules, which were prepared by coating of polymer layers over a liposome (liponanocapsules). In this study, two approaches were employed for mineralization over the membrane with calcium phosphate (CaP) to control its mechanical robustness and biodegradability (hybrid bioscaffold). One approach was based on CaP deposition over the liponanocapsules and their assembly into the hybrid membrane. CaP deposition was conducted via the counter-diffusion of phosphate ions and calcium ions across the capsule wall to obtain hybrid nanocapsules. Then, free-standing hybrid membrane was obtained by utilizing hybrid nanocapsules as building blocks for drying-mediated assembly. The obtained hybrid membrane was degraded into individual nanocapsules and degradation could be tuned by the crystal structure of CaP. In another approach, the free-standing membrane was assembled from DNA-coated liponanocapsules and then the counter-diffusion of ions was carried out across each assembled nanocapsule for CaP mineralization. The mechanical robustness of the membrane was significantly improved and its degradation was suppressed by CaP mineralization. This is probably because mineral cross-linkages were formed in the interspace between each nanocapsule. Fluorescent substances could be incorporated in each nanocapsule of the membrane and their release could be tuned by the control in crystal properties of CaP.",
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