Preparation of granules of calcium deficient hydroxyapatite composed of rod-shaped particles and evaluation of their potential for drug carrier

Masanobu Kamitakahara, Kiyoko Sato, Ryosuke Fujii, Ryohei Imai, Koji Ioku

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A combination of a material which is included bone metabolism and a drug to moderate the metabolism is promising for bone regeneration. Spherical granules of rod-shaped hydroxyapatite (HA) were prepared through the hydrothermal process. The size of the granules were about 1 mm in diameter. Their Ca/P molar ratio was 1.61 and this indicates that their composition was not stoichiometric (1.67) but Ca-deficient. Their adsorption ability for tetrahydrocurcumin (THC), which inhibited the proliferation of osteoblast-like cells and show the possibility for pharmacological effect, was revealed. The HA granules with THC has a potential to show the pharmacological effect, accompanied by the resorption of the HA granules according to bone metabolism.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalJournal of the Australian Ceramic Society
Volume47
Issue number1
Publication statusPublished - 2011 Mar 28
Externally publishedYes

Keywords

  • Adsorption
  • Bone
  • Drug carrier
  • Hydrothermal process
  • Hydroxyapatite
  • Tetrahydrocurcumin

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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