Preparation of high-density thermo-responsive polymer grafted surfaces and their application in novel aqueous chromatography column packed materials

Aya Mizutami, Akihiko Kikuchi, Naokazu Idota, Jun Kobayashi, Kiyotaka Sakai, Hideko Kanazawa, Temo Okano

Research output: Contribution to conferencePaper

Abstract

In the present research, thermoresponsive surfaces grafted with high-density poly(N-isopropylacrylamide) (PIPAAm) are prepared by surface-initiated atom transfer radical polymerization (ATRP) on silica-based chromatography column packing materials. Prepared surfaces were analyzed in terms of surface elemental analyses and amount of the grafted polymers increased with increasing reaction time, indicating that reaction proceeds in living fashioa Thermoresponsive surface property alteration was also analyzed in hydrophobic chromatography of hydrophobic bioactive molecules under aqueous mobile phase.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

Keywords

  • Chromatography matrices
  • High-density polymer grafted surfaces
  • Poly(N-isopropylacrylamide)
  • Surface-initiated atom transfer radical polymerization
  • Thermoresponsive polymer

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Mizutami, A., Kikuchi, A., Idota, N., Kobayashi, J., Sakai, K., Kanazawa, H., & Okano, T. (2005). Preparation of high-density thermo-responsive polymer grafted surfaces and their application in novel aqueous chromatography column packed materials. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.