Preparation of methyl ursodeoxycholate in an interface bioreactor: Use of a mixed solvent system to increase the solubilities of substrate and product

Shinobu Oda; Takeshi Sugai; Hiromichi Ohta

doi:10.1263/jbb.92.86

Preparation of methyl ursodeoxycholate in an interface bioreactor: Use of a mixed solvent system to increase the solubilities of substrate and product

Shinobu Oda, Takeshi Sugai, Hiromichi Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A mixed solvent system was used as the reaction solvent of an interface bioreactor for the first time. The solvent, dodecane/2-ethylhexyl acetate (4:6), exhibited excellent efficiency in the preparation of methyl ursodeoxycholate with Eubacterium aerofaciens JCM 7790.

Original language	English
Pages (from-to)	86-88
Number of pages	3
Journal	Journal of Bioscience and Bioengineering
Volume	92
Issue number	1
DOIs	https://doi.org/10.1263/jbb.92.86
Publication status	Published - 2001

Keywords

Anaerobic microorganism
Bile acid ester
Bioconversion
Interface bioreactor
Microbial reduction

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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title = "Preparation of methyl ursodeoxycholate in an interface bioreactor: Use of a mixed solvent system to increase the solubilities of substrate and product",

abstract = "A mixed solvent system was used as the reaction solvent of an interface bioreactor for the first time. The solvent, dodecane/2-ethylhexyl acetate (4:6), exhibited excellent efficiency in the preparation of methyl ursodeoxycholate with Eubacterium aerofaciens JCM 7790.",

keywords = "Anaerobic microorganism, Bile acid ester, Bioconversion, Interface bioreactor, Microbial reduction",

author = "Shinobu Oda and Takeshi Sugai and Hiromichi Ohta",

note = "Funding Information: We expresso ur sinceret hankst o Mrs. Midori Nagase,T echnical ResearchL aboratoryK, ansai Paint Co., Ltd., for her technicala ssis-tance.T his work was supportedin part by the Japan Key Technology Center,T okyo. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2001",

doi = "10.1263/jbb.92.86",

language = "English",

volume = "92",

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journal = "Journal of Bioscience and Bioengineering",

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AU - Oda, Shinobu

AU - Sugai, Takeshi

AU - Ohta, Hiromichi

N1 - Funding Information: We expresso ur sinceret hankst o Mrs. Midori Nagase,T echnical ResearchL aboratoryK, ansai Paint Co., Ltd., for her technicala ssis-tance.T his work was supportedin part by the Japan Key Technology Center,T okyo. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2001

Y1 - 2001

N2 - A mixed solvent system was used as the reaction solvent of an interface bioreactor for the first time. The solvent, dodecane/2-ethylhexyl acetate (4:6), exhibited excellent efficiency in the preparation of methyl ursodeoxycholate with Eubacterium aerofaciens JCM 7790.

AB - A mixed solvent system was used as the reaction solvent of an interface bioreactor for the first time. The solvent, dodecane/2-ethylhexyl acetate (4:6), exhibited excellent efficiency in the preparation of methyl ursodeoxycholate with Eubacterium aerofaciens JCM 7790.

KW - Anaerobic microorganism

KW - Bile acid ester

KW - Bioconversion

KW - Interface bioreactor

KW - Microbial reduction

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Preparation of methyl ursodeoxycholate in an interface bioreactor: Use of a mixed solvent system to increase the solubilities of substrate and product

Abstract

Keywords

ASJC Scopus subject areas

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