Preparation of methyl ursodeoxycholate in an interface bioreactor: Use of a mixed solvent system to increase the solubilities of substrate and product

Shinobu Oda, Takeshi Sugai, Hiromichi Ohta

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2 Citations (Scopus)


A mixed solvent system was used as the reaction solvent of an interface bioreactor for the first time. The solvent, dodecane/2-ethylhexyl acetate (4:6), exhibited excellent efficiency in the preparation of methyl ursodeoxycholate with Eubacterium aerofaciens JCM 7790.

Original languageEnglish
Pages (from-to)86-88
Number of pages3
JournalJournal of Bioscience and Bioengineering
Issue number1
Publication statusPublished - 2001 Jan 1



  • Anaerobic microorganism
  • Bile acid ester
  • Bioconversion
  • Interface bioreactor
  • Microbial reduction

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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