Preparation of Monomethyl Ether Derivatives of (+)-,(—)- and (±)-Indenestrols A and B

Taiko Oda; Yoshihiro Sato

doi:10.1248/cpb.41.1856

Preparation of Monomethyl Ether Derivatives of (+)-,(—)- and (±)-Indenestrols A and B

Taiko Oda, Yoshihiro Sato

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

In order to evaluate the contribution of the two phenolic hydroxyl groups to the biological activities of indenestrols A (IA) and B (IB), monomethyl ether derivatives of IA and IB were prepared and each enantiomer was separated to > 99% purity by high-pressure liquid chromatography using a chiral column. The structures of the enantiomers were confirmed by proton and carbon-13 nuclear magnetic resonance and circular dichroism spectroscopic studies.

Original language	English
Pages (from-to)	1856-1859
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	41
Issue number	10
DOIs	https://doi.org/10.1248/cpb.41.1856
Publication status	Published - 1993 Jan 1

Keywords

circular dichroism
indenestrol A monomethyl ether
indenestrol B monomethyl ether
optical resolution

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.41.1856

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author = "Taiko Oda and Yoshihiro Sato",

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AU - Oda, Taiko

AU - Sato, Yoshihiro

PY - 1993/1/1

Y1 - 1993/1/1

N2 - In order to evaluate the contribution of the two phenolic hydroxyl groups to the biological activities of indenestrols A (IA) and B (IB), monomethyl ether derivatives of IA and IB were prepared and each enantiomer was separated to > 99% purity by high-pressure liquid chromatography using a chiral column. The structures of the enantiomers were confirmed by proton and carbon-13 nuclear magnetic resonance and circular dichroism spectroscopic studies.

AB - In order to evaluate the contribution of the two phenolic hydroxyl groups to the biological activities of indenestrols A (IA) and B (IB), monomethyl ether derivatives of IA and IB were prepared and each enantiomer was separated to > 99% purity by high-pressure liquid chromatography using a chiral column. The structures of the enantiomers were confirmed by proton and carbon-13 nuclear magnetic resonance and circular dichroism spectroscopic studies.

KW - circular dichroism

KW - indenestrol A monomethyl ether

KW - indenestrol B monomethyl ether

KW - optical resolution

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JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 10

ER -

Preparation of Monomethyl Ether Derivatives of (+)-,(—)- and (±)-Indenestrols A and B

Abstract

Keywords

ASJC Scopus subject areas

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