In order to evaluate the contribution of the two phenolic hydroxyl groups to the biological activities of indenestrols A (IA) and B (IB), monomethyl ether derivatives of IA and IB were prepared and each enantiomer was separated to > 99% purity by high-pressure liquid chromatography using a chiral column. The structures of the enantiomers were confirmed by proton and carbon-13 nuclear magnetic resonance and circular dichroism spectroscopic studies.
- circular dichroism
- indenestrol A monomethyl ether
- indenestrol B monomethyl ether
- optical resolution
ASJC Scopus subject areas
- Drug Discovery