Preparation of monomethyl ether derivatives of (+)-, (-)- and (±)- indenestrols A and B

T. Oda, Y. Sato

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In order to evaluate the contribution of the two phenolic hydroxyl groups to the biological activities of indenestrols A (IA) and B (IB), monomethyl ether derivatives of IA and IB were prepared and each enantiomer was separated to > 99% purity by high-pressure liquid chromatography using a chiral column. The structures of the enantiomers were confirmed by proton and carbon-13 nuclear magnetic resonance and circular dichroism spectroscopic studies.

Original languageEnglish
Pages (from-to)1856-1859
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume41
Issue number10
Publication statusPublished - 1993

Fingerprint

Enantiomers
Ether
High pressure liquid chromatography
Derivatives
Circular Dichroism
Bioactivity
Hydroxyl Radical
Protons
Magnetic Resonance Spectroscopy
Carbon
High Pressure Liquid Chromatography
Nuclear magnetic resonance
indenestrol B
indenestrol

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Preparation of monomethyl ether derivatives of (+)-, (-)- and (±)- indenestrols A and B. / Oda, T.; Sato, Y.

In: Chemical and Pharmaceutical Bulletin, Vol. 41, No. 10, 1993, p. 1856-1859.

Research output: Contribution to journalArticle

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