Preparation of novel chromatography matrices having thermoresponisve polymer brush structure

Kenichi Nagase, Aya Mizutani, Jun Kobayashi, Akihiko Kikuchi, Yoshikatsu Akiyama, Hideko Kanazawa, Teruo Okano

Research output: Contribution to conferencePaper

Abstract

We prepared Chromatography matrices having thermoresponisve polymer brush structure by atom transfer radical polymerization (ATRP) of N- isopropylacrylamide (IPAAm) on silica beads. Retention times for steroids extended with increasing grafted PIPAAm amounts controlled by polymerizatuion times. Elution profiles of steroids on column packed with PIPAAm-grafted matrices prepared by ATRP depend largely on the column temperature. This indicates that matrices having thermoresponisve polymer brush layers would be useful for controlling strong hydrophobicity of HPLC stationary phases simply by changing column temperature.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • Green chemistry
  • Hydrophobic Chromatography
  • Living radical polymerization
  • Polymer brush
  • Thermoresponsive surfaces

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Nagase, K., Mizutani, A., Kobayashi, J., Kikuchi, A., Akiyama, Y., Kanazawa, H., & Okano, T. (2005). Preparation of novel chromatography matrices having thermoresponisve polymer brush structure. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.