Preparation of spherical porous granules composed of rod-shaped hydroxyapatite and evaluation of their protein adsorption properties

Toshiharu Takahashai; Masanobu Kamitakahara; Giichiro Kawachi; Koji Ioku

Preparation of spherical porous granules composed of rod-shaped hydroxyapatite and evaluation of their protein adsorption properties

Toshiharu Takahashai, Masanobu Kamitakahara, Giichiro Kawachi, Koji Ioku

Research output: Contribution to journal › Article › peer-review

Abstract

The present study examined the possibility of using spherical porous granules of hydroxyapatite (HA, Ca₁₀(PO₄) ₆(OH)₂) composed of rod-shaped particles as the drug delivery system. The granules composed of rod-shaped HA were successfully prepared by an emulsion method and a hydrothermal treatment When the rod-shaped granules were soaked in phosphate buffer salines containing lysozyme chloride or albumin, the granules of rod-shaped HA adsorbed more albumin than lysozyme. On the other hand, the HA granules prepared by a normal sintering method adsorbed little lysozyme chloride or albumin. The HA granules composed of rod-shaped particles are expected to be useful as carriers of negatively charged substances.

Original language	English
Pages (from-to)	83-86
Number of pages	4
Journal	Key Engineering Materials
Volume	361-363 I
Publication status	Published - 2008 Jan 1
Externally published	Yes

Keywords

Adsorption properties
Granules
Hydroxyapatite

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

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abstract = "The present study examined the possibility of using spherical porous granules of hydroxyapatite (HA, Ca10(PO4) 6(OH)2) composed of rod-shaped particles as the drug delivery system. The granules composed of rod-shaped HA were successfully prepared by an emulsion method and a hydrothermal treatment When the rod-shaped granules were soaked in phosphate buffer salines containing lysozyme chloride or albumin, the granules of rod-shaped HA adsorbed more albumin than lysozyme. On the other hand, the HA granules prepared by a normal sintering method adsorbed little lysozyme chloride or albumin. The HA granules composed of rod-shaped particles are expected to be useful as carriers of negatively charged substances.",

keywords = "Adsorption properties, Granules, Hydroxyapatite",

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T1 - Preparation of spherical porous granules composed of rod-shaped hydroxyapatite and evaluation of their protein adsorption properties

AU - Takahashai, Toshiharu

AU - Kamitakahara, Masanobu

AU - Kawachi, Giichiro

AU - Ioku, Koji

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The present study examined the possibility of using spherical porous granules of hydroxyapatite (HA, Ca10(PO4) 6(OH)2) composed of rod-shaped particles as the drug delivery system. The granules composed of rod-shaped HA were successfully prepared by an emulsion method and a hydrothermal treatment When the rod-shaped granules were soaked in phosphate buffer salines containing lysozyme chloride or albumin, the granules of rod-shaped HA adsorbed more albumin than lysozyme. On the other hand, the HA granules prepared by a normal sintering method adsorbed little lysozyme chloride or albumin. The HA granules composed of rod-shaped particles are expected to be useful as carriers of negatively charged substances.

AB - The present study examined the possibility of using spherical porous granules of hydroxyapatite (HA, Ca10(PO4) 6(OH)2) composed of rod-shaped particles as the drug delivery system. The granules composed of rod-shaped HA were successfully prepared by an emulsion method and a hydrothermal treatment When the rod-shaped granules were soaked in phosphate buffer salines containing lysozyme chloride or albumin, the granules of rod-shaped HA adsorbed more albumin than lysozyme. On the other hand, the HA granules prepared by a normal sintering method adsorbed little lysozyme chloride or albumin. The HA granules composed of rod-shaped particles are expected to be useful as carriers of negatively charged substances.

KW - Adsorption properties

KW - Granules

KW - Hydroxyapatite

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VL - 361-363 I

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Preparation of spherical porous granules composed of rod-shaped hydroxyapatite and evaluation of their protein adsorption properties

Abstract

Keywords

ASJC Scopus subject areas

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